Field guide to Nath’s research work on ATP synthesis and hydrolysis

Biosystems, Journal Year: 2025, Volume and Issue: unknown, P. 105461 - 105461

Published: April 1, 2025

Adenosine triphosphate (ATP) is the universal biological energy source that participates in most prevalent chemical reactions all cell life through vital processes of oxidative phosphorylation (OXPHOS) and photosynthesis. Its synthesis utilisation an area basic research has seen significant progress over last three decades. A series Nath's publications 1990s culminated a detailed description molecular mechanism ATP FO F1 portions FOF1-ATP synthase which from transmembrane ion gradients are converted into F1. Subsequent papers provided thorough theoretical basis exploration validity new theory-named by other authors as torsional transduction two-ion theory coupling. Violation several physical laws previous theories have been dealt with considerable detail. In particular he reevaluated extensive literature on hydrolysis provides rigorously argued tri-site involving filled β-catalytic sites during F1/F1-ATPase. Numerous applications proposed throughout his work resulted four substantial dealing re-interpretation Warburg Effect cancer cells trilogy thermodynamics applied to problems comparative physiology, biochemistry ecology. Finally strict mathematical methods opened up approaches validate mechanistic events synthesis/hydrolysis. Here we provide field guide for easy access different aspects this body work.

Language: Английский

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Problematic issues of ATP synthesis in vivo

Biosystems, Journal Year: 2025, Volume and Issue: unknown, P. 105493 - 105493

Published: May 1, 2025

Language: Английский

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