Construction of a disulfidptosis-associated lncRNA signature to predict prognosis in bladder cancer DOI Open Access
Jingsong Wang,

Qingyuan Zheng,

Jun Jian

et al.

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(12), P. 2705 - 2723

Published: Dec. 1, 2024

Bladder cancer (BCa) is the most common neoplasm of urinary system, and its high rates progression recurrence contribute to a generally poor prognosis, especially in advanced cases. It reported that disulfidptosis closely related with tumor proliferation. We aimed construct disulfidptosis-associated long non-coding RNA (lncRNA) signature can predict prognosis immune microenvironment BCa. obtained RNA-seq data, clinical information, mutation data BCa patients from The Cancer Genome Atlas (TCGA) database. Based on Pearson correlation uni-Cox regression analysis, we identified lncRNAs overall survival (OS). Then based seven was constructed by least absolute shrinkage selection operator (LASSO) Cox analysis multi-Cox analysis. performed Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA) analyses examine biological functional differentially expressed genes risk model. assessed chemotherapeutic response several drugs. Finally, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) used detect expression level lncRNAs. established (AP003419.3, AL161891.1, AC234917.3, LINC00536, AL021707.6, AL445649.1 AC104785.1). According signature, all were divided high- low-risk group showed significantly better prognosis. Moreover, model confirmed be an independent prognostic factor accuracy. Immune cells checkpoints more active high-risk this had higher burden (TMB) those group. results qRT-PCR demonstrated different between cell lines normal epithelial cells. lncRNA promising biomarker for predicting characterizing landscape BCa, potentially guiding personalized treatment strategies.

Language: Английский

Advances in epigenetic modifications and cervical cancer research DOI Creative Commons
Hui Liu, Huimin Ma, Yang Li

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188894 - 188894

Published: April 1, 2023

Cervical cancer (CC) is an important public health problem for women, and perspectives information regarding its prevention treatment are quickly evolving. Human papilloma virus (HPV) has been recognized as a major contributor to CC development; however, HPV infection not the only cause of CC. Epigenetics refers changes in gene expression levels caused by non-gene sequence changes. Growing evidence suggests that disruption patterns which were governed epigenetic modifications can result cancer, autoimmune diseases, various other maladies. This article mainly reviews current research status based on four aspects, respectively DNA methylation, histone modification, noncoding RNA regulation chromatin regulation, we also discuss their functions molecular mechanisms occurrence progression review provides new ideas early screening, risk assessment, targeted therapy prognostic prediction

Language: Английский

Citations

18
SLC7A11 in hepatocellular carcinoma: potential mechanisms, regulation, and clinical significance DOI Open Access
Tian-Ze Li, Jianwei Yi, Hua‐Jun Wu

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(5), P. 2326 - 2342

Published: Jan. 1, 2024

Exploring novel early detection biomarkers and developing more efficacious treatments remain pressing tasks in the current research landscape for hepatocellular carcinoma (HCC). Morphologically molecularly separate from apoptosis, cell death, autophagy, ferroptosis is a recently discovered, unique, controlled form of death. SLC7A11 (also known as xCT) represents subunit cystine-glutamate antiporter system Xc(-)). A growing body suggests that induction through can effectively eliminate (HCC) cells, particularly those exhibiting resistance to alternative forms Thus, targeting via may become new direction design therapeutic strategies HCC. Although many articles have investigated possible roles HCC, study summarizes main findings, including regulators mechanisms action HCC not available. Therefore, we present comprehensive overview functions ferroptosis, SLC7A11, identification, development, management this review. In addition, discuss how knowledge be translated into treatment by providing systemic therapy advanced using sorafenib, first-line drug multiple kinases SLC7A11. We further dissect barriers well corresponding solutions provide insights on navigate effective knowledge.

Language: Английский

Citations

8
Diagnostic and Predictive Value of LncRNA MCM3AP-AS1 in Sepsis and Its Regulatory Role in Sepsis-Induced Myocardial Dysfunction DOI
Yunwei Wei, Bai Cui, Shuying Xu

et al.

