Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2611 - 2611
Published: Nov. 15, 2024
Telomere
length
function
serves
as
a
critical
biomarker
for
biological
aging
and
overall
health.
Its
maintenance
is
linked
to
cancer,
neurodegenerative
conditions,
reproductive
This
review
mainly
examines
genetic
variations
environmental
influences
on
telomere
dynamics,
highlighting
key
regulatory
genes
mechanisms.
Advances
in
measurement
methodologies
are
also
reviewed,
underscoring
the
importance
of
precise
assessment
disease
prevention
treatment.
Telomerase
activation
offers
potential
cellular
lifespan
extension
anti-aging
effects,
whereas
its
inhibition
emerges
promising
therapeutic
approach
cancer.
Regulatory
mechanisms
tumor
suppressor
telomerase
activity
analyzed,
with
comprehensive
overview
current
state
future
inhibitors.
In
addition,
association
between
telomeres
diseases
discussed,
detailing
how
attrition
heightens
risk
outlining
multiple
pathways
by
which
protects
neurons
from
damage
apoptosis.
Human Genomics,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: June 3, 2024
Several
lines
of
evidence
suggest
that
leukocyte
telomere
length
(LTL)
can
affect
the
development
prostate
cancer
(PC).
Here,
we
employed
single
nucleoside
polymorphisms
(SNPs)
as
instrumental
variables
(IVs)
for
LTL
(n
=
472,174)
and
conducted
Mendelian
randomization
analysis
to
estimate
their
causal
impact
on
PCs
(79,148
patients/61,106
controls
6311
patients/88,902
controls).
Every
1-s.d
extension
increased
risk
by
34%.
Additionally,
candidate
mediators
between
via
two-step
revealed
among
23
candidates,
Alzheimer's
disease,
liver
iron
content,
sex
hormone
binding
global
levels,
naive
CD4-CD8-T
cell%
T
cell,
circulating
leptin
levels
played
substantial
mediating
roles.
There
is
no
robust
support
reverse
relationship
selected
PCs.
Adjusting
former
four
mediators,
rather
than
adjusting
decreased
This
study
provides
potential
intervention
measures
preventing
LTL-induced
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 11859 - 11859
Published: Nov. 5, 2024
High
blood
pressure
(BP)
is
a
significant
contributor
to
the
disease
burden
globally
and
emerging
as
an
important
cause
of
morbidity
mortality
in
young
well
old.
The
well-established
impact
high
BP
on
neurodegeneration,
cognitive
impairment,
dementia
widely
acknowledged.
However,
influence
across
its
full
range
remains
unclear.
This
review
aims
explore
more
detail
effects
levels
function,
dementia.
Moreover,
given
pressing
need
identify
strategies
reduce
levels,
particular
attention
placed
reviewing
role
magnesium
(Mg)
ageing
capacity
lower
therefore
potentially
promote
brain
health.
Overall,
provide
comprehensive
synthesis
evidence
linking
BP,
Mg
It
hoped
that
these
insights
will
inform
development
cost-effective
scalable
interventions
protect
health
population.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2611 - 2611
Published: Nov. 15, 2024
Telomere
length
function
serves
as
a
critical
biomarker
for
biological
aging
and
overall
health.
Its
maintenance
is
linked
to
cancer,
neurodegenerative
conditions,
reproductive
This
review
mainly
examines
genetic
variations
environmental
influences
on
telomere
dynamics,
highlighting
key
regulatory
genes
mechanisms.
Advances
in
measurement
methodologies
are
also
reviewed,
underscoring
the
importance
of
precise
assessment
disease
prevention
treatment.
Telomerase
activation
offers
potential
cellular
lifespan
extension
anti-aging
effects,
whereas
its
inhibition
emerges
promising
therapeutic
approach
cancer.
Regulatory
mechanisms
tumor
suppressor
telomerase
activity
analyzed,
with
comprehensive
overview
current
state
future
inhibitors.
In
addition,
association
between
telomeres
diseases
discussed,
detailing
how
attrition
heightens
risk
outlining
multiple
pathways
by
which
protects
neurons
from
damage
apoptosis.
