Review on pathogenesis and treatment of Alzheimer's disease DOI Open Access

Jinxia Cai,

Yanqing Liu,

Haojun Fan

et al.

Developmental Dynamics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

The rising incidence of Alzheimer's disease (AD) and the associated economic impacts has prompted a global focus in field. In recent years, there been growing understanding pathogenic mechanisms AD, including aggregation β-amyloid, hyperphosphorylated tau, neuroinflammation. These processes collectively lead to neurodegeneration cognitive decline, which ultimately results loss autonomy patients. Currently, are three main types AD treatments: clinical tools, pharmacological treatment, material interventions. This review provides comprehensive analysis underlying etiology pathogenesis as well an overview current prevalence treatments. We believe this article can help deepen our mechanism, facilitate translation scientific research or therapies, address problem AD.

Language: Английский

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases DOI Creative Commons
Yumin Wang, Jing Hu, Shuang Wu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 10, 2023

Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt

Language: Английский

Citations

72
The Link Between Matrix Metalloproteinases and Alzheimer’s Disease Pathophysiology DOI Creative Commons

Dominika Radošinská,

Jana Radošinská

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Alzheimer's disease (AD) is a major contributor to dementia and the most common neurodegenerative disorder. In AD pathophysiology, matrix metalloproteinases (MMPs)-proteolytic enzymes, best known be responsible for remodeling degradation of extracellular matrix-were suggested play an important role. Due diverse nature published data frequent inconsistent results presented in available papers, it was considered essential analyze all aspects MMP literature with respect pathophysiology attempt outline unifying concept understanding their role AD. Thus, main contribution this review article summarize recent research on participation obtained using cell cultures understand molecular principles action. Furthermore, updated comprehensive view regarding topic based exclusively papers from human studies provided as well. It can concluded that determining exact any particular MMPs holds promise establishing potential biomarkers reflecting severity or progression developing new therapeutic agents targeting processes lead

Language: Английский

Citations

10
Navigating the Maze of Alzheimer’s disease by exploring BACE1: Discovery, current scenario, and future prospects DOI

Faiza Iram,

Mohammad Shahid, Jaoud Ansari

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102342 - 102342

Published: May 16, 2024

Language: Английский

Citations

7
A bibliometric and visual analysis of epigenetic research publications for Alzheimer’s disease (2013–2023) DOI Creative Commons

Zhao YaPing,

WenJing Ai,

JingFeng Zheng

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Jan. 16, 2024

Background Currently, the prevalence of Alzheimer’s disease (AD) is progressively rising, particularly in developed nations. There an escalating focus on onset and progression AD. A mounting body research indicates that epigenetics significantly contributes to AD holds substantial promise as a novel therapeutic target for its treatment. Objective The objective this article present areas interest, comprehend contextual framework subject research, investigate prospective direction future development. Methods ln Web Science Core Collection (WOSCC), we searched documents by specific terms their corresponding free words. VOSviewer, CiteSpace Scimago Graphica were used perform statistical analysis measurement metrics such number published papers, national cooperative networks, publishing countries, institutions, authors, co-cited journals, keywords, visualize networks related content elements. Results We selected 1,530 articles from WOSCC January 2013 June 2023 about Based visual analysis, could get China United States countries with most field. Bennett DA was contributed prestigious scientist. top 3 cited journals Journal Disease, Neurobiology Aging Molecular Neurobiology. According keywords frequency citations, ncRNAs, transcription factor, genome, histone modification, blood DNA methylation, acetylation, biomarkers hot directions today. Conclusion bibliometric epigenetic promising direction, had potential be targets.

Language: Английский

Citations

5
A comprehensive study on epigenetic biomarkers in early detection and prognosis of Alzheimer's disease DOI Creative Commons
Dhruv Parikh, Manan Shah

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(2), P. 138 - 153

Published: June 1, 2024

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques and tau tangles, disrupting brain cell communication, causing atrophy, leading to cognitive decline. It poses substantial global health challenge, necessitating urgent research. Molecular biomarkers, reflecting AD progression, have been identified in diverse bodily tissues. Notably, emerging epigenetic biomarkers introduce novel dimension pathophysiology. However, their precise role early detection prognosis remains unclear. This review classifies various emphasizing potential prognosis. Various like DNA methylation, non-coding RNAs, histone modification, OMICS, many more get significantly altered during AD; these being distinctly expressed normal conditions offer huge therapeutic benefit stop the progression or worsening it. We explore implications propose integration with existing diagnostic methods intervene mitigating exacerbation. Addressing challenges, we envision future scope of synergy computational approaches for enhanced detection. contributes field proposing multifaceted approach that combines markers analysis improve facilitate timely interventions. Furthermore, discuss economic application could reduce financial burden delaying severity disease.

