Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 24, 2025

Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly facilitating drug resistance. This article delves into emerging evidence linking exosomal lncRNAs to modulation resistance mechanisms cancers such ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these influence cancer cell survival, tumor microenvironment, chemotherapy efficacy. Additionally, review highlights potential therapeutic strategies targeting lncRNAs, proposing a new frontier overcoming By mapping interface resistance, this aims provide comprehensive understanding that could pave way innovative treatments improved patient outcomes female reproductive system cancers.

Language: Английский

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Liquid Biopsy in Pituitary Neuroendocrine Tumors—Potential Biomarkers for Diagnosis, Prognosis, and Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4058 - 4058

Published: April 25, 2025

Pituitary neuroendocrine tumors (PitNETs) are slow-growing neoplasms with various clinical presentations, often leading to diagnostic challenges. While neuroimaging assessment and histopathological evaluation remain the gold standard for diagnosis, emerging research highlights potential of liquid biopsy, mainly through analysis circulating non-coding RNAs (ncRNAs), as a promising prognostic tool. Recent studies have demonstrated distinct expression profiles in different types subtypes tumors, implications assessing tumor aggressiveness predicting treatment response. The current article summarizes data about biofluid markers implicated PitNET development, DNA (ctDNA), cell-free (cfRNA), cells (CTCs), exosomes. Many on genetic molecular tissue samples provide exciting information biology, but date, specific biopsy biomarkers still few. Over past years, certain understanding mechanisms involved pituitary tumorigenesis has been gained, including landscape genomic alterations, changes epigenetic profile, crucial molecules signaling pathways, RNA critical roles malignant transformation. Genetic characterization PitNETs could help distinguish between functional non-functional PitNETs, invasive non-invasive forms. Further required identify validate innovative or therapeutic targets treating PitNET. Integrating into workflows revolutionize management adenomas, enabling more personalized less strategies.

Language: Английский

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Harnessing Exosomes: A Brief Overview of Nature’s Nanocarriers and a Glimpse into Their Implications in Pituitary Neuroendocrine Tumors (PitNETs)

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 310 - 310

Published: April 28, 2025

The study of exosomes is currently an area major interest in the scientific world, especially after discovery their function as natural nanocarriers. Their intrinsic features regulating intricate intracellular pathways have put them spotlight last decade, and it has been considered that by harnessing them, future cellular communication therapeutic innovation will experience a breakthrough, leading to pioneering research. However, demonstrated various important roles, from conferring resistance viral infections human placenta transfer oncogenic signals between cells, reshaping metabolism, promoting angiogenesis, mediating immune evasion, serving biomarkers cancer diagnosis prognosis, having implications management certain diseases. Besides general overview nature’s nanocarriers functions, this article aims discuss PitNETs, since there many recent studies regarding clinical benefits biomolecular medicine.

Language: Английский

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Multi-organ transcriptomics provide insights into growth regulation in the Dongtingking crucian carp (Carassius auratus indigentiaus)

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: unknown, P. 101538 - 101538

Published: May 1, 2025

Language: Английский

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