Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(6), P. 1357 - 1375
Published: June 14, 2023
Language: Английский
Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 37, P. 101644 - 101644
Published: Jan. 17, 2024
Exosomes are a type of extracellular vesicle that contains bioactive molecules can be secreted by most cells. Nevertheless, the content these cells differs depending on cell from which they originate. The exosome plays crucial role in modulating intercellular communication conveying molecular messages to neighboring or distant Cancer-derived exosomes transfer several types into tumor microenvironment, including high levels microRNA (miRNA). These miRNAs significantly affect proliferation, angiogenesis, apoptosis resistance, metastasis, and immune evasion. Increasing evidence indicates exosomal (exomiRs) regulating cancer resistance apoptosis. In cells, exomiRs orchestrate channels between them their surrounding gene expression controlling signaling pathways. This review presents an outline present-day knowledge mechanisms target drive Also, our study looks at regulatory mediating microenvironmental specifically stromal evade therapy-induced
Language: Английский
Citations
17
Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(4)
Published: March 1, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11356 - 11356
Published: July 12, 2023
This review article explores the possibility of developing an integrated approach to management different needs endometrial cancer (EC) patients seeking become pregnant. Life preservation woman, health baby, a precocious and—as much as possible—minimally invasive characterization and fertility parameters patient, together with concerns regarding obstetric, neonatal, adult risks children conceived via assisted reproductive techniques (ART) are all essential aspects problem be taken into consideration, yet harmonize such through concerted is still very challenging. aims illustrate main features EC how it affects normal physiology pre-menopausal women. We also focus on prospect miR-based, molecular evaluation patient status, including both early diagnosis staging and, similarly, receptivity discussing possible using single specific panel circulating miRs in thus allowing relatively fast, non-invasive testing significantly reduced margin error. Finally, ethical legal/regulatory innovative require not only risk-benefit analysis; respect for autonomy equitable care access allocation fundamental issues well.
Language: Английский
Citations
23
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 16054 - 16054
Published: Dec. 16, 2022
Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level insulin, plays crucial roles in development and progression diabetes, nonalcoholic fatty liver disease (NAFLD) other diseases. So far, distinct mechanism(s) IR still needs further exploration. Long non-coding RNA (lncRNA) is a class non-protein coding molecules with length greater than 200 nucleotides. LncRNAs are widely involved many biological processes including cell differentiation, proliferation, apoptosis metabolism. More recently, there has been increasing evidence that lncRNAs participated pathogenesis IR, dysregulated lncRNA profile played important metabolic diseases obesity, diabetes NAFLD. For example, MEG3, H19, MALAT1, GAS5, lncSHGL several have shown regulate signaling glucose/lipid metabolism various tissues. In this review, we briefly introduced general features methods for research, then summarized discussed recent advances on mechanisms particularly focused liver, skeletal muscle adipose
Language: Английский
Citations
24
Published: June 6, 2023
This review article is aimed at exploring the possibility of developing an integrated approach in management different needs endometrial cancer (EC) patients seeking to become pregnant. Life preservation woman, health baby, a precocious and – as much possible minimally invasive characterization fertility parameters patient, together with concerns regarding obstetric, neonatal, adult risks children conceived via assisted reproduction techniques (ART) are all essential aspects problem be taken into consideration, yet harmonize such through concerted still highly challenging. aims illustrate main features EC how it affects normal physiology pre-menopausal women. Then, we focus on prospect for miR-based, molecular evaluation patient status, including both early diagnosis staging and, similarly, receptivity discussing using single specific panel circulating miR thus allowing relatively fast, non-invasive way perform testing significantly reduced margin error. Finally, ethical legal/regulatory complexities arising from innovative require not only risk-benefit analysis; respect autonomy equitable care access allocation fundamental issues well.
Language: Английский
Citations
14
Experimental Gerontology, Journal Year: 2023, Volume and Issue: 182, P. 112287 - 112287
Published: Sept. 16, 2023
The gut microbiota is a complex microbial community that changes in response to various intestinal diseases, including aging-related diseases such as sarcopenia. Several studies have shown the metabolites of affect dynamic balance skeletal muscle. However, effect imbalance on sarcopenia still largely unknown.We collected baseline characteristics and fecal samples 14 patients with 21 without sarcopenia, used 16S rRNA sequencing technology analyze differences two groups. α-diversity β-diversity were employed assess abundance diversity species variations microflora composition, respectively. Moreover, Tax4Fun was predict functional capacities communities.In group, abundances beneficial bacteria Bacteroides, Faecalibacterium, Fusobacterium, Prevotella reduced, whereas those pathogenic bacteria, Escherichia-Shigella Klebsiella, increased. genera family Enterobacteriaceae main Klebsiella could be key biomarkers defective protein processing amino acid synthesis pathways indicated nutrient transport may damaged. been found negative correlation muscle mass parameters predicting change mass.In this study, we identified sarcopenic individuals, which linked loss function. conditional pathogen patients, its levels are significant mass.
Language: Английский
Citations
11
Cancer Reports, Journal Year: 2025, Volume and Issue: 8(4)
Published: April 1, 2025
ABSTRACT Introduction Suppression within the tumor microenvironment (TME) hampered natural killer (NK) cells and their role in cancer immunotherapy. This study explores how interleukin (IL) signaling (IL‐12A, IL‐12B, IL‐15, IL‐18) interferon gamma (IFNG or IFN‐γ) interact with microRNAs to regulate NK cell function cancer. Methods We identify targeted (miRNAs) for these genes key pathways influencing various cancers through comprehensive analyses, including protein–protein interaction networks, protein co‐expression, miRNA targeting prediction, homology, mRNA‐miRNA regulatory gene set enrichment, pathway analysis. Results Our analysis revealed a significant association between encoding interleukins IFNG infiltration across cancers. Additionally, we identified several miRNAs (hsa‐miR‐590‐3p, hsa‐miR‐340‐5p, hsa‐miR‐495‐3p, hsa‐miR‐5692a, hsa‐miR‐130a‐3p) that potentially by genes. These participate critical essential function. Notably, our findings suggest co‐regulation suppressing microenvironment. Conclusion highlights potential of as strategy enhance improve efficacy
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 5, 2024
Language: Английский
Citations
3
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 20, 2024
Language: Английский
Citations
3
The International Journal of Biochemistry & Cell Biology, Journal Year: 2024, Volume and Issue: 169, P. 106548 - 106548
Published: Feb. 13, 2024
Language: Английский
Citations
2