Language: Английский

Citations

5
Gene Co-Expression Analysis Reveals Functional Differences Between Early- and Late-Onset Alzheimer’s Disease DOI Creative Commons

Abel Isaías Gutiérrez Cruz,

Guillermo de Anda‐Jáuregui, Enrique Hernández-Lemus

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 200 - 200

Published: March 18, 2025

The rising prevalence of Alzheimer’s disease (AD), particularly among older adults, has driven increased research into its underlying mechanisms and risk factors. Aging, genetic susceptibility, cardiovascular health are recognized contributors to AD, but how the age onset affects progression remains underexplored. This study investigates role early- versus late-onset (EOAD LOAD, respectively) in shaping trajectory cognitive decline. Leveraging data from Religious Orders Study Memory Aging Project (ROSMAP), two cohorts were established: individuals with early-onset AD those AD. Comprehensive analyses, including differential gene expression profiling, pathway enrichment, co-expression network construction, conducted identify distinct molecular signatures associated each cohort. Network modularity learning algorithms used discern inner structure networks their related functional features. Computed descriptors provided deeper insights influence at on biological

Language: Английский

Citations

0
In silico detection of dysregulated genes and molecular pathways in Alzheimer’s disease as basis for food restoring approach DOI Creative Commons

Ilaria Petrignani,

Alessandra Pasquo, Roberto Bei

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19100 - e19100

Published: April 7, 2025

Forty-eight million people worldwide suffer from dementia, often associated with the growth of elderly population. There are also concerns about younger population, where increasing acute and chronic abuse alcohol neurotoxic substances may contribute to brain damage early onset dementia. Alzheimer’s disease (AD) accounts for 60% dementia cases most therapies used so far have been unsuccessful. Genetic, epigenetic vascular factors pathogenesis AD. Among mechanisms, modulation microRNA (miRs) plays an important role. To detect genes pathways involved in AD, we performed original bioinformatic analysis published dysregulated miRs using MIcroRNA ENrichment TURned NETwork (MIENTURNET) followed by Reactome tools. The interrogation these platforms allowed us discover common putative (by MIENTURNET) targeted which set altered tool). Our silico showed that β-catenin phosphorylation cascade Netrin-1 signalling, resulted as significant. Lastly, based on assumption food bioactive compounds (BC) modulate miRs, turn a literature search demonstrated some BC indeed able genes. Curcumin, osthole, puerarin, xanthoceraside, sulforaphane, salvianolic acid A, resveratrol andrographolide lead upregulation Wnt/β-catenin pathway. Choline, methionine, folate vitamin B6/B12 In conclusion, our identified their pathways, paving interesting new insights diagnosis potential therapeutic interventions.

Language: Английский

Citations

0
Cadmium‐induced global DNA hypermethylation promoting mitochondrial dynamics dysregulation in hippocampal neurons DOI
Huixia Geng,

Qihang An,

Jie Song

et al.

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 39(4), P. 2043 - 2051

Published: Dec. 14, 2023

Abstract Environmental cadmium exposure during pregnancy or adolescence can cause neurodevelopmental toxicity, lead to neurological impairment, and reduce cognitive abilities, such as learning memory. However, the mechanisms by which causes toxicity impairment are still not fully elucidated. This study used hippocampal neurons cultured in vitro observe impact of on mitochondrial dynamics apoptosis. Exposure 5 μM degradation neuron cell bodies axons, morphological destruction, low viability, apoptosis increase. Cadmium upregulates expression fission proteins Drp1 Fis1, reduces fusion‐related MFN1, MFN2, OPA1, well PGC‐1a. Mitochondrial morphology detection demonstrated that changes structure mitochondria neurons, increasing number punctate granular mitochondria, reducing tubular reticular decreasing mass, dissipating membrane potential (ΔΨm), adenosine triphosphate (ATP) production. increases global methylation level genome DNMT1 DNMT3α neurons. 5‐Aza‐CdR cadmium‐induced levels promotes viability. In conclusion, regulates dynamics‐related methylation, changing function, exerting neurotoxic effects.

Language: Английский

Citations

4
Review article: the role of epigenetics as an underlying regulator of the immune responses in Parkinson’s disease DOI Creative Commons

Maria Georgoula,

Panagiotis Ntavaroukas,

Barry J. Campbell

et al.

Epigenetics Reports, Journal Year: 2024, Volume and Issue: 2(1), P. 1 - 14

Published: Sept. 10, 2024

Language: Английский

Citations

0
Two Sides of the Same Coin: Genes Involved in Neurodegeneration and Cancer DOI
Martina Montanari, Maria Meringolo, Ilham El Atiallah

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The relationship between cancer and neurodegeneration has spurred extensive scientific discourse, challenging their historical classification as distinct disorders. While signifies uncontrolled cellular proliferation marks progressive neuronal loss, recent insights highlight intriguing interconnections these seemingly disparate conditions. Cancer entails perpetual signaling for growth, evasion of growth inhibitors, resistance to cell death, acquisition replicative immortality, stimulation blood vessel (angiogenesis), initiation invasion metastasis. Conversely, investigations emphasize disrupted energy regulation immune surveillance key traits arising from genome instability, mutations, inflammation driving tumorigenesis. Neurodegeneration involves malfunction depletion, synaptic impairment, protein abnormality aggregations contributing muscle atrophy cognitive deficits. Varied clinical studies underscore contrasting correlations neurodegeneration, hinting at mirrored molecular pathways that foster resilience or vulnerability. Research explores in tumorigenesis, shared with neurodegenerative Aberrant expression mutations crucial genes implicated also surface contexts. Debates persist on the nature contemplating inverse associations pathways. Understanding complex interplay, encompassing genetics, mechanisms, environmental influences, remains pivotal unraveling connections. This review perspective might share fundamental genetic links, delving into potential implications onset progression.

Language: Английский

Citations

0