Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234

Published: May 20, 2024

Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.

Language: Английский

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Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional RNA, play crucial regulatory roles in variety biological processes. this manuscript, we review lncRNAs key aspects summarize research progress on ferroptosis-related

Language: Английский

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Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy

Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 15, 2025

Colorectal cancer (CRC) remains one of the most common causes cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), have been identified as key regulators gene expression, affecting diverse biological processes, notably programmed cell death (PCD). This review aims to explore relationship between ncRNAs PCD in CRC, focusing on how influence survival, proliferation, treatment resistance. A comprehensive literature analysis was conducted examine recent findings role modulating various mechanisms, apoptosis, autophagy, necroptosis, pyroptosis, their impact CRC development therapeutic response. were found significantly regulate pathways, impacting tumor growth, metastasis, sensitivity CRC. Their these pathways highlights potential biomarkers for early detection targets innovative interventions. Understanding involvement regulation offers new insights into biology. The targeted modulation ncRNA-PCD presents promising avenues personalized treatment, which may improve patient outcomes enhancing effectiveness reducing

Language: Английский

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Targeting ferroptosis regulators by natural products in colorectal cancer

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 27, 2024

Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation

Language: Английский

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OTUD6B-AS1: a multifaceted regulator of cancer with critical clinical implications

American Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(1), P. 1 - 18

Published: Jan. 1, 2025

OTU Deubiquitinase 6B-Antisense Transcript 1 (OTUD6B-AS1), a novel long non-coding RNA (lncRNA), has recently emerged as critical regulator in various tumors. Current research underscores its dual functionality, acting either an oncogene or tumor suppressor depending on the context. In this work, we compile and discuss findings from range of studies investigating expression patterns OTUD6B-AS1 different cancers consequent effects behavior, both vitro vivo. We delve into mechanisms through which influences cancer initiation progression, focusing role regulating essential cellular processes such cell growth, migration, invasion, angiogenesis, ferroptosis, treatment resistance. Operating complex interactions with microRNAs (miRNAs), proteins, pivotal signaling pathways - most notably Wnt/β-catenin exhibits variable roles across types environments. Additionally, assess clinical relevance levels, evaluating potential biomarker for prognosis diagnosis, well target therapeutic intervention. By consolidating existing knowledge, work aims to highlight implications encourage further oncology, ultimately contributing advancement targeted therapies.

Language: Английский

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Ferroptosis: the balance between death and survival in colorectal cancer

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(10), P. 3773 - 3783

Published: Jan. 1, 2024

Colorectal cancer (CRC) is a common malignant tumor associated with high morbidity and mortality.Despite an increase in early screening treatment options, people CRC still have poor prognosis low 5-year survival rate.Therefore, mining more therapeutic targets developing means of diagnosis determining are now imperative the clinical CRC.Ferroptosis recently identified type regulated cell death (RCD) characterized, which by accumulation iron-dependent lipid peroxidation, thereby causing membrane damage death.Recent studies shown that ferroptosis tumors, including CRC, can be involved progression; however, underlying mechanisms complex heterogeneous not been thoroughly summarized.Therefore, this study reviewed roles progression to target ferroptosis-related factors for treatment.The significance biomarkers genes was also investigated.Furthermore, limitations current as well future research perspectives, discussed.

Language: Английский

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Autophagy/ferroptosis in colorectal cancer: Carcinogenic view and nanoparticle-mediated cell death regulation

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117006 - 117006

Published: Sept. 3, 2023

Language: Английский

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Noncoding RNAs in cancer ferroptosis: From biology to clinical opportunity

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115053 - 115053

Published: June 28, 2023

Ferroptosis is a recently discovered pattern of programmed cell death that nonapoptotic and irondependent. It involved in lipid peroxidation dependent on reactive oxygen species. has been verified to play crucial regulatory role variety pathological courses disease, particularly cancer. Emerging research highlighted the potential ferroptosis tumorigenesis, cancer development resistance chemotherapy. However, mechanism remains unclear, which limits application treatment. Noncoding RNAs (ncRNAs) are noncoding transcripts regulate gene expression various ways affect malignant phenotypes cells. At present, biological function underlying ncRNAs have partially elucidated. Herein, we summarize current knowledge central network ferroptosis, with focus functions ferroptosis. The clinical prospects ferroptosis-related diagnosis, prognosis anticancer therapies also discussed. Elucidating along assessing significance ncRNAs, provides new perspectives for understanding biology treatment approaches, may benefit numerous patients future.

Language: Английский

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The functions and mechanisms of long non-coding RNA in colorectal cancer

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 4, 2024

CRC poses a significant challenge in the global health domain, with high number of deaths attributed to this disease annually. If is detected only its advanced stages, difficulty treatment increases significantly. Therefore, biomarkers for early detection play crucial role improving patient outcomes and increasing survival rates. The development reliable biomarker particularly important timely diagnosis treatment. However, current methods detection, such as endoscopic examination, blood, stool tests, have certain limitations often detect cases late stages. To overcome these constraints, researchers turned their attention molecular biomarkers, which are considered promising approach detection. Non-invasive using mRNA, circulating cell-free DNA, microRNA, LncRNA, proteins can provide more diagnostic information. These be found tissue, stool, volatile organic compounds. Identifying sensitivity specificity safe, economic, easily measurable remains researchers.

Language: Английский

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Advances in understanding the role of lncRNA in ferroptosis

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17933 - e17933

Published: Aug. 26, 2024

LncRNA is a type of transcript with length exceeding 200 nucleotides, which was once considered junk no biological function during the transcription process. In recent years, lncRNA has been shown to act as an important regulatory factor at multiple levels gene expression, affecting various programmed cell death modes including ferroptosis. Ferroptosis, new form death, characterized by deficiency cysteine or inactivation glutathione peroxidase, leading depletion glutathione, aggregation iron ions, and lipid peroxidation. These processes are influenced many physiological processes, such Nrf2 pathway, autophagy, p53 pathway so on. An increasing number studies have that can block expression specific molecules through decoy effect, guide proteins function, promote interactions between scaffolds. action regulate key factors in metabolism, antioxidant metabolism epigenetic genetic regulation, thereby regulating process this review, we snapshotted mechanism ferroptosis example, emphasizing regulation on these pathways, helping fully understand evolution fate.

Language: Английский

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