Ageing-associated gut dysbiosis deteriorates mouse cognition DOI Creative Commons

Huihui Ju,

Yile Zhou,

Wanting Wei

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Ageing is an independent factor for cognitive dysfunction. Ageing-associated alterations in the gut microbiota also affect cognition. The present study designed to investigate changes and their participation ageing-associated impairment. Both 10-week-old 18-month-old mice are used. Mouse cognition examined by novel object recognition T-maze tests. feces collected sequencing transplantation. Protein expression mouse intestine hippocampus studied using immunohistochemistry immunofluorescence staining. Senescent neurons induced hydrogen peroxide vitro. cell lysates used western blot analysis adenosine triphosphate (ATP) measurement. Our results show that exhibit dysfunction compared with young mice. In aged mice, transplanting of increases protein presence synaptophysin partially restores expressions mucin-2 E-cadherin reduced but increased Gut analyses reveal abundance microbe Bacilli-Lactobacillales-Lactobacillaceae-Lactobacillus restored Fecal transplantation serum level acetic acid Hydrogen stimulation induces senescence reduces levels acetyl-coenzyme A synthetase member 2 (ACSS2) primary neurons. Incubation upregulates ACSS2 further ATP production senescent summary, Lactobacillales, elevates level, improves function has therapeutic importance decline.

Language: Английский

Jiaotaiwan activates serum SCFAs and upregulates cAMP-PKA-CREB-BDNF signaling pathway for antidepressant effects: A multicenter, randomized, controlled study DOI Open Access

Mengnan Huang,

Yuanyuan He,

Tong Yang

et al.

Chinese Herbal Medicines, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Fundamental role of brain-organ interaction in behavior-driven holistic homeostasis DOI Creative Commons
Xinan Liu, Xulin Li, Peilei Shen

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

0
Interaction between Gut Microbiota and Medicinal Food Homology in Depression DOI Open Access
Yu Tian

Journal of Biosciences and Medicines, Journal Year: 2024, Volume and Issue: 12(11), P. 190 - 205

Published: Jan. 1, 2024

Language: Английский

Citations

0
Ageing-associated gut dysbiosis deteriorates mouse cognition DOI Creative Commons

Huihui Ju,

Yile Zhou,

Wanting Wei

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Ageing is an independent factor for cognitive dysfunction. Ageing-associated alterations in the gut microbiota also affect cognition. The present study designed to investigate changes and their participation ageing-associated impairment. Both 10-week-old 18-month-old mice are used. Mouse cognition examined by novel object recognition T-maze tests. feces collected sequencing transplantation. Protein expression mouse intestine hippocampus studied using immunohistochemistry immunofluorescence staining. Senescent neurons induced hydrogen peroxide vitro. cell lysates used western blot analysis adenosine triphosphate (ATP) measurement. Our results show that exhibit dysfunction compared with young mice. In aged mice, transplanting of increases protein presence synaptophysin partially restores expressions mucin-2 E-cadherin reduced but increased Gut analyses reveal abundance microbe Bacilli-Lactobacillales-Lactobacillaceae-Lactobacillus restored Fecal transplantation serum level acetic acid Hydrogen stimulation induces senescence reduces levels acetyl-coenzyme A synthetase member 2 (ACSS2) primary neurons. Incubation upregulates ACSS2 further ATP production senescent summary, Lactobacillales, elevates level, improves function has therapeutic importance decline.

Language: Английский

Citations

0