The role of KRT18 in lung adenocarcinoma development: integrative bioinformatics and experimental validation DOI Creative Commons
Yongjie Li, Min Zeng, Yanru Qin

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 27, 2024

Lung adenocarcinoma (LUAD) represents one of the most common subtypes lung cancer with high rates incidence and mortality, which contributes to substantial health economic demand across globe. Treatment today mainly consists surgery, radiotherapy, chemotherapy, but their efficacy in advanced stages is often suboptimal emphasizes clear need for new biomarkers therapeutic targets. Using comprehensive bioinformatics analyses consisting Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein (HPA) Clinical Proteomic Tumor Analysis Consortium (CPTAC), immune infiltration analysis functional enrichment analysis, single-cell we examined potential keratin 18 (KRT18) as a candidate biomarker LUAD. KRT18 was significantly elevated LUAD tissue relative normal adjacent (p < 0.05), its expression correlated poor clinical-pathological features inferior prognostic outcome. Furthermore, associated several populations cells, suggesting may contribute local tumor microenvironment potentially pathways evasion. Survival indicated that overall survival (OS), disease-specific (DSS), progression-free interval (PFI), reinforcing legitimacy tool (AUC = 0.846). Importantly, gene found KRT18-associated genes enriched lymphocyte differentiation response pathways, provides mechanistic insight into biological effects attributed KRT18. Notably, NU.1025 has demonstrated capability reversing KRT18-modulated oncogenic features, targeted strategies can be developed moving forward. In conclusion, our data demonstrate utility also serve target merit further investigation underlying functions roles clinic.

Language: Английский

The Interplay Between Endoplasmic Reticulum Stress and Ferroptosis in Neurological Diseases DOI

Tianyu Zhai,

Bingbing Wang,

Caizhen Shi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 10, 2025

Language: Английский

Citations

1
The Receptor for Advanced Glycation End-products in the Mouse Anterior Cingulate Cortex is Involved in Neuron‒Astrocyte Coupling in Chronic Inflammatory Pain and Anxiety Comorbidity DOI Creative Commons
Wei Jiang, Minmin Gong,

Lin‐Lin Shen

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Previous studies have shown that astrocyte activation in the anterior cingulate cortex (ACC), accompanied by upregulation of marker S100 calcium binding protein B (S100B), contributes to comorbid anxiety chronic inflammatory pain (CIP), but exact downstream mechanism is still being explored. The receptor for advanced glycation end-products (RAGE) plays an important role and psychosis recognizing ligands, including S100B. Therefore, we speculate RAGE may be involved regulation comorbidity between CIP Here, investigated potential correlation ACC using a mouse model complete Freund's adjuvant (CFA)-induced pain. We detected substantial expression neurons when anxiety-like behaviors occurred CFA-treated mice. inhibition decreased hyperexcitability alleviated both hyperalgesia Furthermore, found astrocytic S100B level increased over similar time course. Intra-ACC application or downregulation via suppression significantly affected levels relative Taken together, these findings suggest neuronal results from leads maintenance perception late phase after CFA injection, which partly explain neuron‒astrocyte coupling promotes comorbidity.

Language: Английский

Citations

0
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain DOI Creative Commons

Denisa Pîrșcoveanu,

Denissa Greta Olaru,

Dirk M. Hermann

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model DOI Creative Commons
Chong Liu, Yan Zhao, Wei Zhang

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 15, 2025

The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in literature. Numerous studies have demonstrated that activation epidermal growth factor receptor 4 (ErbB4) is crucial neuronal injury and regeneration processes. This study investigated role targeted ErbB4 through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), mitigating PS-MPs-induced injury. findings revealed significantly ameliorated cognitive behavioral deficits mice exposed to PS-MPs. Furthermore, E4A treatment upregulated expression dedicator cytokinesis 3 (DOCK3) Sirtuin (SIRT3) mitigated mitochondrial synaptic dysfunction within hippocampus PS-MPs-exposed mice. also diminished TLR4-NF-κB-NLRP3 signaling pathway, consequently reducing neuroinflammation. In vitro experiments partially alleviated hippocampal its effects microglial inflammation. conclusion, this indicate may mitigate damage subsequent neuroinflammation, thereby alleviating induced by PS-MPs exposure ameliorating dysfunction. These results offer valuable insights for development potential therapeutic strategies.

Language: Английский

Citations

0
Oculomics approaches using retinal imaging to predict mental health disorders: a systematic review and meta-analysis DOI
Hong Kyu Kim, Tae Keun Yoo

International Ophthalmology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 18, 2025

Language: Английский

Citations

0
Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study DOI
Wei Jin, Jie Zhao,

Kaiying Yang

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
The role of KRT18 in lung adenocarcinoma development: integrative bioinformatics and experimental validation DOI Creative Commons
Yongjie Li, Min Zeng, Yanru Qin

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 27, 2024

Lung adenocarcinoma (LUAD) represents one of the most common subtypes lung cancer with high rates incidence and mortality, which contributes to substantial health economic demand across globe. Treatment today mainly consists surgery, radiotherapy, chemotherapy, but their efficacy in advanced stages is often suboptimal emphasizes clear need for new biomarkers therapeutic targets. Using comprehensive bioinformatics analyses consisting Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein (HPA) Clinical Proteomic Tumor Analysis Consortium (CPTAC), immune infiltration analysis functional enrichment analysis, single-cell we examined potential keratin 18 (KRT18) as a candidate biomarker LUAD. KRT18 was significantly elevated LUAD tissue relative normal adjacent (p < 0.05), its expression correlated poor clinical-pathological features inferior prognostic outcome. Furthermore, associated several populations cells, suggesting may contribute local tumor microenvironment potentially pathways evasion. Survival indicated that overall survival (OS), disease-specific (DSS), progression-free interval (PFI), reinforcing legitimacy tool (AUC = 0.846). Importantly, gene found KRT18-associated genes enriched lymphocyte differentiation response pathways, provides mechanistic insight into biological effects attributed KRT18. Notably, NU.1025 has demonstrated capability reversing KRT18-modulated oncogenic features, targeted strategies can be developed moving forward. In conclusion, our data demonstrate utility also serve target merit further investigation underlying functions roles clinic.

Language: Английский

Citations

0