Differential expression of cardiometabolic and inflammation markers and signaling pathways between overweight/obese Qatari adults with high and low plasma salivary α-amylase activity DOI Creative Commons
Olfa Khalifa,

Neyla S. Al-Akl,

Abdelilah Arredouani

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

Background The relationship between salivary α-amylase activity (sAAa) and susceptibility to cardiovascular disorders lacks a definitive consensus in available studies. To fill this knowledge gap, the present study endeavors investigate association among overweight/obese otherwise healthy Qatari adults. specifically categorizes participants based on their sAAa into high low subgroups, aiming provide more comprehensive understanding of potential link levels inflammation markers population. Methods Plasma samples 264 (Ow/Ob) were used quantify profile proteins germane cardiovascular, cardiometabolic, metabolism, organ damage (LsAAa) (HsAAa) subjects using Olink technology. Comprehensive statistical tools as well chemometric enrichments analyses identify differentially expressed (DEPs) associated signaling pathways cellular functions. Results A total ten DEPs detected, them five upregulated (QPCT, LCN2, PON2, DPP7, CRKL) while down regulated LsAAa subgroup compared HsAAa (ARG1, CTSH, SERPINB6, OSMR, ALDH3A). Functional enrichment analysis highlighted several relevant functions enriched DEPs, including myocardial dysfunction, disorder blood pressure, infraction, apoptosis cardiomyocytes, hypertension, chronic inflammatory disorder, immunes-mediated disease, response, activation leukocytes phagocytes. Conclusion Our unveils substantial alterations within numerous canonical or molecular that bear relevance cardiometabolic Ow/Ob adults exhibiting plasma. exploration these offers prospect elucidating mechanistic underpinnings inherent documented metabolic disorders.

Language: Английский

Cardiovascular disease and metabolic dysfunction-associated steatotic liver disease: pathophysiology and diagnostic aspects DOI Creative Commons
Søren Møller, Nina Kimer, Jens D. Hove

et al.

European Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) can be interpreted as the hepatic expression of metabolic syndrome, which is estimated to affect 30% adult population. Obesity, dyslipidaemia, arterial hypertension, and T2DM are considered significant risk factors MASLD. The relationship two-way with MASLD found in up 75% patients T2DM. Importantly, associated increased cardiovascular diseases (CVD) such arrhythmia, atherosclerotic heart disease, failure, CVD-associated mortality. In addition, present a high prevalence major adverse cardiac events, calls for systematic surveillance CVD This review focuses on pathophysiology behind development MASLD, types complications, morbidity survival, suggestions evaluation

Language: Английский

Citations

2
Early and accurate diagnosis of steatotic liver by artificial intelligence (AI)-supported ultrasonography DOI
Sérgio Santoro, Mohamad Khalil,

Hala Abdallah

et al.

European Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 125, P. 57 - 66

Published: March 14, 2024

Language: Английский

Citations

10
Incident cardiac arrhythmias associated with metabolic dysfunction-associated steatotic liver disease: a nationwide histology cohort study DOI Creative Commons
Tracey G. Simon, Fahim Ebrahimi, Björn Roelstraete

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Dec. 13, 2023

Abstract Background Prior studies suggest a link between metabolic dysfunction-associated steatotic liver disease (MASLD) and incident arrhythmias, including atrial fibrillation (AF). However, robust data are lacking from cohorts with histology, which remains the gold standard for staging MASLD severity. Methods This population-based cohort included all Swedish adults histologically-confirmed without prior cardiac arrhythmias (1966–2016; n = 11,206). was defined prospectively-recorded histopathology, characterized as simple steatosis, non-fibrotic steatohepatitis (MASH), non-cirrhotic fibrosis, or cirrhosis. patients were matched to ≤ 5 controls by age, sex, calendar year county (n 51,856). Using Cox proportional hazards modeling, we calculated multivariable-adjusted hazard ratios (aHRs) (including AF, bradyarrhythmias, other supraventricular ventricular arrhythmias/cardiac arrest). Results Over median follow-up of 10.8 years, confirmed in 1351 (10.3/1000 person-years [PY]) 6493 (8.7/1000PY; difference 1.7/1000PY; aHR 1.30, 95%CI 1.22–1.38), had significantly higher rates AF (difference 0.9/1000PY; 1.26, 1.18–1.35). Rates both overall elevated across histological groups, particularly cirrhosis (differences, 8.5/1000PY 5.3/1000PY, respectively). In secondary analyses, also arrest (aHR 1.53, 1.30–1.80), bradyarrhythmias 1.06–1.48), 1.27, 1.00–1.62), compared controls. Conclusions Compared controls, biopsy-confirmed modest but incidence arrest. Excess risk observed stages highest

Language: Английский

Citations

11
Role of metabolic dysfunction-associated fatty liver disease in atrial fibrillation and heart failure: molecular and clinical aspects DOI Creative Commons
Jamie Cheung,

Bernard M.Y. Cheung,

Kai‐Hang Yiu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 8, 2025

Metabolic dysfunction-associated fatty liver disease (MASLD) is a rising global health concern. In addition to direct hepatic complications, extra-hepatic including cardiovascular diseases (CVD), type 2 diabetes (T2D), gastroesophageal reflux disease, chronic kidney and some malignancies, are increasingly recognized. CVD, atrial fibrillation (AF) heart failure (HF), the leading cause of death in patients with MASLD. External factors, excess energy intake, sedentary lifestyle xenobiotic use, induce inflammation-related complications. MASLD, AF, HF associated immune system activation, reprogramming cells establishment memory. Emerging evidence suggests that cross-talk each other through diverse spectrum autocrine, paracrine endocrine mechanisms. Pro-inflammatory cytokines produced from circulate systemically orchestrate metabolic derangements promote systematic dysregulation heart-liver axis development end-organ Cardio-hepatic syndrome describes clinical biochemical dysfunction cardiac pathology due interaction between liver. Activation inflammatory cascades, oxidative stress underlie key mechanisms bringing about such pathological changes. This review focuses on current molecular cross-talk. It summarizes epidemiological pathophysiological associations AF HF. addition, we will discuss how repurposing currently available emerging pharmacotherapies may help tackle risks resulting

Language: Английский

Citations

0
Cardiovascular disease assessment and management in liver transplantation DOI
Matthew E. Harinstein, Caterina Gandolfo, Salvatore Gruttadauria

et al.

