Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Sept. 10, 2024
The
exploration
of
targeted
therapy
has
proven
to
be
a
highly
promising
avenue
in
the
realm
drug
development
research.
human
body
generates
substantial
amount
free
radicals
during
metabolic
processes,
and
if
not
promptly
eliminated,
these
can
lead
oxidative
stress,
disrupting
homeostasis
potentially
contributing
chronic
diseases
cancers.
Before
contemporary
medicine
with
synthetic
pharmaceuticals
antioxidants,
there
was
long-standing
practice
employing
raw,
natural
ingredients
cure
variety
illnesses.
This
persisted
even
after
active
antioxidant
molecules
were
known.
ability
antioxidants
neutralise
excess
so
prevent
wide
range
term
"natural
antioxidant"
refers
compounds
derived
from
plants
or
other
living
organisms
that
have
control
production
radicals,
scavenge
them,
stop
radical-mediated
chain
reactions,
lipid
peroxidation.
These
strong
potential
inhibit
stress.
Phytochemicals
(antioxidants)
plants,
such
as
polyphenols,
carotenoids,
vitamins,
others,
are
central
discussion
antioxidants.
Not
only
may
chemicals
increase
endogenous
defenses,
affect
communication
cascades,
gene
expression,
but
they
also
shown
radical
scavenging
properties.
study
comprehensively
summarizes
primary
classes
found
different
plant
animal
source
contribute
prevention
treatment
diseases.
Additionally,
it
outlines
research
progress
future
prospects.
discoveries
establish
theoretical
groundwork
for
pharmacological
present
inventive
ideas
addressing
challenges
medical
treatment.
Molecules,
Journal Year:
2024,
Volume and Issue:
30(1), P. 20 - 20
Published: Dec. 25, 2024
Diabetic
nephropathy
(DN)
is
a
common
and
serious
complication
of
diabetes
mellitus
major
cause
end-stage
renal
disease
(ESRD).
Renal
fibrosis,
which
corresponds
to
excessive
deposition
extracellular
matrix
leads
scarring,
characteristic
feature
the
various
progressive
stages
DN.
It
can
trigger
pathological
processes
leading
activation
autophagy,
inflammatory
responses
vicious
circle
oxidative
stress
inflammation.
Although
it
known
that
DN
be
alleviated
by
mechanisms
linked
antioxidants,
reducing
inflammation
improving
how
improve
fibrosis
using
natural
polyphenols
needs
studied
further.
Nowadays,
polyphenolic
compounds
with
excellent
safety
efficacy
are
playing
an
increasingly
important
role
in
drug
discovery.
Therefore,
this
review
reveals
multiple
associated
DN,
as
well
different
signaling
pathways
(including
TGF-β/SMAD,
mTORC1/p70S6K,
JAK/STAT/SOCS
Wnt/β-catenin)
potential
fibrotic
niche.
In
parallel,
we
summarize
types
their
pharmacodynamic
effects,
finally
evaluate
use
modulate
relevant
targets
pathways,
providing
research
directions
for
summary,
problem
long-term
monotherapy
resistance
reduced
polyphenols,
while
incidence
toxic
side
effects.
addition,
inhibitors
identified
through
these
offering
avenues
pharmacological
treatment
multisite
fibrosis.
