Photobiomodulation: lasers vs. light emitting diodes?

Photochemical & Photobiological Sciences, Journal Year: 2018, Volume and Issue: 17(8), P. 1003 - 1017

Published: July 13, 2018

Language: Английский

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Non-invasive, opsin-free mid-infrared modulation activates cortical neurons and accelerates associative learning

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 12, 2021

Abstract Neurostimulant drugs or magnetic/electrical stimulation techniques can overcome attention deficits, but these are weakly beneficial in boosting the learning capabilities of healthy subjects. Here, we report a technique, mid-infrared modulation (MIM), that delivers light energy through opened skull even non-invasively thinned intact and activate brain neurons vivo without introducing any exogeneous gene. Using c-Fos immunohistochemistry, single-cell electrophysiology two-photon Ca 2+ imaging mice, demonstrate MIM significantly induces firing activities targeted cortical area. Moreover, mice receive targeting to auditory cortex during an associative task exhibit faster speed (~50% faster) than control mice. Together, this non-invasive, opsin-free technique is demonstrated with potential for modulating neuronal activity.

Language: Английский

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Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 8

Published: Jan. 5, 2021

The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial dysfunction has an established and prominent role. This supported by already large rapidly growing body evidence showing that the role (dys)function central multifaceted. However, there are clear gaps in knowledge, including dilemma explaining why inherited mitochondriopathies do not usually present with parkinsonian symptoms. Many aspects function potential therapeutic targets, reactive oxygen species production, mitophagy, biogenesis, dynamics trafficking, metal ion homeostasis, sirtuins, endoplasmic reticulum links mitochondria. Potential strategies may also incorporate exercise, microRNAs, transplantation, stem cell therapies, photobiomodulation. Despite multiple studies adopting numerous treatment strategies, clinical trials to date have generally failed show benefit. To overcome this hurdle, more accurate biomarkers required detect subtle beneficial effects. Furthermore, selecting study participants early course, studying them for suitable durations, stratifying according genetic neuroimaging findings increase likelihood successful trials. Moreover, treatments involving combined approaches will likely better address complexity disease. Therefore, right patients, at time, using targeted combination treatments, offer best chance development effective novel therapy targeting

Language: Английский

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Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

Theranostics, Journal Year: 2022, Volume and Issue: 12(5), P. 2205 - 2231

Published: Jan. 1, 2022

Alzheimer's disease (AD) is the most common form of dementia in elderly, causing neuronal degeneration and cognitive deficits that significantly impair independence quality life for those affected their families.Though AD a major neurodegenerative with vast avenues investigation, there no effective treatment to cure or slow progression.The present work evaluated therapeutic effect long-term photobiomodulation (PBM) continuous-wave low-level laser on its underlying mechanism.Methods: PBM was implemented 2 min, 3 times per week 16 months 2-month-old transgenic rats.A battery behavioral tests performed measure dysfunction rats.The effects therapy typical pathologies, including amyloid plaques, intracellular neurofibrillary tangles, loss, injury, apoptosis, neurodegeneration, were then assessed.The mechanisms measured using immunofluorescence staining, western blotting analysis, mass spectrometry, primary cortical hippocampal cell cultures, related assay kits.Results: improved pathologies memory tau hyperphosphorylation, degeneration, spine damage, synaptic loss.PBM had several mechanistic which may explain these beneficial effects, 1) regulation glial polarization inhibition neuroinflammation, 2) preservation mitochondrial dynamics by regulating fission fusion proteins, 3) suppression oxidative damage DNA, lipids.Furthermore, enhanced recruitment microglia surrounding plaques improving expression microglial IL-3Rα astrocytic IL-3, implies potential role Aβ clearance.Finally, our results implicate hemoglobin mediating neuroprotective PBM, as Hbα knockdown abolished treatment.Conclusion: Collectively, data supports use prevent progression provides new insights into molecular therapy.

Language: Английский

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Mitochondrial dysfunction and neurological disorders: A narrative review and treatment overview

Life Sciences, Journal Year: 2023, Volume and Issue: 334, P. 122257 - 122257

Published: Nov. 8, 2023

Language: Английский

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Wearable and Implantable Light-Emitting Diodes and Their Biomedical Applications

Korean Journal of Chemical Engineering, Journal Year: 2024, Volume and Issue: 41(1), P. 1 - 24

Published: Jan. 1, 2024

Language: Английский

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Correction: Photobiomodulation: lasers vs. light emitting diodes?

Photochemical & Photobiological Sciences, Journal Year: 2018, Volume and Issue: 18(1), P. 259 - 259

Published: Oct. 31, 2018

Correction for 'Photobiomodulation: lasers vs. light emitting diodes?' by Vladimir Heiskanen and Michael R. Hamblin, Photochem. Photobiol. Sci., 2018, 17, 1003-1017.

Language: Английский

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Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillations: a pilot exploratory study

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: April 19, 2019

Transcranial photobiomodulation (tPBM) is the application of low levels red or near-infrared (NIR) light to stimulate neural tissues. Here, we administer tPBM in form NIR (810 nm wavelength) pulsed at 40 Hz default mode network (DMN), and examine its effects on human oscillations, a randomized, sham-controlled, double-blinded trial. Using electroencephalography (EEG), found that single session significantly increases power higher oscillatory frequencies alpha, beta gamma reduces slower delta theta subjects resting state. Furthermore, analysis properties using inter-regional synchrony via weighted phase lag index (wPLI) graph theory measures, indicate effect integration segregation brain networks. These changes were different when compared sham stimulation. Our preliminary findings demonstrate for first time can be used non-invasively modulate encourage further confirmatory clinical investigations.

Language: Английский

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Penetration Profiles of Visible and Near-Infrared Lasers and Light-Emitting Diode Light Through the Head Tissues in Animal and Human Species: A Review of Literature

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2019, Volume and Issue: 37(10), P. 581 - 595

Published: Sept. 25, 2019

Background and objective: Photobiomodulation (PBM) therapy is a promising noninvasive approach to stimulate neuronal function improve brain repair. The optimization of PBM parameters important maximize effectiveness tolerability. Several studies have reported on the penetration visible-to-near-infrared (NIR) light through various animal human tissues. Scientific findings vary, likely due use different irradiation characteristics subject such as species, age, gender. Materials methods: In this article, we review published data tissues head in both species. patterns visible-to-NIR are summarized based following study specifications: wavelength, coherence, operation mode, beam type size, site, Results: average transcranial red/NIR (630–810 nm) ranged 60–70% C57BL/6 mouse (skull), 1–10% BALB/c 10–40% Sprague–Dawley rats (scalp plus skull), 20% Oryctolagus cuniculus rabbit 0.11% pig 0.2–10% humans skull). observed variation values difference factors (e.g., wavelengths, tissue thickness, anatomic site) used by researchers. It seems that these challenge applicability model humans. Nevertheless, two models seem particularly promising, they approximate humans: (I) Penetration 808 nm laser scalp skull was head; (II) 810 intact 1.75% mouse. Conclusions: conclusion, it worthwhile mentioning since closely dependent amount energy reaching target neurons, further quantitative estimation depth should be performed validate current findings.

Language: Английский

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Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Brain Research Bulletin, Journal Year: 2018, Volume and Issue: 144, P. 213 - 222

Published: Oct. 29, 2018

Language: Английский

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