Single-cell RNA sequencing reveals S100A8/A9hi neutrophils-induced endothelial cell death and lymphocyte infiltration after ischemic stroke. DOI
Song Wang, Yutao Wang, Sichen Wang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 741, P. 151023 - 151023

Published: Nov. 19, 2024

Language: Английский

Extracellular cold-inducible RNA-binding protein in CNS injury: molecular insights and therapeutic approaches DOI Creative Commons

Dmitriy Lapin,

Archna Sharma, Ping Wang

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 21, 2025

Abstract Central nervous system (CNS) injuries, such as ischemic stroke (IS), intracerebral hemorrhage (ICH) and traumatic brain injury (TBI), are a significant global burden. The complex pathophysiology of CNS is comprised primary secondary injury. Inflammatory incited by damage-associated molecular patterns (DAMPs) which signal variety resident cells infiltrating immune cells. Extracellular cold-inducible RNA-binding protein (eCIRP) DAMP acts through multiple non-immune to promote inflammation. Despite the well-established role eCIRP in systemic sterile inflammation, its less elucidated. Recent literature suggests that pleiotropic inflammatory mediator also being evaluated clinical biomarker indicate prognosis injuries. This review provides broad overview injury, with focus on immune-mediated neuroinflammation. We then what known about mechanisms both non-CNS cells, identifying opportunities for further study. explore eCIRP’s potential prognostic marker severity outcome. Next, we provide an eCIRP-targeting therapeutics suggest strategies develop these agents ameliorate Finally, emphasize exploring novel mechanisms, aside from neuroinflammation, critical therapeutic target

Language: Английский

Citations

2
The role of astrocyte metabolic reprogramming in ischemic stroke (Review) DOI Creative Commons
Weixin Chen, Tangyou Mao, Rui Ma

et al.

International Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: 55(3)

Published: Jan. 21, 2025

Ischemic stroke, a leading cause of disability and mortality worldwide, is characterized by the sudden loss blood flow in specific area brain. Intravenous thrombolysis with recombinant tissue plasminogen activator only approved pharmacological treatment for acute ischemic stroke; however, aforementioned has significant clinical limitations, thus there an urgent need development novel mechanisms therapeutic strategies stroke. Astrocytes, abundant versatile cells central nervous system, offer crucial support to neurons nutritionally, structurally physically. They also contribute blood‑brain barrier formation regulate neuronal extracellular ion concentrations. Accumulated evidence revealed involvement astrocytes regulation host neurotransmitter metabolism, immune response repair, different metabolic characteristics can process suggesting that targeted astrocyte reprogramming may prognosis In present review, current understanding multifaceted along its regulatory factors pathways, as well promote polarization balance, which hold promise immunometabolism‑targeted therapies were summarized.

Language: Английский

Citations

1
The Role of Thrombo-inflammation in Ischemic Stroke: Focus on the Manipulation and Clinical Application DOI

Yuanfei Luo,

Weichen Dong, Linying Yuan

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Language: Английский

Citations

6
Neuroprotective mechanisms of microglia in ischemic stroke: a review focused on mitochondria DOI
Jianhua Gan, Xinyi Yang, Jianan Wu

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 1, 2025

Language: Английский

Citations

0
Poliumoside Exhibits Neuroprotective Effects against Cerebral Ischemia-Reperfusion Injury by Relieving Microglia-Mediated Neuronal Damage and Astrocytic Activation DOI
Li‐Ping Bai, Zeyuan Guan,

Jianwen Zhang

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Excessive activation of microglia contributes to neuronal damage and astrocytic during cerebral ischemia hypoxia. Poliumoside (Pol) is a caffeoylated phenylpropanoid glycoside with significant anti-inflammatory antioxidant functions. However, whether Pol can mediate microglia-mediated neurotoxicity in the ischemic brain remains nebulous. Here, ischemia-reperfusion injury (CI/RI) mouse model was conducted investigate Pol's role microglial neurotoxicity. We found that significantly reduced neurological deficits, infarction volume, CI/RI model. inhibited proinflammatory cytokines activation, while enhancing cytokines. Mechanistically, markedly suppressed Fstl1, NF-κB phosphorylation, Nlrp3-Asc-Caspase1 inflammasome. In oxygen-glucose-deprivation (OGD)-mediated BV2 microglia, Fstl1 overexpression enhanced activation. The conditioned medium Fstl1-overexpressed promoted injuries. treatment or pathway inhibition reversed Fstl1-mediated effects. conclusion, restrained microglia-modulated neuroinflammation hypoxic-ischemic by restraining Fstl1-NF-κB pathway.

Language: Английский

Citations

0
Acupuncture regulates astrocyte neurotoxic polarization to protect blood–brain barrier integrity in delayed thrombolysis through mediating ERK1/2/Cx43 axis DOI Creative Commons
Zhihui Zhang, Yu Gu, Zheng Huang

et al.

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Single-cell RNA sequencing reveals S100A8/A9hi neutrophils-induced endothelial cell death and lymphocyte infiltration after ischemic stroke. DOI
Song Wang, Yutao Wang, Sichen Wang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 741, P. 151023 - 151023

Published: Nov. 19, 2024

Language: Английский

Citations

1