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(10), P. 1125 - 1138

Published: July 31, 2024

Language: Английский

Citations

4
Long noncoding RNA CASC11 suppresses sorafenib-triggered ferroptosis via stabilizing SLC7A11 mRNA in hepatocellular carcinoma cells DOI Creative Commons
Fei Chen, Liang Wang

Discover Oncology, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 8, 2023

As a frontline treatment for patients with advanced hepatocellular carcinoma (HCC), sorafenib is an effective drug approved by the Food and Drug Administration (FDA). Ferroptosis, newly defined programmed cell death process hallmark of accumulation iron-dependent lipid peroxides, can be induced treatment. Our previous study identified oncogenic roles long noncoding RNA (lncRNA) Cancer susceptibility candidate 11 (CASC11) in HCC progression. However, relationship between CASC11 sorafenib-induced ferroptosis remains unclear. In present study, we aim to investigate role lines determine involved molecular mechanisms. Here, demonstrated that decreased CASCL11 expression. Knockdown enhanced ferroptosis, while overexpression exerted opposite effect cells. Moreover, led intracellular malondialdehyde (MDA), reactive oxygen species (ROS) Fe2+ depleting glutathione (GSH), thereby suppressing death. Ferrostatin-1 (Ferr-1), inhibitor, reversed anticancer caused silence Mechanistically, upregulated expression solute carrier family 7 member (SLC7A11) which critical inhibition. associated stabilized SLC7A11 mRNA. summary, our data revealed, first time, inhibits cells via regulating SLC7A11, providing new basis clinical therapeutic strategies HCC.

Language: Английский

Citations

10
LncRNA MCM3AP-AS1 promotes chemoresistance in triple-negative breast cancer through the miR-524-5p/RBM39 axis DOI
Yueping Wang, Xuedong Wang,

Sun Haiyi

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Language: Английский

Citations

3
LncRNA XIST/miR-455-3p/HOXC4 axis promotes breast cancer development by activating TGF-β/SMAD signaling pathway DOI
Shanshan Zhao, Chen Song, Fengxi Chen

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Sept. 12, 2024

Language: Английский

Citations

3
LncRNA MALAT1 and Ischemic Stroke: Pathogenesis and Opportunities DOI

Seyed Esmaeil Khoshnam,

Arash Moalemnia,

Omid Anbiyaee

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(7), P. 4369 - 4380

Published: Dec. 12, 2023

Language: Английский

Citations

8
Advances in the study of biomarkers related to bone metastasis in breast cancer DOI

Dongcheng Xu,

Mingxing Tang

British Journal of Radiology, Journal Year: 2023, Volume and Issue: 96(1150)

Published: July 2, 2023

Breast cancer is by far the most common malignancy in females. And bone site of distant metastasis breast cancer, accounting for about 65 to 75% all metastatic patients.

Language: Английский

Citations

6
Construction of a disulfidptosis-associated lncRNA signature to predict prognosis in bladder cancer DOI Open Access
Jingsong Wang,

Qingyuan Zheng,

Jun Jian

et al.

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(12), P. 2705 - 2723

Published: Dec. 1, 2024

Bladder cancer (BCa) is the most common neoplasm of urinary system, and its high rates progression recurrence contribute to a generally poor prognosis, especially in advanced cases. It reported that disulfidptosis closely related with tumor proliferation. We aimed construct disulfidptosis-associated long non-coding RNA (lncRNA) signature can predict prognosis immune microenvironment BCa. obtained RNA-seq data, clinical information, mutation data BCa patients from The Cancer Genome Atlas (TCGA) database. Based on Pearson correlation uni-Cox regression analysis, we identified lncRNAs overall survival (OS). Then based seven was constructed by least absolute shrinkage selection operator (LASSO) Cox analysis multi-Cox analysis. performed Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA) analyses examine biological functional differentially expressed genes risk model. assessed chemotherapeutic response several drugs. Finally, quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) used detect expression level lncRNAs. established (AP003419.3, AL161891.1, AC234917.3, LINC00536, AL021707.6, AL445649.1 AC104785.1). According signature, all were divided high- low-risk group showed significantly better prognosis. Moreover, model confirmed be an independent prognostic factor accuracy. Immune cells checkpoints more active high-risk this had higher burden (TMB) those group. results qRT-PCR demonstrated different between cell lines normal epithelial cells. lncRNA promising biomarker for predicting characterizing landscape BCa, potentially guiding personalized treatment strategies.

Language: Английский

Citations

1