Current status and future trends of the global burden of MASLD

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(8), P. 697 - 707

Published: Feb. 29, 2024

Language: Английский

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The global NAFLD policy review and preparedness index: Are countries ready to address this silent public health challenge?

Journal of Hepatology, Journal Year: 2021, Volume and Issue: 76(4), P. 771 - 780

Published: Dec. 9, 2021

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely underappreciated condition which closely associated with obesity and metabolic disease. Despite affecting an estimated 1 in 4 adults globally, NAFLD absent on national global health agendas.We collected data from 102 countries, accounting for 86% of the world population, policies, guidelines, civil society engagement, clinical management, epidemiologic data. A preparedness index was developed by coding questions into 6 domains (policies, awareness, epidemiology data, detection, care management) categorising responses as high, medium, low; multiple correspondence analysis then applied.The highest scoring countries were India (42.7) United Kingdom (40.0), 32 (31%) zero out 100. For 5 minority categorised high-level while majority low-level. No country had or sub-national strategy <2% different strategies related conditions included any mention NAFLD. National guidelines present only countries.Although pressing public problem, no found to be well prepared address it. There need at levels.Around third scored policy index, over 50/100. Although comprehensive response lacking all countries. Policies levels are urgently needed.

Language: Английский

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Global Prevalence and Clinical Characteristics of Metabolic-associated Fatty Liver Disease: A Meta-Analysis and Systematic Review of 10 739 607 Individuals

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2022, Volume and Issue: 107(9), P. 2691 - 2700

Published: May 19, 2022

Abstract Background and Aims Metabolic-associated fatty liver disease (MAFLD) was proposed as a better definition of nonalcoholic (NAFLD) to encompass the metabolic dysregulation associated with NAFLD. This redefinition challenges our understanding disease. Hence, this study sought conduct an updated analysis prevalence, clinical characteristics, factors MAFLD, further sensitivity done based on lean nonobese MAFLD individuals. Methods Medline Embase databases were searched include articles MAFLD. Meta-analysis proportions conducted using generalized linear mix model. Associating evaluated in conventional pairwise meta-analysis Results From pooled involving 3 320 108 individuals, overall prevalence 38.77% (95% CI 32.94% 44.95%); 5.37% 4.36% 6.59%) 29.78% 26.06% 33.79%) respectively, had Metabolic complications such hypertension [odds ratio (OR) 2.63, 95% 1.85 3.74, P &lt; 0.0001 OR 2.03; 1.74 2.38, 0.0001, respectively] diabetes (OR 3.80, 2.65 5.43, 3.46, 2.81 4.27, respectively) found significant associating Conclusions supports previous studies reporting affect more than third global population. While exploration pathogenic basis without is required, emphasis management concomitant can improve multidisciplinary efforts managing complex

Language: Английский

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Metabolic (dysfunction)-associated fatty liver disease in individuals of normal weight

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 19(10), P. 638 - 651

Published: June 16, 2022

Language: Английский

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The associations between modifiable risk factors and nonalcoholic fatty liver disease: A comprehensive Mendelian randomization study

Hepatology, Journal Year: 2022, Volume and Issue: 77(3), P. 949 - 964

Published: Aug. 16, 2022

Background and Aims: Early identification of modifiable risk factors is essential for the prevention nonalcoholic fatty liver disease (NAFLD). We aimed to systematically explore relationships between genetically predicted NAFLD. Approach Results: applied univariable multivariable Mendelian randomization analyses 35 also evaluated combined results in three independent large genome‐wide association studies. Genetically alcohol frequency, elevated serum levels enzymes, triglycerides, C‐reactive protein, obesity traits, including body mass index, waist circumference, fat mass, were associated with increased risks NAFLD (all p < 0.05). Poor physical condition had a suggestive (odds ratio [OR] = 2.63, 0.042). instrumented type 2 diabetes (T2DM), hypothyroidism, hypertension all NAFLD, ORs (95% confidence interval) 1.508 (1.20–1.90), 13.08 (1.53–111.65), 3.11 (1.33–7.31) 1‐U increase log‐transformed odds, respectively. The positive associations T2DM remained significant analyses. from discovery two replication datasets further confirmed that poor condition, T2DM, significantly whereas higher education high‐density lipoprotein cholesterol (HDL‐cholesterol) could lower risk. Conclusions: an HDL‐cholesterol decreased

