How Do Peripheral Neurons and Glial Cells Participate in Pain Alleviation by Physical Activity? DOI Creative Commons
Menachem Hanani

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 462 - 462

Published: March 20, 2025

Chronic pain is a global health problem with major socioeconomic implications. Drug therapy for chronic limited, prompting search non-pharmacological treatments. One such approach physical exercise, which has been found to be beneficial numerous issues. Research in recent years yielded considerable evidence the analgesic actions of exercise humans and experimental animals, but underlying mechanisms are far from clear. It was proposed that influences pathways by interacting immune system, mainly reducing inflammatory responses, release endogenous mediators another possibility. Exercise acts on neurons glial cells both central peripheral nervous systems. This review focuses periphery, emphasis possible glia–neuron interactions. Key topics include interactions Schwann axons (myelinated unmyelinated), satellite sensory ganglia, enteric cells, sympathetic system. An attempt made highlight several neurological diseases associated roles may play exercise-induced alleviation. Among fibromyalgia Charcot–Marie–Tooth disease. The hypothesis active skeletal muscles exert their effects system releasing myokines discussed.

Language: Английский

Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain DOI Creative Commons
Xiaohui Li, Yu‐Shan Huang,

Jinzhu Bai

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 21, 2025

Neuropathic pain is a common and severe type of chronic pain, its pathogenesis has not been fully defined. Increasing evidence shows that spinal astrocytes play indispensable roles in the occurrence development neuropathic pain. Most studies have suggested activated can crosstalk with other glial cells neurons through morphological functional changes, exacerbating However, reactive dual role. As defense mechanism, increasing neuroprotection stimulating neurogenesis. Studies demonstrated potentially beneficial role for astrocyte activation In addition, therapeutic mechanisms multiple drugs neuromodulatory techniques are thought to be related astrocytes. This review highlights recent advances significance astrocytes, emphasizing need better understanding their treatment

Language: Английский

Citations

0
How Do Peripheral Neurons and Glial Cells Participate in Pain Alleviation by Physical Activity? DOI Creative Commons
Menachem Hanani

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 462 - 462

Published: March 20, 2025

Chronic pain is a global health problem with major socioeconomic implications. Drug therapy for chronic limited, prompting search non-pharmacological treatments. One such approach physical exercise, which has been found to be beneficial numerous issues. Research in recent years yielded considerable evidence the analgesic actions of exercise humans and experimental animals, but underlying mechanisms are far from clear. It was proposed that influences pathways by interacting immune system, mainly reducing inflammatory responses, release endogenous mediators another possibility. Exercise acts on neurons glial cells both central peripheral nervous systems. This review focuses periphery, emphasis possible glia–neuron interactions. Key topics include interactions Schwann axons (myelinated unmyelinated), satellite sensory ganglia, enteric cells, sympathetic system. An attempt made highlight several neurological diseases associated roles may play exercise-induced alleviation. Among fibromyalgia Charcot–Marie–Tooth disease. The hypothesis active skeletal muscles exert their effects system releasing myokines discussed.

Language: Английский

Citations

0