Understanding Neurogenesis and Neuritogenesis via Molecular Insights, Gender Influence, and Therapeutic Implications: Intervention of Nanomaterials DOI

Anusha Sebastian,

Mohanraj Alias Ayyappan Shanmuganathan,

Chinmayee Tripathy

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Neurological disorders impact global health by affecting both central and peripheral nervous systems. Understanding the neurogenic processes, i.e., neurogenesis neuritogenesis, is of paramount importance in context system development regeneration as they hold promising therapeutic implications. Neurogenesis forms functional neurons from precursor cells, while neuritogenesis involves extending neurites for neuron connections. This review discusses how these processes are influenced genetics, epigenetics, neurotrophic factors, environment, neuroinflammation, neurotransmitters. It also covers gender-specific aspects their on brain plasticity, susceptibility to neurological disorders. Alterations under influence cytokines, growth neurotransmitters, aging, linked potential targets. Gender-specific effects pharmacological interventions, like SSRIs, TCAs, atypical antipsychotics, lithium, explored this review. Hormone-mediated BDNF PPAR-γ agonists, well variations efficacy tolerability MAOIs, AEDs, NMDA receptor modulators, ampakines, detailed accurate design. The nanotechnology's significant contribution neural tissue mending neurodegenerative disorders, enhancing neuronal connectivity, stem cell differentiation. Gold nanoparticles support hippocampal neurogenesis, other aid neurite outgrowth. Quantum dots nanolayered double hydroxides assist neuroregeneration, which improves drug delivery. responses nanomedicines designed enhance neuroregeneration have not been extensively investigated. However, we specified certain gender-related variables that should be taken into account during an aim improve efficacy. Further research could personalized treatments paving way novel approaches neuroscience.

Language: Английский

The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications DOI Open Access
Sehwan Kim, Un Ju Jung, Sang Ryong Kim

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 386 - 386

Published: Jan. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Language: Английский

Citations

5
The association between depression and thyroid function DOI Creative Commons

Yuhui Ma,

Miao Wang,

Zhishen Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

Emerging evidence indicated that depression is currently one of the most burdensome diseases worldwide, and it can lead to a variety functional physical impairments. However, studies estimated association between thyroid function remain sparse. We aimed investigate in American population.

Language: Английский

Citations

4
Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer’s Disease DOI

Subhasri Bogadi,

Mahendran Bhaskaran, Ravichandran Veerasamy

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion DOI Creative Commons
Roli Kushwaha, Shashikant Patel,

Yuvaraj Kotteeswaran

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 26, 2025

Cerebral ischemic preconditioning offers a promising strategy to enhance resilience severe insults. Unilateral common carotid artery occlusion (UCCAo) is valuable model simulate chronic cerebral hypoperfusion (CCH). This study explored UCCAo-induced CCH as stimulus induce tolerance against transient global ischemia (tGCI) induced by bilateral (BCCAo) in both male and female mice. We evaluated the effects of on neuroprotection recovery through behavioral, histopathological, molecular analyses. Laser Doppler Imaging (LDI) confirmed significant post-UCCAo. Preconditioning reduced mortality rates at days 1 7 post-surgery compared BCCAo, suggesting its neuroprotective potential. Neurodeficit scoring demonstrated protection preconditioned animals with aligning closer sham controls. Behavioral assays revealed improved motor cognitive outcomes groups, sex-specific differences evident dynamics. Molecular analyses indicated reactive astrocyte (GFAP) microglial (IBA1) activation animals, reflecting controlled glial responses. Sex-dependent variations markers hypoxia (Hif1a), autophagy (Becn1), neurogenesis (Sox2) highlighted neuroadaptive cellular influences resilience. enhanced synaptic plasticity upregulating PSD-95, synaptophysin BDNF levels. In addition, increased VEGF expression blood serum vascular remodeling angiogenesis. positions reliable for exploring mechanisms advance therapeutic strategies mitigating stroke.

Language: Английский

Citations

0
Artificial intelligence-driven prediction and validation of blood-brain barrier permeability and absorption, distribution, metabolism, excretion profiles in Natural Product Research Laboratory compounds DOI Creative Commons
Jai‐Sing Yang,

E.P. Huang,

Ken Ying-Kai Liao

et al.

Biomedicine, Journal Year: 2024, Volume and Issue: 14(4)

Published: Dec. 1, 2024

Introduction: Our previous research demonstrated that a large language model (LLM) based on the transformer architecture, specifically MegaMolBART encoder with an XGBoost classifier, effectively predicts blood-brain barrier (BBB) permeability of compounds. However, coefficients compounds can traverse this remain unclear. Additionally, absorption, distribution, metabolism, and excretion (ADME) characteristics substances obtained from Natural Product Research Laboratory (NPRL) at China Medical University Hospital (CMUH) have not yet been determined.

Language: Английский

Citations

1
Understanding Neurogenesis and Neuritogenesis via Molecular Insights, Gender Influence, and Therapeutic Implications: Intervention of Nanomaterials DOI

Anusha Sebastian,

Mohanraj Alias Ayyappan Shanmuganathan,

Chinmayee Tripathy

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Neurological disorders impact global health by affecting both central and peripheral nervous systems. Understanding the neurogenic processes, i.e., neurogenesis neuritogenesis, is of paramount importance in context system development regeneration as they hold promising therapeutic implications. Neurogenesis forms functional neurons from precursor cells, while neuritogenesis involves extending neurites for neuron connections. This review discusses how these processes are influenced genetics, epigenetics, neurotrophic factors, environment, neuroinflammation, neurotransmitters. It also covers gender-specific aspects their on brain plasticity, susceptibility to neurological disorders. Alterations under influence cytokines, growth neurotransmitters, aging, linked potential targets. Gender-specific effects pharmacological interventions, like SSRIs, TCAs, atypical antipsychotics, lithium, explored this review. Hormone-mediated BDNF PPAR-γ agonists, well variations efficacy tolerability MAOIs, AEDs, NMDA receptor modulators, ampakines, detailed accurate design. The nanotechnology's significant contribution neural tissue mending neurodegenerative disorders, enhancing neuronal connectivity, stem cell differentiation. Gold nanoparticles support hippocampal neurogenesis, other aid neurite outgrowth. Quantum dots nanolayered double hydroxides assist neuroregeneration, which improves drug delivery. responses nanomedicines designed enhance neuroregeneration have not been extensively investigated. However, we specified certain gender-related variables that should be taken into account during an aim improve efficacy. Further research could personalized treatments paving way novel approaches neuroscience.

Language: Английский

Citations

0