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(41), P. 4399 - 4413

Published: Aug. 17, 2024

Abstract The prevalence and mortality related to end-stage liver disease (ESLD) continue rise globally. Liver transplant (LT) recipients be older have inherently more comorbidities. Among these, cardiac is one of the three main causes morbidity after LT. Several reasons exist including high associated risk factors, which can also attributed in proportion patients undergoing LT for metabolic dysfunction-associated steatohepatitis (MASH). Additionally, as people age, now treatable conditions, coronary artery (CAD), cardiomyopathies, significant valvular heart disease, pulmonary hypertension, arrhythmias rises, making need treat these conditions critical optimize outcomes. There an emerging body literature regarding CAD screening with ESLD, however, there a paucity strong evidence support guidance management pre-LT perioperative settings. This has resulted variations assessment strategies clinical candidates between centres, impacts candidacy based on centre's tolerance comfort level caring concomitant disease. Performing comprehensive understanding potential approaches ESLD may increase acceptance patients, who appear too complex, but rather require extra evaluation reasonable unique physiology profoundly influence preoperative assessment, management, outcomes underlying pathology, requires thoughtful multidisciplinary approach. proposed this manuscript attempt review latest expert experience opinions provide practicing clinicians assess being considered These topics highlight gaps that care future investigations field.

Language: Английский

Citations

3
Protective role of the CD73-A2AR axis in cirrhotic cardiomyopathy through negative feedback regulation of the NF-κB pathway DOI Creative Commons
Ning Zhao,

Zhenhao Shao,

Guoqing Xia

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 17, 2024

Myocardial inflammation and apoptosis induced by cirrhosis are among the primary mechanisms of cirrhotic cardiomyopathy. CD73, a common extracellular nucleotidase also known as 5'-nucleotidase, is associated with progression immunity in multiple organs. However, mechanism which CD73 contributes to myocardial remains unclear.

Language: Английский

Citations

2
Association of nonalcoholic fatty liver disease with new-onset atrial fibrillation stratified by age groups DOI Creative Commons
Eun Ju Cho, Goh Eun Chung, Jeong‐Ju Yoo

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 12, 2024

Language: Английский

Citations

2
Correlation between vascular endothelial function and bone mineral density in type 2 diabetes mellitus patients with MAFLD DOI

Peiyan Du,

Jianxiang Jiang,

Yu‐Rong Liu

et al.

Acta Cardiologica, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Dec. 10, 2024

Objective The relationship between vascular endothelial function and bone mineral density (BMD) in T2DM patients with metabolic dysfunction associated fatty liver (MAFLD) is still unclear. This study aims to analyse the correlation BMD or fracture risk MAFLD.

Language: Английский

Citations

2
Evaluation of Aortic Hemodynamics Using Four‐Dimensional Flow of Magnetic Resonance Imaging in Rabbits with Liver Fibrosis DOI
Jiali Li, Yuansheng Li, Xin Lin

et al.

Journal of Magnetic Resonance Imaging, Journal Year: 2024, Volume and Issue: 60(6), P. 2604 - 2612

Published: March 23, 2024

Background Liver fibrosis (LF) precipitates systemic hemodynamic alterations, however, its impact on the aorta remaining undefined. Purpose To assess hemodynamics changes during LF development in a rabbit model. Study Type Prospective, experimental. Animal Model Thirty 7‐month‐old male rabbits underwent bile duct ligation (BDL) to induce LF. Field Strength/Sequence Biweekly four‐dimensional (4D) flow imaging incorporating 3D gradient‐echo at 3.0 T scanner for 14 weeks post‐BDL. Assessment Histopathological exams 2–5 were performed each time point, following MRI scan. was graded using Metavir scale by pathologist. 4D analyzed two radiologists dedicated postprocessing software. They recorded parameters four sections (aortic sinus, before and after bifurcation of aortic arch, descending aorta). Statistical Tests The linear mixed model; Bonferroni correction; Pearson correlation coefficient ( r ); receiver operating characteristic (ROC) curve; Delong test. level significance set P < 0.05. Results Following BDL, wall shear stress (WSS) (0.23–0.32 Pa), energy loss (EL) (0.27–1.55 mW) significantly increased second week plane, peaking sixth (WSS: 0.35–0.49 Pa, EL: 0.57–2.0 mW). So did relative pressure difference (RPD) (second week: 1.67 ± 1.63 mmHg, 2.43 0.63 mmHg) plane 2. Notably, RPD 2 displayed highest area under ROC curve 0.998 (specificity: 1, sensitivity: 0.967). found second, fourth, with grade F2, F3, F4, respectively. most strongly correlated severity = 0.86). Data Conclusions occurrence could increase WSS, EL, as early BDL. Level Evidence 1 Technical Efficacy Stage

Language: Английский

Citations

1
Brain Lesions in Liver Cirrhosis May Not Only Be Due to Hepatic Encephalopathy DOI Creative Commons
Josef Finsterer

Journal of the Korean Society of Radiology, Journal Year: 2024, Volume and Issue: 85(4), P. 825 - 825

Published: Jan. 1, 2024

Language: Английский

Citations

0