Language: Английский

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Estimating Global Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight or Obese Adults

Clinical Gastroenterology and Hepatology, Journal Year: 2021, Volume and Issue: 20(3), P. e573 - e582

Published: Feb. 21, 2021

Background & AimsMetabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from non-alcoholic (NAFLD). In this study, we aim to estimate the global prevalence of MAFLD specifically in overweight and obese adults general population by performing systematic review meta-analysis through mining existing epidemiological data on disease.MethodsWe searched Medline, Embase, Web Science, Cochrane google scholar database inception November, 2020. DerSimonian-Laird random-effects model with Logit transformation was performed for analysis. Sensitivity analysis meta-regression were used explore predictors pooled statistics high heterogeneity.ResultsWe identified 116 relevant studies comprised 2,667,052 participants an estimated as 50.7% (95% CI 46.9-54.4) among overweight/obese regardless diagnostic techniques. Ultrasound most commonly technique generating rate 51.3% CI, 49.1-53.4). Male (59.0%; 95% 52.0-65.6) had significantly higher than female (47.5%; 40.7-54.5). Interestingly, rates are comparable based classical NAFLD non-NAFLD population. The comorbidities such type 2 diabetes metabolic syndrome 19.7% 12.8-29.0) 57.5% 49.9-64.8), respectively.ConclusionsMAFLD has astonishingly adults. This calls attention dedicated action primary care physicians, specialists, health policy makers public alike. Metabolic disease. We heterogeneity. respectively.

Language: Английский

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4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes—2023

Diabetes Care, Journal Year: 2022, Volume and Issue: 46(Supplement_1), P. s49 - s67.2

Published: Dec. 12, 2022

The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to provide components diabetes care, general treatment goals guidelines, tools evaluate quality care. Members ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating Standards annually, or more frequently as warranted. For detailed description standards, statements, reports, well evidence-grading system full list Committee members, please refer Introduction Methodology. Readers who wish comment on invited do so at professional.diabetes.org/SOC.

Language: Английский

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Association of metabolic dysfunction-associated fatty liver disease with kidney disease

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(4), P. 259 - 268

Published: Jan. 10, 2022

Language: Английский

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Intestinal Barrier and Permeability in Health, Obesity and NAFLD

Biomedicines, Journal Year: 2021, Volume and Issue: 10(1), P. 83 - 83

Published: Dec. 31, 2021

The largest surface of the human body exposed to external environment is gut. At this level, intestinal barrier includes luminal microbes, mucin layer, gastrointestinal motility and secretion, enterocytes, immune cells, gut vascular barrier, liver barrier. A healthy characterized by selective permeability nutrients, metabolites, water, bacterial products, processes are governed cellular, neural, immune, hormonal factors. Disrupted (leaky syndrome) can represent a predisposing or aggravating condition in obesity metabolically associated steatosis (nonalcoholic fatty disease, NAFLD). In what follows, we describe morphological-functional features role major modifiers discuss recent evidence pointing key obesity/NAFLD.

Language: Английский

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Metabolic-associated Fatty Liver Disease (MAFLD): A Multi-systemic Disease Beyond the Liver

Journal of Clinical and Translational Hepatology, Journal Year: 2021, Volume and Issue: 10(2), P. 329 - 338

Published: Oct. 19, 2021

Nonalcoholic fatty liver disease (NAFLD) is a multisystemic clinical condition that presents with wide spectrum of extrahepatic manifestations, such as obesity, type 2 diabetes mellitus, metabolic syndrome, cardiovascular diseases, chronic kidney disease, malignancies, cognitive disorders, and polycystic ovarian syndrome. Among NAFLD patients, the most common mortality etiology followed by liver-related complications. Furthermore, severity diseases parallel to NAFLD. In practice, awareness associations concomitant major importance for initiating prompt timely screening multidisciplinary management spectrum. 2020, consensus from 22 countries redefined (dysfunction)-associated (MAFLD), which resulted in redefinition corresponding population. Although patients diagnosed MAFLD mostly overlap, populations are not identical. this review, we compared key between MAFLD.

Language: Английский

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