Cannabis and cancer: unveiling the potential of a green ally in breast, colorectal, and prostate cancer DOI Creative Commons
Husam ALSalamat,

Sara Feras Abuarab,

Hazem Mohamed Salamah

et al.

Journal of Cannabis Research, Journal Year: 2024, Volume and Issue: 6(1)

Published: May 16, 2024

Abstract Cancer comes in second place on the list of causes death worldwide. In 2018, 5-year prevalence breast cancer (BC), prostate (PC), and colorectal (CRC) were 30%, 12.3%, 10.9%, respectively. Cannabinoids are chemicals derived from Cannabis sativa plant; most investigated cannabinoids cannabinol, delta 9-tetrahydrocannabinol (Δ 9 -THC), cannabidiol. humans, endogenous endocannabinoid system consists endocannabinoids, receptors (CBs), enzymes that degrade endocannabinoids. this review, we will review recent literature for evidence discusses role cannabis treatment three types neoplasms mentioned. Studies have proved BC cells express CB receptors; many in- vivo studies showed cause apoptosis inhibit proliferation migration. Also, researchers found treating mice with THC JWH-133 (CB2 receptor agonist) slowed tumor growth. Regarding CRC, cannabidiol was to decrease viability chemotherapy-resistant CRC metastasis by antagonizing G-protein-coupled 55 (GPR55; a novel cannabinoid receptor) necessary metastasis. Moreover, had anti-angiogenetic effects reducing expression vascular endothelial growth factor (VEGF) addition anti-inflammatory effects. Finally, demonstrated PC highly CB1 CB2 capable inhibiting release exosomes microvesicles related progression. also antiproliferative, anti-invasive, anti-fibroblastic, cell cycle arrest, proapoptotic cells.

Language: Английский

Cannabis and cancer: unveiling the potential of a green ally in breast, colorectal, and prostate cancer DOI Creative Commons
Husam ALSalamat,

Sara Feras Abuarab,

Hazem Mohamed Salamah

et al.

Journal of Cannabis Research, Journal Year: 2024, Volume and Issue: 6(1)

Published: May 16, 2024

Abstract Cancer comes in second place on the list of causes death worldwide. In 2018, 5-year prevalence breast cancer (BC), prostate (PC), and colorectal (CRC) were 30%, 12.3%, 10.9%, respectively. Cannabinoids are chemicals derived from Cannabis sativa plant; most investigated cannabinoids cannabinol, delta 9-tetrahydrocannabinol (Δ 9 -THC), cannabidiol. humans, endogenous endocannabinoid system consists endocannabinoids, receptors (CBs), enzymes that degrade endocannabinoids. this review, we will review recent literature for evidence discusses role cannabis treatment three types neoplasms mentioned. Studies have proved BC cells express CB receptors; many in- vivo studies showed cause apoptosis inhibit proliferation migration. Also, researchers found treating mice with THC JWH-133 (CB2 receptor agonist) slowed tumor growth. Regarding CRC, cannabidiol was to decrease viability chemotherapy-resistant CRC metastasis by antagonizing G-protein-coupled 55 (GPR55; a novel cannabinoid receptor) necessary metastasis. Moreover, had anti-angiogenetic effects reducing expression vascular endothelial growth factor (VEGF) addition anti-inflammatory effects. Finally, demonstrated PC highly CB1 CB2 capable inhibiting release exosomes microvesicles related progression. also antiproliferative, anti-invasive, anti-fibroblastic, cell cycle arrest, proapoptotic cells.

Language: Английский

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