Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases DOI Creative Commons
Dario Rusciano

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1957 - 1957

Published: Nov. 27, 2024

This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), diabetic retinopathy. EGCG, potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, neuroprotective effects, making it promising candidate for reducing oxidative stress inflammation ocular tissues. Forskolin, diterpene Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) provides neuroprotection. Both compounds target critical pathways involved disease progression, including stress, mitochondrial dysfunction, inflammation, offering complementary benefits. consolidates preclinical clinical studies, highlighting EGCG as adjunctive or alternative treatments diseases. Future research should explore synergistic effects these compounds, particularly combination therapies aimed at addressing multiple pathogenic mechanisms health.

Language: Английский

EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism DOI Open Access
Junzhou Chen,

Chibiao Yin,

Yilong Zhang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 547 - 547

Published: Jan. 31, 2025

Background: Ferroptosis is a regulated cell death process linked to various diseases. This study explored whether Epigallocatechin-3-gallate (EGCG), tea-derived antioxidant, could regulate ferroptosis alleviate dextran sulfate sodium (DSS)-induced colitis. Methods: A DSS-induced colitis model was used assess EGCG’s effects. markers, oxidative stress, and iron metabolism were evaluated, alongside Nrf2-GPX4 pathway activation ferritin (FTH/L) expression. Results: Iron dysregulation stress contributed by activating in colonic epithelial cells. EGCG supplementation inhibited ferroptosis, reducing damage. Mechanistically, activated the pathway, enhancing antioxidant defense, improved upregulating Conclusions: effectively suppressed colitis, highlighting its potential as inhibitor therapeutic agent.

Language: Английский

Citations

0
Resetting the aging clock through epigenetic reprogramming: Insights from natural products DOI
Xin Liu, Jing Feng,

Mingli Guo

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108850 - 108850

Published: April 1, 2025

Language: Английский

Citations

0
Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases DOI Creative Commons
Maria Carolina Jurcău, Anamaria Jurcău,

Radu Diaconu

et al.

Stresses, Journal Year: 2024, Volume and Issue: 4(4), P. 827 - 849

Published: Dec. 2, 2024

Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on involvement oxidative stress in their pathogenesis, most trials antioxidants failed. The reasons may relate low bioavailability used compounds or starting therapy late, when pathogenic cascades already induced irreversible damage. current review discusses sources central nervous system, reactive oxygen species pathogenesis Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, importance further improved delivery methods as well search biomarkers that could help early diagnosis hope finding more therapies these diseases.

Language: Английский

Citations

2
Health Benefits of Epigallocatechin Gallate and Forskolin with a Special Emphasis on Glaucoma and Other Retinal Diseases DOI Creative Commons
Dario Rusciano

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1957 - 1957

Published: Nov. 27, 2024

This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), diabetic retinopathy. EGCG, potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, neuroprotective effects, making it promising candidate for reducing oxidative stress inflammation ocular tissues. Forskolin, diterpene Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) provides neuroprotection. Both compounds target critical pathways involved disease progression, including stress, mitochondrial dysfunction, inflammation, offering complementary benefits. consolidates preclinical clinical studies, highlighting EGCG as adjunctive or alternative treatments diseases. Future research should explore synergistic effects these compounds, particularly combination therapies aimed at addressing multiple pathogenic mechanisms health.

Language: Английский

Citations

0