The role of ACSL4 in stroke: mechanisms and potential therapeutic target DOI Creative Commons
Bifang Zhuo, Chenyang Qin, Shizhe Deng

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Stroke, as a neurological disorder with poor overall prognosis, has long plagued the patients. Current stroke therapy lacks effective treatments. Ferroptosis emerged prominent subject of discourse across various maladies in recent years. As an emerging therapeutic target, notwithstanding its initial identification tumor cells associated brain diseases, it lately been recognized pivotal factor pathological progression stroke. Acyl-CoA synthetase long-chain family member 4 (ACSL4) is potential target and biomarker catalytic unsaturated fatty acids mediating ferroptosis Specifically, upregulation ACSL4 leads to heightened accumulation lipid peroxidation products reactive oxygen species (ROS), thereby exacerbating neuronal cells. present tissues involved multiple pathways ferroptosis. At present, pharmacological mechanisms targeting inhibit have found many drugs, but molecular are still exploratory stage. This paper introduces physiopathological mechanism current status research crosstalk epigenetics, summarizes application modern pharmacology research, discusses value field

Language: Английский

Neuroprotective triterpenoids from Astragalus membranaceus stems and leaves: Anti-inflammatory and anti-apoptotic mechanisms for memory improvement via in vivo and in vitro models DOI
Yan‐Gang Cheng, Jianli Li, Pei Li

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108492 - 108492

Published: April 1, 2025

Language: Английский

Citations

0
The role of ACSL4 in stroke: mechanisms and potential therapeutic target DOI Creative Commons
Bifang Zhuo, Chenyang Qin, Shizhe Deng

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Stroke, as a neurological disorder with poor overall prognosis, has long plagued the patients. Current stroke therapy lacks effective treatments. Ferroptosis emerged prominent subject of discourse across various maladies in recent years. As an emerging therapeutic target, notwithstanding its initial identification tumor cells associated brain diseases, it lately been recognized pivotal factor pathological progression stroke. Acyl-CoA synthetase long-chain family member 4 (ACSL4) is potential target and biomarker catalytic unsaturated fatty acids mediating ferroptosis Specifically, upregulation ACSL4 leads to heightened accumulation lipid peroxidation products reactive oxygen species (ROS), thereby exacerbating neuronal cells. present tissues involved multiple pathways ferroptosis. At present, pharmacological mechanisms targeting inhibit have found many drugs, but molecular are still exploratory stage. This paper introduces physiopathological mechanism current status research crosstalk epigenetics, summarizes application modern pharmacology research, discusses value field

Language: Английский

Citations

1