Update on the 2024 Guidelines by Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) on the Diagnosis and Management of Pediatric Acute Liver Failure DOI
Bikrant Bihari Lal, Seema Alam

Indian Pediatrics, Journal Year: 2024, Volume and Issue: 61(11), P. 1054 - 1058

Published: Oct. 22, 2024

Language: Английский

Role of therapeutic plasma exchange on survival in pediatric acute liver failure and acute-on chronic liver failure: A systematic review and meta-analysis DOI
Kalpana Panda,

Devi Prasad Dash,

Prateek Kumar Panda

et al.

Indian Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

1
Advancing non-invasive diagnostics for portal hypertension: promises and pitfalls DOI Creative Commons

Kiandokht Bashiri,

Atoosa Rabiee

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

0
Response to the Liver transplantation for pediatric acute liver failure: Need to think beyond King’s College hospital criteria and etiology! DOI
Viniyendra Pamecha, Nilesh Patil, Nihar Mohapatra

et al.

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0
Acute Liver Failure Due to Assumed Drug Induced Liver Injury but Lack of Any Validated Causality Algorithm: Evidence by 36 Cohort Reports with 21,709 Cases DOI Open Access
Rolf Teschke,

Axel Eickhoff

OBM Transplantation, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 10

Published: Feb. 14, 2025

Liver transplantation (LT) can be the only option for patients with acute liver failure (ALF) where medical approaches are ineffective. Causes of ALF multiple and commonly easily detectable, but uncertainty remained on role drug-induced injury (DILI) within published cohorts. Therefore, an analysis was undertaken to clarify which drugs may have caused DILI how diagnosis established. Using PubMed database Google Science, search term combined provided 36 publications cohorts, included 21,709 cases. Whereas non-drug causes were detectable by specific diagnostic biomarkers, among cohorts neglected, as evidenced lacking use a validated algorithm like Roussel Uclaf Causality Assessment Method (RUCAM), best qualified verify causality individual or drugs. This lack firm leads long list highly questionable suspected DILI, prevents calculation incidence prevalence data cannot help find appropriate therapy selected cases autoimmune hepatitis (DIAIH) overdosed N-acetyl-para-aminophenol (APAP) also known paracetamol, aiming prevent LT. Under discussion is high rate indeterminate up 78% confounds any quantitative approach in this setting. In conclusion, there much room improvement future requiring application tools.

Language: Английский

Citations

0
Bacterial and Fungal Infections in Pediatric Acute Liver Failure and Their Impact on Clinical Outcomes DOI
Tamoghna Biswas, Bikrant Bihari Lal, Vikrant Sood

et al.

The Pediatric Infectious Disease Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Objectives: The current study aimed to explore the prevalence, predictors and outcomes of infections in pediatric acute liver failure (PALF). Methods: Data were retrieved from a prospectively maintained database patients admitted with PALF between January 2012 June 2024. “Sepsis” was defined as presence systemic inflammatory response syndrome suspected or proven infection. Patients positive bacterial and/or fungal cultures labeled “culture-positive sepsis.” Outcome variables included native survival (NLS) overall (OS) at day 28. Results: A total 422 whom 195 (46.21%) fulfilled criteria sepsis 71 (16.8%) had culture-positive sepsis. Bronchoalveolar fluid (37/81, 45.7%) commonest site culture positivity followed by blood (29, 35.8%). More than 80% grew Gram-negative organisms high prevalence carbapenem (77.1%) multidrug (60%) resistance. These sensitive colistin newer beta-lactam combinations. Intensive care unit (ICU) stay, mechanical ventilation, grade 3–4 hepatic encephalopathy use extracorporeal support systems associated culture-negative lower NLS OS, whereas comparable without However, severe significantly lowered (33.3%) OS (42.9%) Conclusion: There is multidrug-resistant PALF. ICU stay are factors independently While did not affect survival, OS.

Language: Английский

Citations

0
Impact of plasma exchange on bilirubin reduction and neurological impairment in infantile acute liver failure DOI
Kentaro Ide, Hajime Uchida, Seisuke Sakamoto

et al.

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Plasma exchange to treat liver failure: The field expands DOI Creative Commons

Rohan Thomas,

C. E. Eapen

Indian Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
The role of plasmapheresis in acute liver failure due to Hepatitis A viral hepatitis DOI

Manjyot Luthra,

Nitika Agrawal,

Rakesh Kumar

et al.

Medical Journal Armed Forces India, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure DOI Creative Commons
Jian‐Hong Fang, Huichang Bi

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: 15(2), P. 1205 - 1206

Published: Feb. 1, 2025

Language: Английский

Citations

0
Understanding antituberculosis drug-induced hepatotoxicity: Risk factors and effective management strategies in the pediatric population DOI

Pooja Semwal,

Manjit Kaur Saini,

Moinak Sen Sarma

et al.

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

Antituberculosis drug-induced hepatotoxicity (ATDIH) is a significant concern while managing pediatric tuberculosis. There limited data on ATDIH, and much of the management practices are extrapolated from adult experiences. This article provides comprehensive overview incidence, risk factors, clinical presentation, strategies for ATDIH in children. Pyrazinamide, isoniazid, rifampicin most hepatotoxic first-line antituberculosis therapy (ATT). Though pyrazinamide has highest potential isoniazid frequently implicated. Hepatotoxicity typically manifests within first 2–8 weeks treatment, particularly during intensive phase. Risk factors include younger age, female gender, malnutrition, hypoalbuminemia, baseline liver dysfunction. Extra-pulmonary TB, tuberculous meningitis, concomitant medications such as antiretro viral or antiepileptic drugs further increase susceptibility. Genetic predisposition, including N-acetyltransferase 2 cytochrome P4502E1 polymorphisms specific HLA alleles also contribute to increased risk. Clinically, ranges asymptomatic transaminase elevation severe acute failure (ALF), necessitating prompt recognition intervention. Diagnosis relies temporal association injury with ATT initiation, supported by function tests, improvement upon cessation, recurrence reintroduction. Management involves discontinuing drugs, initiating non-hepatotoxic regimens, sequential reintroduction under close monitoring. For children ALF, care tertiary center transplantation expertise essential. While generally favorable outcomes timely intervention, delays can result morbidity mortality. Improved understanding vigilant monitoring protocols, standardized critical optimizing ATDIH.

Language: Английский

Citations

0