Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 7, 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and neuroinflammation, with no definitive cure currently available. The NLRP3 inflammasome, key mediator of has emerged as critical player in AD pathogenesis, contributing to the accumulation β-amyloid (Aβ) plaques, tau hyperphosphorylation, neuronal damage. This review explores mechanisms which inflammasome activated AD, including its interactions Aβ, tau, reactive oxygen species (ROS), pyroptosis. Additionally, it highlights role ubiquitin system, ion channels, autophagy, gut microbiota regulating activation. Therapeutic strategies targeting such IL-1β inhibitors, natural compounds, novel small molecules, are discussed promising approaches mitigate neuroinflammation slow progression. underscores potential inhibition therapeutic avenue for AD.
Language: Английский