Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024)

Journal of Clinical and Translational Hepatology, Journal Year: 2024, Volume and Issue: 000(000), P. 000 - 000

Published: Nov. 4, 2024

With the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, dysfunction-associated non-alcoholic fatty liver disease has become most prevalent chronic disease. This condition frequently occurs Chinese patients with alcoholic hepatitis B. To address impending public health crisis its underlying issues, Society Hepatology Medical Association convened a panel clinical experts to revise update "Guideline prevention treatment (2018, China)". The new edition, titled for (Version 2024)", offers comprehensive recommendations on key including screening monitoring, diagnosis evaluation, treatment, follow-up steatotic Metabolic is now preferred English term used interchangeably Additionally, guideline emphasizes importance multidisciplinary collaboration among hepatologists other specialists manage cardiometabolic disorders effectively.

Language: Английский

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The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(2)

Published: Jan. 1, 2025

ABSTRACT Background Gamma‐glutamyl transferase (GGT) has been shown to have associations with several diseases including cancers. Previous studies investigated the effect of GGT levels on gastrointestinal (GI) cancer incidence. We aim systematically investigate these provide better insights into interrelationship between and GI Methods Online databases were searched find relevant investigating different levels' effects incidence cancers colorectal, esophageal, liver, pancreas, gastric, biliary duct Random‐effect meta‐analysis was conducted pool hazard ratios (HRs) quartiles (Qs) Results A total 26 included in final review, 12 which underwent that 11 million patients. Based meta‐analysis, Q4 patients had a 69% higher (HR 1.69, 95% CI 1.41–2.02, p ‐value < 0.001). The ratio significance also similar for Q3 1.22, 1.15–1.30, 0.001) Q2 1.10, 1.05–1.16, =0.002) GGT. Colorectal liver showed among Q2, Q3, compared Q1. In pancreas bile cancers, only significantly HR. statistically significant gastric Conclusion Higher correlate rates incidence, especially colorectal hepatic Future should this biomarker's potential role risk assessment digestive

Language: Английский

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Liver diseases: epidemiology, causes, trends and predictions

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Language: Английский

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Metabolic dysfunction-associated steatotic liver disease and extrahepatic gastrointestinal cancers

Metabolism, Journal Year: 2024, Volume and Issue: 160, P. 156014 - 156014

Published: Aug. 24, 2024

Language: Английский

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Reducing Premature Mortality from Cardiovascular Diseases in Low and Middle Income Countries: The Role of Polypill in Public Health Policy

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: 25, P. 200400 - 200400

Published: April 6, 2025

Premature deaths account for about half of all fatalities in developing countries. In low- and middle-income countries, cardiovascular diseases have consistently been the primary cause premature mortality men women during past three decades. Current evidence indicates that fixed-dose combination therapy, so-called Polypill, effectively reduces burden diseases, with greater benefits observed combinations include aspirin. Polypill demonstrates high adherence an acceptable safety profile, adverse drug events being comparable between groups receiving treatment those control group. Therefore, this paper advocates broader implementation low emphasizing its efficacy secondary prevention diseases. The strategy could also benefit high-risk special conditions, such as non-alcoholic fatty liver disease chronic kidney disease. cost-effectiveness potential to address health inequities countries underscore value a public strategy. Policymakers are encouraged consider viable option enhance outcomes reduce low-resource settings.

Language: Английский

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Methods and Validity Indicators for Measuring Adherence to Statins in Secondary Cardiovascular Prevention: A Systematic Review

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Background Adherence to statin therapy is crucial for reducing the recurrence of cardiovascular events. Numerous methods exist measure medication adherence, including those based on prescription data, patient self-report, counting, and direct methods. It important determine which these are appropriate use in clinical practice. This systematic review aimed identify used adherence persistence statins patients undergoing secondary prevention evaluate validity indicators Methods included studies reporting and/or prevention. Medline, Embase, Scopus databases were searched from inception February, 2025. Rayyan was study selection extraction data processes. Validity adherence/persistence collected, it reported. Risk bias method evaluated using COSMIN (Consensus-based Standards Selection Health Measurement Instruments) tool. Results A total 77 included. Regarding measurement, most frequently refill records (n = 55) self-report 20). Electronic monitoring 2), self-perceived by physician 1), pill counting 1) less Direct methods, HPLC-MS/MS, combination with other indirect 5). For measuring persistence, predominant 9), while three studies, one a standardized questionnaire. Several have different populations medications. Only provides MAT questionnaire specifically adapted statins. Conclusions The predominantly indirect, relying supply Pill electronic monitoring, measurement via LC-MS/MS commonly used. Persistence primarily measured through records. None validated, thus their not recommended. There need new validated tools, incorporating gender perspective, this population. Systematic registration: CRD42023463981.

