International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113598 - 113598
Published: Nov. 20, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Language: Английский
Citations
56
Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 11, 2025
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
Atherosclerosis (AS)-related cardiovascular disease and depression are often comorbid, with patients facing an increased risk of depression, which worsens AS. Both diseases characterized by oxidative stress lipid metabolism disorders. Ferroptosis, a form cell death iron overload harmful peroxide accumulation, is found in various diseases, including AS depression. Consistent the deposition peroxidation (LPO) that characterize ferroptosis mechanism, disturbances also crucial pathogenic mechanisms The comorbid complex, posing challenges for clinical treatment. Chinese herbs hold significant potential owing to their multi-target pharmacological effects. Therefore, this review aims investigate overload, LPO, across types, shared pathogenesis ferroptosis, research on herbal medicine targeting treatment anti-AS co-depression. This provides comprehensive understanding co-depression from perspective ferroptosis.
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: March 19, 2025
Ferroptosis, a newly identified form of cell death, is characterized by excessive iron accumulation and lipid peroxidation. Studies indicate strong association between ferroptosis depression; however, the precise signaling pathways underlying molecular mechanisms remain unclear. This review summarizes role in depression its associated pathways. Additionally, therapeutic approaches for based on theory are reviewed, providing novel targets prevention treatment laying foundation future research relationship depression.
Language: Английский
Citations
0
Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: April 23, 2025
Major depressive disorder (MDD) is one of the most common mental health conditions, characterized by pervasive and persistent low mood, self-esteem, a loss interest or pleasure in activities that are typically enjoyable. Despite decades research into etiology pathophysiological mechanisms depression, therapeutic outcomes for many individuals remain less than expected. A promising new area focuses on stress-induced neuroinflammatory processes, such as excessive activation crosstalk microglia astrocytes central nervous system under stress, well elevated levels pro-inflammatory cytokines, which closely linked to onset progression depression. This review summarizes through neuroinflammation induces promotes development also highlights effective roles small molecules with anti-inflammatory activity treatment MDD. Understanding specific further impacts using technologies single-cell RNA sequencing elucidate subtypes interactions great importance developing more strategies
Language: Английский
Citations
0
Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский
Citations
0
Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown
Published: May 3, 2025
Language: Английский
Citations
0
Neurochemistry International, Journal Year: 2024, Volume and Issue: 176, P. 105728 - 105728
Published: March 30, 2024
Language: Английский
Citations
1
Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1969 - 1983
Published: Oct. 1, 2024
Anxiety disorders seriously impair patients' mental health and quality of life, with limited effectiveness current treatments. Dysregulation activating transcription factor 4 (ATF4) is involved in various diseases, but the research on its potential roles alleviating anxiety remains limited.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113598 - 113598
Published: Nov. 20, 2024
Language: Английский
Citations
0