Research Progress of Genomics Applications in Secondary Metabolites of Medicinal Plants: A Case Study in Safflower

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3867 - 3867

Published: April 19, 2025

Medicinal plants, recognized as significant natural resources, have gained prominence in response to the increasing global demand for herbal medicines, necessitating large-scale production of these plants and their derivatives. are exposed a variety internal external factors that interact influence biosynthesis accumulation secondary metabolites. With rapid development omics technologies such genomics, transcriptomics, proteomics, metabolomics, multi-omics become important tools revealing complexity functionality organisms. They conducive further uncovering biological activities metabolites medicinal clarifying molecular mechanisms underlying Also, artificial intelligence (AI) technology accelerates comprehensive utilization high-dimensional datasets offers transformative potential analysis. However, there is currently no systematic review summarizing genomic metabolite plants. Safflower (Carthamus tinctorius L.) has rich diverse bioactive flavonoids, among which Hydroxysafflor yellow A (HSYA) specific safflower emerging medication treating wide range diseases. Hence, progress been made study an excellent example regulation recent years. Here, we on understanding main at level, summarize various types contents, with particular focus flavonoids. This aims provide insight into regulatory from perspective genomics.

Language: Английский

Natural Products Modulating Mitophagy Implications for Cancer Therapy

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 255 - 282

Published: June 5, 2025

Mitochondrial dysfunction is a hallmark of cancer, contributing to tumorigenesis, and therapeutic resistance. Mitophagy, the selective removal damaged or dysfunctional mitochondria, plays crucial role in maintaining cellular homeostasis preventing accumulation stress. The dysregulation mitophagy cancer often leads promoting tumorigenesis hampering efficacy conventional therapies. Natural products like polyphenols, flavonoids, alkaloids, terpenoids influencing mitophagy, through AMP-activated protein kinase (AMPK), mTORC1, PINK1/Parkin-mediated pathways offer promising strategy restore mitochondrial enhance sensitivity cells treatment. In conclusion, understanding intricate interplay between natural provides insights into novel strategies for diseases associated with dysfunction.

Language: Английский