Language: Английский

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Association of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stages 0–4: evidence from a large cohort study

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 28, 2025

The Cardiovascular-kidney-metabolic (CKM) syndrome is a health disorder caused by interactions between cardiovascular disease, kidney and metabolism-related risk factors. stress hyperglycemia ratio (SHR) has been shown to correlate with the prognosis of participants diabetes mellitus, heart failure, myocardial infarction. However, predictive value SHR in CKM population unclear requires further exploration. This study analyzed 19,345 from National Health Nutrition Examination Survey (1999–2018). was staged according American Heart Association (AHA) guidelines. calculated using fasting blood glucose (FBG) glycated hemoglobin type A1c (HbA1c). Participants were grouped into four quartiles based on SHR. primary secondary outcomes all-cause mortality mortality, respectively. Kaplan-Meier survival curves Cox proportional hazard regression models used evaluate association outcomes. Then, potential nonlinear relationship explored restricted cubic spline (RCS) analysis. We also performed subgroup analyses assess effects different variables. A total 2,736 deaths 699 recorded during median follow-up period 115 months. analysis revealed that quartile 2 had lowest for both (Log Rank P < 0.05). Multivariate demonstrated 2nd (HR = 0.84, 95% CI 0.73–0.97, 0.015) highest 4th 1.19, 1.03–1.37, 0.018), compared 1st group RCS curve U-shape points 0.89 0.91, strongly correlated population, high or low increasing death. index shows great predicting death this population.

Language: Английский

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Association between weight-adjusted waist index and carotid atherosclerotic plaque in patients with type 2 diabetes in the Chinese population

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 15, 2025

Language: Английский

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Choice of antihyprtensive therapy at varios stages of metabolically associated lever disease

Experimental and Clinical Gastroenterology, Journal Year: 2024, Volume and Issue: 11, P. 52 - 61

Published: March 26, 2024

Metabolic dysfunction associated steatatotic liver disease (MASLD) and hypertension are two chronic progressive diseases that require a comprehensive approach. The article discusses approaches to the appointment of hypotensive hypolipidemic therapy in patients with MASLD, depending on stage disease.

Language: Английский

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Association between dietary intake of carotenoids and metabolic dysfunction-associated fatty liver disease in US adults: National Health and Nutrition Examination Survey 2017–March 2020

Public Health Nutrition, Journal Year: 2024, Volume and Issue: 27(1)

Published: Jan. 1, 2024

Abstract Objective: To assess the relationship between dietary intake of α -carotene, β -cryptoxanthin, lycopene and lutein+zeaxanthin (LZ) occurrence metabolic dysfunction-associated fatty liver disease (MAFLD). Design: Cross-sectional study design. The MAFLD diagnosis was based on hepatic steatosis dysregulation. Carotenoid adjusted for using an energy-adjusted model. Logistic regression restricted cubic spline (RCS) analyses were used to relationships, with sensitivity analysis validate findings. Weighted quantile sum (WQS) explore combined effect these carotenoids MAFLD. Subgroup conducted identify population-specific associations. Setting: National Health Nutrition Examination Survey (NHANES) 2017–March 2020. Participants: This included 5098 individuals aged 18 years older. Results: After adjusting potential confounders, a weak inverse association observed -carotene intakes (all P value <0·05). highest quartile showed significantly lower compared lowest (OR = 0·65; 95 % CI: 0·44, 0·97). RCS that associated higher four carotenoids, excluding lycopene. Furthermore, WQS revealed negative carotenoid 0·95, 0·90, 1·00, 0·037). reduced in populations 50–69 years, females, physically active non-drinkers. Conclusion: Higher is occurrence. However, this varies among different ages, sexes lifestyles.

Language: Английский

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