Enhanced Wound Healing With β-Chitosan-Zinc Oxide Nanoparticles: Insights From Zebrafish Models DOI Open Access

Tharansia Ramachandran,

Karthik Ganesh Mohanraj,

Taniya Mary Martin

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Wound healing is a complex physiological process essential for the restoration of tissue integrity and function. Novel therapeutic approaches are urgently needed to enhance wound-healing outcomes. Nanotechnology, particularly zinc oxide nanoparticles, has shown promise due its antimicrobial, anti-inflammatory, regenerative properties. β-chitosan, derived from squid pens, possesses superior solubility bioactivity compared α-chitosan, making it valuable biomaterial biomedical applications. Through integration β-chitosan this study seeks use complementary properties both substances overcome present constraints in wound care treatments.

Language: Английский

Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives DOI Creative Commons
Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

Citations

2
Cerebellar Pathology in Forensic and Clinical Neuroscience DOI
Azhagu Madhavan Sivalingam,

Darshitha D Sureshkumar

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102697 - 102697

Published: Feb. 1, 2025

Language: Английский

Citations

0
IMPACT OF BOSINTHETICALY DERIVED β-CHITOSAN TITANIUM NANOPARTICLES ON THE ENHANCMENT OF CAUDAL FIN REGENERATION ZEBRAFISH MOD DOI

Isabel Benny,

Karthik Ganesh Mohanraj,

Taniya Mary Martin

et al.

BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, Journal Year: 2025, Volume and Issue: unknown, P. 250 - 258

Published: March 20, 2025

Background: Tissue regeneration is a crucial biological process with significant implications for developmental biology and regenerative medicine. Zebrafish (Danio rerio), known their remarkable abilities, serve as an excellent model studying tissue regeneration, particularly through the caudal fin model. Materials Methods: β-Chitosan-TiO₂ nanoparticles were biosynthesized using plant extracts microbial cultures. Characterization was performed SEM, UV-Vis FTIR. assessed post-amputation, nanoparticle treatment in 16 μg/L 32 μg/L. Regeneration analyzed via microscopic observation gene expression. Data statistically ANOVA, considering p < 0.05 significant. Results: exhibited uniform size, high stability, strong biocompatibility. treated showed significantly enhanced compared to controls. Gene expression analysis supported upregulation of markers. Regenerated length measurements dose-dependent improvement, optimal effects at moderate concentrations. No toxicity or abnormalities observed zebrafish. Statistical confirmed differences (p 0.05) between control groups, demonstrating NPs' potential regeneration. Conclusion: zebrafish by promoting cell proliferation angiogenesis without toxicity. These findings highlight biocompatible eco-friendly nanomaterial applications.

Language: Английский

Citations

0
A Recent Advances in Antimicrobial Activity of Green Synthesized Selenium Nanoparticle DOI Creative Commons

Durgadevi Ravi,

Bhuvaneshwari Gunasekar,

Vishwanathan Kaliyaperumal

et al.

OpenNano, Journal Year: 2024, Volume and Issue: 20, P. 100219 - 100219

Published: Nov. 1, 2024

Language: Английский

Citations

3
Enhanced Wound Healing With β-Chitosan-Zinc Oxide Nanoparticles: Insights From Zebrafish Models DOI Open Access

Tharansia Ramachandran,

Karthik Ganesh Mohanraj,

Taniya Mary Martin

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Wound healing is a complex physiological process essential for the restoration of tissue integrity and function. Novel therapeutic approaches are urgently needed to enhance wound-healing outcomes. Nanotechnology, particularly zinc oxide nanoparticles, has shown promise due its antimicrobial, anti-inflammatory, regenerative properties. β-chitosan, derived from squid pens, possesses superior solubility bioactivity compared α-chitosan, making it valuable biomaterial biomedical applications. Through integration β-chitosan this study seeks use complementary properties both substances overcome present constraints in wound care treatments.

Language: Английский

Citations

2