The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

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Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Background Metabolic Dysfunction-Associated Fatty Liver disease (MAFLD) among lean individuals is increasingly recognized. We aimed to compare the prevalence, metabolic characteristics, and outcomes of vs overweight/obese-MAFLD patients. Methods Databases Embase, Medline, Web Science were searched from inception till October 2023. Only cohorts adhering lean-MAFLD criteria as defined by international consensus statement included. Results In pooled analysis 10,013,382 individuals, prevalence in general population was 1.94% (95% CI 1.10–3.39%, I 2 = 98.7%). Lean patients had similar characteristics for blood pressure, LDL, TG, glucose, HbA1c. There an increased incidence rate likelihood liver-related mortality [1.33 per 1000 patient-years 1.28–1.39) 0.76 0.25–2.28), (OR 3.56 3.45–3.67), p < 0.01). rates odds ratios between for: (1) all-cause [10.08 9.93–10.23) 8.94 4.08–19.57), 1.92 0.01–220.57), 0.33)]; (2) cardiovascular-related [2.53 0.65–9.96) 2.07 0.80–5.39), 1.91 0.02–142.76), 0.58)]; (3) cancer-related [3.42 3.33–3.51) 3.15 1.21–8.19), 1.99 0.29–13.52), 0.13). Conclusion Lean-MAFLD have equivalent burden compared thus a major extrahepatic complications. However, they risk mortality. Graphical abstract

Language: Английский

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Risk factor analysis and predictive model construction of lean MAFLD: a cross-sectional study of a health check-up population in China

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 25, 2025

Cardiovascular disease morbidity and mortality rates are high in patients with metabolic dysfunction-associated fatty liver (MAFLD). The objective of this study was to analyze the risk factors differences between lean MAFLD overweight MAFLD, establish validate a nomogram model for predicting MAFLD. This retrospective cross-sectional included 4363 participants who underwent annual health checkup at Yuyao from 2019 2022. population stratified into three groups: non-MAFLD, (defined as presence changes determined by ultrasound individuals BMI < 25 kg/m2), (BMI ≥ 25.0 kg/m2). Subsequent modeling analysis conducted that healthy subjects kg/m2 (n = 2104) 849). randomly split (7:3 ratio) training vs. validation cohort. Risk identify multivariate regression cohort, used construct estimate probability Model performance examined using receiver operating characteristic (ROC) curve k-fold cross-validation (k 5). Decision (DCA) applied evaluate clinical usefulness prediction model. indicated triglycerides glucose index (TyG) most significant factor (OR: 4.03, 95% CI 2.806–5.786). restricted cubic spline curves (RCS) demonstrated relationships systolic pressure (SBP), alanine aminotransferase (ALT), serum urate (UA), total cholesterol (TCHO), triglyceride (TG), index, density lipoprotein (HDLC), were nonlinear cutoff values different. constructed based on seven predictors: glycosylated hemoglobin A1c (HbA1c), ferritin (SF), ALT, UA, BMI, TyG age. In area under ROC 0.866 (95% 0.842–0.891), 83.8% sensitivity 76.6% specificity optimal cutoff. PPV NPV 63.3% 90.8%, respectively. Furthermore, we fivefold average (Figure S3). calibration model's predictions actual outcomes good agreement. DCA findings clinically useful throughout broad threshold range. Lean exhibit distinct profiles. developed is designed assist clinicians early identification high-risk including those normal but risk, well abnormal blood lipid, glucose, uric acid or transaminase levels. addition, enhances screening efforts communities medical centers, ultimately ensuring more timely effective services patients.

Language: Английский

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Heterogeneity of cardiometabolic and hepatic fibrosis risks in nonalcoholic fatty liver disease among lean, overweight, and obese populations: a multicenter cross-sectional study

European Journal of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Objective Given that cardiovascular events induced by metabolic disorders are the leading cause of death in nonalcoholic fatty liver disease (NAFLD), this study aimed to explore heterogeneity cardiometabolic and fibrosis risks among lean, overweight, obese NAFLD individuals. Methods A multicenter cross-sectional was conducted across three hospitals Pudong from July 2022 June 2023. Health checkup data were obtained stratified BMI categories. Multivariable logistic regression performed analyze association between risk factors for diseases different Results The included 37,122 patients, with 25.25% diagnosed NAFLD. Over 97% these patients met criteria dysfunction-associated disease. detection rates 7.72% 33.99% 63.56% Non-obese had significantly lower prevalence than ( P < 0.001). All subtypes, except lean (negatively associated total cholesterol) (no significant triglycerides), linked other or 0.05). Additioinally, only demonstrated a negative correlation age. Conclusion NAFLD, despite relatively better profile still poses risks. Interventions targeting progression essential all customized their characteristics. provide valuable reference estimating local prevalence.

Language: Английский

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The dynamic patterns of metabolic-associated fatty liver disease and its severity and risk of cardiovascular disease

Hepatology International, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Language: Английский

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