Recent Advances in Catalytic Approaches for Pyrano[2,3‐c]Pyrazole Synthesis: Green and Sustainable Perspectives

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(12)

Published: March 1, 2025

Abstract This review provides a detailed look at the methods used to create pyrano[2,3‐c]pyrazole derivatives over past ten years, with focus on various catalytic techniques. The highlights progress in green chemistry, showing how catalysts such as homogeneous, heterogeneous, and nanoparticle types have been used. It also discusses new approaches like microwave‐assisted catalyst‐free synthesis. evaluates effectiveness of different based reaction efficiency, yield, sustainability. Furthermore, it explores eco‐friendly options bio‐catalysts ionic liquid catalysts, which offer scalable environmentally‐friendly for producing these important compounds. Pyrano[2,3‐c]pyrazoles were chosen their significant potential pharmaceuticals industry. emphasizes sustainable are becoming more modern particularly due reusability lower environmental impact, making them ideal industrial applications.

Language: Английский

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Green synthesis of pyrano[2,3-d]pyrimidine scaffolds in cetyltrimethylammonium bromide (CTAB) micellar media

Current Research in Green and Sustainable Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100456 - 100456

Published: May 1, 2025

Language: Английский

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Recent Advancement of 1,2,3,5‐Tetrakis(Carbazol‐9‐yl)‐4,6‐Dicyanobenzene (4‐CzIPN) in Photocatalyzed Synthesis of Heterocyclic Compounds

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(17)

Published: May 1, 2025

Abstract 4‐CzIPN is a traditional electron donor and acceptor fluorophore that uses carbazolyl as an donating dicyanobenzene withdrawing source. Its broad redox potential, high chemical resistance wide applicability makes it unique metal‐free photocatalyst. This study summarizes the recent development of photoredox catalyst for variety heterocyclic construction over last four years (2021‐2024).

Language: Английский

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Synthesis of Dihydropyrano[2,3- c ]pyrazoles with Trifluoroethanol as a Reusable Promoting Medium: A Green Protocol

Organic Preparations and Procedures International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: May 15, 2025

Language: Английский

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Halogenated dicyanobenzene-based photosensitizer (3DPAFIPN) as a thermally activated delayed fluorescence (TADF) used in gram-scale photosynthesis 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives via a consecutive visible-light-induced electron-transfer pathway

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: March 1, 2024

Background: Organic dyes often have shorter lifetimes in the excited state, which is a major obstacle to development of effective photoredox methods. The scientific community has shown great deal interest certain class organic chromophores because their unique characteristics and effectiveness. One characteristic molecules under research thermally activated delayed fluorescence (TADF), only observed with tiny energy gap (often less than 0.2 eV) between lowest two states, i.e., singlet state (S 1 ) triplet (T ). extended states arising from TADF simplicity redox potentials may be altered make isophthalonitrile family an attractive option for photocatalyst applications. Methods: Biginelli reaction β -ketoesters, arylaldehydes, urea/thiourea been used build sustainable technique production 3,4-dihydropyrimidin-2-(1 H )-one/thione derivatives. In present study, green radical synthesis approach this compounds addressed depth. As photocatalyst, new halogenated dicyanobenzene-based photosensitizer was employed study. renewable source by blue LED, it dissolved ethanol, at room temperature air atmosphere. primary objective employ novel donor-acceptor (D-A) based on cyanoarene that affordable, easily available, innovative. Findings: 3DPAFIPN [2,4,6-tris(diphenylamino)-5-fluoroisophthalonitrile] induces single-electron transfer (SET) response visible light, offering straightforward, eco-friendly, highly efficient process. Additionally, we determined derivatives turnover frequency (TOF) number (TON). It also demonstrated gram-scale cyclization workable method industrial purposes.

Language: Английский

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Aqueous TPGS-750-M-mediated synthesis of pyrano[2,3-c]-pyrazoles: a sustainable and efficient approach

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(6), P. 2827 - 2840

Published: April 23, 2024

Abstract The article describes a green and efficient synthesis method for pyrano[2,3-c]-pyrazoles, employing DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as biodegradable surfactant in water. utilization of water reaction medium TPGS-750-M obviates the necessity organic solvents, thereby enhancing environmental sustainability synthesis. compounds synthesized using this novel was characterized various spectroscopic techniques, including 1 H-NMR, 13 C-NMR, mass spectrometry. Graphical abstract

Language: Английский

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1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a reusable promoting medium for the catalyst-free and green synthesis of dihydropyrano[2,3-c]pyrazole scaffolds

Results in Chemistry, Journal Year: 2024, Volume and Issue: 9, P. 101629 - 101629

Published: July 1, 2024

A manufactured protocol that is both helpful and free of catalyst has been presented for the production dihydropyrano[2,3-c]pyrazole frameworks in polyfluorinated alcohol as a reusable promoting medium. All reactions are completed quickly, products obtained astounding yields. Notably, convenient approach remarkable yields, avoids use hazardous solvents or reagents, simple to operate, only requires one pot. The 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was extremely stable could be repeated four times without significant basic alteration action, making it ideal large-scale organic production.

Language: Английский

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9-mesityl-10-methylacridinium perchlorate (Mes-Acr-Me+ClO4−) as a novel metal-free donor–acceptor (D–A) photocatalyst: visible-light-induced access to tetrahydrobenzo[b]pyran scaffolds through a single-electron transfer (SET) pathway

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(7), P. 2993 - 3007

Published: May 20, 2024

Language: Английский

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Acridine Yellow G: A Photo-induced Electron Transfer Photocatalyst for the Radical Synthesis of Pyrano[2,3- d ]pyrimidines in an Aqueous Medium

Organic Preparations and Procedures International, Journal Year: 2024, Volume and Issue: 56(5), P. 419 - 428

Published: Feb. 7, 2024

Language: Английский

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Green Synthetic Approach for Catalyst-free Synthesis of 2-Amino-4 H -chromenes Promoted by Glycerol as a Reusable Medium

Organic Preparations and Procedures International, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 7

Published: June 5, 2024

Language: Английский

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