Myrtenol-loaded niosomes can prevent lung ischemia-reperfusion injury model in rats by balancing the Nrf2/Keap1 and NF-κB signaling pathways

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Optimal Timing of Exercise for Enhanced Learning and Memory: Insights From CA1 and CA3 Regions in Traumatic Brain Injury Model in Male Rats

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

ABSTRACT Objective Evidence suggests that exercise timing is crucial in reducing the impact of traumatic brain injury (TBI). The present study explores effects delayed and early on damage, cognitive dysfunction, anxiety behavior using an experimental TBI model. Methods We randomly assigned 36 male rats to six groups: control (sham, TBI), treadmill (24hA, 1‐month 24 h after 1WA (1‐month 1 week 1MB before 1MBA TBI). Results caused significant impairments behaviors, as well increased edema ( p < 0.05). groups showed improvement following order for impairments: > 24hA 1MB. Compared group, starting (24hA) significantly improved all variables except behavior. Exercise was more effective than other 0.05) problems, anxious behavior, damage. Conclusion Regular or a consistent routine TBI, such athletes, may provide most benefits from intervention TBI. Starting soon (within h) help protect against improve learning memory by cell death specific regions (CA1 CA3) also decreasing TNF‐α MDA compared later (1 after).

Language: Английский

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The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(5)

Published: May 1, 2025

ABSTRACT Background Asthma is a common chronic respiratory disease, and its potential association with the central nervous system has garnered increasing attention in recent years. While observational studies suggest that asthma may affect hippocampal structure function through mechanisms such as inflammation hypoxia, causal relationship remains unclear. Methods In this study, we employed two‐sample Mendelian randomization (MR) analysis, utilizing large‐scale genome‐wide study (GWAS) data to systematically investigate between volume. Data from GWAS of involving 155,386 individuals European ancestry imaging‐derived phenotypes (IDPs) volume 33,219 were analyzed. Results The results revealed significant negative correlation multiple IDPs ( P FDR < 0.05), indicating contribute reduced We identified 19 independent SNPs significantly associated 5×10⁻⁸), which 16 retained after clumping (r 2 0.001) harmonization. Sensitivity analyses no heterogeneity or horizontal pleiotropy, reverse MR analysis did not support effect on asthma. Conclusion Our provides genetic evidence for changes volume, highlighting need closer monitoring intervention neurocognitive health patients clinical practice. Future should explore brain structural across different racial groups subtypes, well underlying biological mechanisms.

Language: Английский

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The age-dependent impacts of treadmill exercise on cognitive impairments by reducing inflammation and oxidative stress in the hippocampus of morphine-exposed rats: the role of SIRTs 3 &4 and BDNF

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: May 26, 2025

Language: Английский

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Combination Therapy of Estrogen and Progesterone Attenuates Behavioral Impairments and Autophagy via circLrp1b/miR-27a-3p/Dram2 Pathway After Traumatic Brain Injury

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 29, 2025

Language: Английский

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Lactobacillus rhamnosus GG attenuates depression‐like behaviour and cognitive deficits in chronic ethanol exposure mice by down‐regulating systemic inflammatory factors

Addiction Biology, Journal Year: 2024, Volume and Issue: 29(11)

Published: Nov. 1, 2024

Abstract Ethanol can directly or indirectly lead to cognitive and mental disorders. The long‐term intake of alcohol affect the distribution gut microbiota. Lactobacillus rhamnosus GG (LGG) is a natural bacterium isolated from healthy human intestines that has function preventing cytokine‐induced cell apoptosis protecting barriers. However, regulatory effect LGG on disorders caused by chronic ethanol exposure (CEE) still unclear. In this study, we established CEE mouse model through free consumption added antibiotics in later stages model. Sequencing analysis 16S rRNA gene showed resulted decrease abundance diversity microbial communities accompanied alterations relative multiple enterobacterial genera. use alleviated depression‐like behaviour impairment CEE‐induced mice, reduced expression inflammatory factors such as interleukin (IL)‐6, IL‐1β tumour necrosis factor (TNF)‐α ileum, serum brain increased synaptophysin (SYN), postsynaptic density protein‐95 (PSD‐95) brain‐derived neurotrophic (BDNF) hippocampus. Together, alleviate mice while also improving memory functions reducing peripheral nervous system inflammation balancing

Language: Английский

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Myrtenol ameliorates inflammatory, oxidative, apoptotic, and hyperplasic effects of urethane-induced atypical adenomatous hyperplasia in the rat lung

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

Language: Английский

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Atomized inhalation of Icaritin reduces airway inflammation and remodeling in asthmatic mice

Journal of Asthma, Journal Year: 2024, Volume and Issue: 61(9), P. 930 - 939

Published: Jan. 31, 2024

Asthma is a disease characterized by airway hyperresponsiveness and inflammation. Icaritin (ICT) plant hormone with various pharmacological activities such as anti-inflammatory, immune regulation, anti-tumor. This study mainly explored the effects of nebulized inhalation ICT on inflammation remodeling in asthmatic mice.

Language: Английский

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Exploring the impact of acetylsalicylic acid and conditioned medium obtained from mesenchymal cells, individually and in combination, on cognitive function, histological changes, and oxidant–antioxidant balance in male rats with hippocampal injury

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(9)

Published: Sept. 1, 2024

Abstract Background The hippocampus is susceptible to damage, leading negative impacts on cognition. Conditioned medium (CM) obtained from adipose tissue–derived mesenchymal stem cells (MSCs) and acetylsalicylic acid (ASA) have shown neuroprotective effects independently. This study explored the synergistic potential of ASA CM adipose‐derived MSCs against hippocampal injury. Methods Adult male Wistar rats received bilateral ethidium bromide (EB) injections induce damage. Rats were treated with and/or derived tissue every 48 h for 16 days. Behavioral tests (open field test, Morris water maze, novel object recognition, passive avoidance), oxidative stress, Western blot analysis brain‐derived neurotrophic factor (BDNF) cerebral dopamine (CDNF) expression, histological investigation conducted. Results Administration EB caused impairments in spatial, avoidance memory, as well heightened reduced BDNF/CDNF pyramidal cell loss CA1 region. ASA, CM, or a combination both mitigated these damages cognitive deficits, elevated BDNF CDNF levels, alleviated necrosis by EB. Moreover, co‐administering resulted greater improvements spatial memory compared administering alone, suggesting possible interactions. Conclusions ability MSCs, their therapy alleviate injuries highlights promising therapeutic neuroprotection strategy brain Our findings provide preliminary evidence which warrants further investigations.

Language: Английский

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Myrtenol’s Effectiveness against Hospital‐Acquired Methicillin‐Resistant Staphylococcus aureus: Targeting Antibiofilm and Antivirulence Properties

International Journal of Microbiology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

The emergence of methicillin-resistant

Language: Английский

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