From Nature to Nanomedicine: Enhancing the Antitumor Efficacy of Rhein, Curcumin, and Resveratrol DOI Creative Commons
Ana-Maria Trofin, Dragoş Viorel Scripcariu, Silviu Iulian Filipiuc

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(6), P. 981 - 981

Published: May 26, 2025

Natural compounds have garnered increasing interest as potential antitumor agents due to their multifaceted biological activities and relatively low toxicity profiles. This review focuses on three well-studied natural molecules: rhein, curcumin, resveratrol, analyzing comparing across a variety of cancer models. For each compound, we present an integrated perspective encompassing sources, physicochemical properties, pharmacological pharmacokinetic characteristics, the latest in vitro vivo evidence anticancer activity. Special attention is given molecular mechanisms underlying effects, including modulation cell cycle regulators, induction apoptosis, inhibition metastasis angiogenesis, regulation key signaling pathways such NF-κB, PI3K/Akt/mTOR, STAT3, MAPKs. Although numerous studies highlighted therapeutic promise, significant barriers remain—particularly related poor solubility limited bioavailability—which hindered clinical translation, especially case rhein. Advances nanotechnology-based drug delivery systems offer promising solutions these limitations, enabling improved targeting enhanced efficacy. underscores need for continued preclinical investigations fully elucidate value support integration into modern oncological treatment strategies.

Language: Английский

From Nature to Nanomedicine: Enhancing the Antitumor Efficacy of Rhein, Curcumin, and Resveratrol DOI Creative Commons
Ana-Maria Trofin, Dragoş Viorel Scripcariu, Silviu Iulian Filipiuc

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(6), P. 981 - 981

Published: May 26, 2025

Natural compounds have garnered increasing interest as potential antitumor agents due to their multifaceted biological activities and relatively low toxicity profiles. This review focuses on three well-studied natural molecules: rhein, curcumin, resveratrol, analyzing comparing across a variety of cancer models. For each compound, we present an integrated perspective encompassing sources, physicochemical properties, pharmacological pharmacokinetic characteristics, the latest in vitro vivo evidence anticancer activity. Special attention is given molecular mechanisms underlying effects, including modulation cell cycle regulators, induction apoptosis, inhibition metastasis angiogenesis, regulation key signaling pathways such NF-κB, PI3K/Akt/mTOR, STAT3, MAPKs. Although numerous studies highlighted therapeutic promise, significant barriers remain—particularly related poor solubility limited bioavailability—which hindered clinical translation, especially case rhein. Advances nanotechnology-based drug delivery systems offer promising solutions these limitations, enabling improved targeting enhanced efficacy. underscores need for continued preclinical investigations fully elucidate value support integration into modern oncological treatment strategies.

Language: Английский

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