The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy DOI Creative Commons
Chengyu Xie, Nan Wu, Jiaojiao Guo

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 12, 2025

Neurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as form of cell death that is reliant on iron, has been closely linked various neurological conditions. The fundamental process underlying ferroptosis by the excessive buildup iron ions, which initiates lipid peroxidation processes leading cellular demise. Neurons, highly metabolically active cells, are susceptible oxidative stress, and imbalances in metabolism can directly initiate process. In neurodegenerative like Alzheimer’s disease Parkinson’s disease, driven accumulation represents connection. Although connection between diseases clear, clinical application still faces challenges, such precise regulation metabolism, development specific drugs, assessment efficacy. limited comprehension mechanism hinders personalized treatment approaches. Consequently, subsequent investigations must tackle these obstacles facilitate ferroptosis-associated therapies disorders. This article provides comprehensive overview most recent advancements regarding mechanisms ferroptosis. Subsequently, study investigates mechanistic contributions within nervous system. conclusion, we evaluate deliberate targeted therapeutic strategies associated with

Language: Английский

The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy DOI Creative Commons
Chengyu Xie, Nan Wu, Jiaojiao Guo

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 12, 2025

Neurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as form of cell death that is reliant on iron, has been closely linked various neurological conditions. The fundamental process underlying ferroptosis by the excessive buildup iron ions, which initiates lipid peroxidation processes leading cellular demise. Neurons, highly metabolically active cells, are susceptible oxidative stress, and imbalances in metabolism can directly initiate process. In neurodegenerative like Alzheimer’s disease Parkinson’s disease, driven accumulation represents connection. Although connection between diseases clear, clinical application still faces challenges, such precise regulation metabolism, development specific drugs, assessment efficacy. limited comprehension mechanism hinders personalized treatment approaches. Consequently, subsequent investigations must tackle these obstacles facilitate ferroptosis-associated therapies disorders. This article provides comprehensive overview most recent advancements regarding mechanisms ferroptosis. Subsequently, study investigates mechanistic contributions within nervous system. conclusion, we evaluate deliberate targeted therapeutic strategies associated with

Language: Английский

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