Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 667 - 667

Published: June 6, 2024

Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic condition characterized by bone cell ischemia, necrosis, trabecular fracture, and clinical symptoms such as pain, collapse, joint dysfunction that can lead to disability. The disability rate ONFH very high, which imposes significant economic burden on both families society. Steroid-associated osteonecrosis (SANFH) most common type ONFH. However, pathogenesis SANFH remains unclear, it an urgent challenge for surgeons explore it. In this paper, its related signaling pathways were briefly reviewed enhance comprehension prevention SANFH.

Language: Английский

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Ursonic Acid Ameliorates H2O2-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

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Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish Model

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is an early-onset neurodevelopmental and neurodegenerative disorder characterized by ataxia, spasticity, peripheral neuropathy. However, several studies have highlighted that some patients also experience cognitive, emotional social deficits, suggesting a more complex clinical picture extends beyond motor symptoms. Building on these findings, this study aimed to: i) investigate locomotor, cognitive deficits in adult sacs^-/- zebrafish versus wild-type (WT) controls through behavioural tests; ii) identify molecular patterns associated with the disease phenotype using transcriptomic proteomic analyses WT brains; iii) evaluate effectiveness long-term treatment tauroursodeoxycholic acid (TUDCA) outcomes omics profiles model. Our findings indicate impairments social, behaviors aged zebrafish, which resemble observed human patients. Transcriptomic brains identified alterations genes related to circadian rhythms neuroinflammation. Notably, disruptions sleep are frequently reported individuals cerebellar may contribute behavioral changes. Long-term TUDCA, neuroprotective molecule, was partial improvements modifications These results support potential further exploring TUDCA future preclinical studies, while emphasizing need for additional investigations better understand its mechanisms action.

Language: Английский

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Emerging Roles of Bile Acids and TGR5 in the Central Nervous System: Molecular Functions and Therapeutic Implications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9279 - 9279

Published: Aug. 27, 2024

Bile acids (BAs) are cholesterol derivatives synthesized in the liver and released into digestive tract to facilitate lipid uptake during digestion process. Most of these BAs reabsorbed recycled back liver. Some progress other tissues through bloodstream. The presence central nervous system (CNS) has been related their capacity cross blood–brain barrier (BBB) from systemic circulation. However, expression enzymes receptors involved synthesis signaling, respectively, support hypothesis that there is an endogenous source with a specific function CNS. Over last decades, have tested as treatments for many CNS pathologies, beneficial effects. Although they were initially reported neuroprotective substances, also known reduce inflammatory processes. effects activation Takeda G protein-coupled receptor 5 (TGR5). This review addresses new challenges face BA research neuroscience, focusing on molecular functions. We discuss exogenous sources CNS, signaling TGR5 receptor, mechanisms action potential therapeutics neuropathologies.

Language: Английский

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7,8-DHF Inhibits BMSC Oxidative Stress via the TRKB/PI3K/AKT/NRF2 Pathway to Improve Symptoms of Postmenopausal Osteoporosis

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 413 - 429

Published: Aug. 16, 2024

Postmenopausal osteoporosis (PMO) is characterized by bone loss and microstructural damage, it most common in older adult women. Currently, there no cure for PMO. The flavonoid chemical 7,8-dihydroxyflavone (7,8-DHF) specifically activates tropomyosin receptor kinase B (TRKB). Furthermore, 7,8-DHF has various biological characteristics, including anti-inflammatory antioxidant effects. However, the specific implications fundamental mechanisms of PMO remain unclear. We used protein imprinting, flow cytometry, tissue staining, other methods to estimate preventive against hydrogen peroxide (H

Language: Английский

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Research Progress on Oxidative Stress in the Pathogenesis of Steroid-Induced Osteonecrosis of the Femoral Head

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(04), P. 526 - 533

Published: Jan. 1, 2024

Language: Английский

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Combined Treatment with Tauroursodeoxycholic Acid and SCD Probiotics Reduces Oxidative Stress in Lung Tissue of Aged Rats

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Aging is associated with an increased level of oxidative stress, resulting from elevated production reactive oxygen species, which can lead to cellular and tissue damage, particularly in the lungs. This study examined effects Tauroursodeoxycholic acid (TUDCA) SCD Probiotics, both individually combination, on stress markers lung aged Sprague-Dawley rats. The primary objective was assess potential these agents reducing malondialdehyde (MDA), advanced oxidation protein products (AOPP), myeloperoxidase (MPO) levels, are indicative damage inflammation. results showed that TUDCA significantly decreased MDA AOPP suggesting its role maintaining mitochondrial stability inhibiting apoptotic pathways. Probiotics also demonstrated a reduction highlighting their immunomodulatory antioxidant effects. Furthermore, combined treatment led more pronounced decrease along significant MPO activity. suggests synergistic interaction enhances antioxidative anti-inflammatory properties individual treatments. These findings support therapeutic mitigating aging tissues, proposing concurrent use could be effective strategy against age-related stress. Further research warranted explore across different models long-term applications.

Language: Английский

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Bibliometric analysis of nanotechnology in spinal cord injury: current status and emerging frontiers

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 11, 2024

Objective The objective of this study was to analyze the impact nanotechnology on treatment and recovery spinal cord injury (SCI), a condition that has profound global effects physical psychological health. Methods We utilized Web Science Core Collection obtain bibliometric data. With tools such as VOSviewer CiteSpace, we conducted comprehensive review 422 relevant publications identify research trends influential works in field applied SCI. Results analysis revealed significant contributions from both China, Sweden United States, pinpointed inflammation, apoptosis, nano-drug delivery primary areas focus current research, with emerging evident recent literature. Conclusion Nanotechnology hold great potential revolutionize SCI through targeted therapeutics modulation pathological processes. This provided valuable insights into evolving landscape underscoring importance continuous innovation interdisciplinary collaboration.

Language: Английский

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