Gi signaling controls microglial surveillance and neuronal synchronization DOI
Aletta M.R. van den Bosch, Jörg Hamann

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain DOI Creative Commons

Denisa Pîrșcoveanu,

Denissa Greta Olaru,

Dirk M. Hermann

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Multi-scale Neural Homeostasis Mechanisms: Insights into Neurodegenerative Diseases and Therapeutic Approaches, Including Exercise DOI Creative Commons
Ya Wang, Xuhui Chen, Cuntai Zhang

et al.

Advanced Exercise and Health Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mechanisms of astrocytic and microglial purinergic signaling in homeostatic regulation and implications for neurological disease DOI Creative Commons
Moawiah M. Naffaa

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Purinergic signaling, mediated by ATP and adenosine receptors, plays a crucial role in cellular communication homeostasis within the central nervous system (CNS), particularly regulating synaptic activity, glial cell functions, neuroplasticity. Glial cells, including astrocytes microglia, contribute to both short-term processes, such as neurotransmission neuroinflammation, long-term remodeling, tissue repair, behavioral adaptation. Dysregulation of purinergic signaling these cells has been implicated pathogenesis various neurodegenerative neuropsychiatric disorders. This article explores evolving concept synapse, highlighting active modulation emphasizing significance function responses conditions injury neurotoxicity. Specifically, it examines roles receptors—such P2X4, P2X7, P2Y1, P2Y12—in mediating key astrocytic microglial phagocytosis, plasticity, neuronal damage. Furthermore, discusses involvement receptors neurological disorders epilepsy, Alzheimer’s disease, Parkinson’s multiple sclerosis, ischemic stroke, Rett syndrome, autism spectrum disorder, well potential therapeutic strategies targeting mitigate inflammation, promote improve clinical outcomes.

Language: Английский

Citations

0
P2Y6 Receptor: A Promising Therapeutic Target for Atherosclerosis DOI
Lixia Li,

L. Lai,

Dan Qiu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177513 - 177513

Published: March 1, 2025

Language: Английский

Citations

0
Gi signaling controls microglial surveillance and neuronal synchronization DOI
Aletta M.R. van den Bosch, Jörg Hamann

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0