Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe? DOI Open Access
Aliea M. Jalali, Keith Mitchell, Christian Pompoco

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13689 - 13689

Published: Dec. 21, 2024

Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression therapy. NLRP3-mediated immune response pyroptosis could be helpful or harmful cancer, depend on nature tumor microenvironment. The activation increase surveillance efficacy immunotherapy. It can lead to removal cells by recruitment phagocytic macrophages, T-lymphocytes, other site. On hand, harmful, as chronic inflammation driven supports creating an environment that facilitates cell proliferation, migration, invasion, metastasis. release pro-inflammatory cytokines such IL-1β IL-18 promote growth angiogenesis, while sustained may suppression, hindering effective anti-tumor responses. In this review article, we discuss role inflammasome-mediated pathophysiology types; understanding is essential for development innovative therapeutic strategies spread.

Language: Английский

Inhibitors of inflammasome (NLRP3) signaling pathway as promising therapeutic candidates for oral cancer DOI
Shreya Agrawal,

Saran A. Narang,

Yadvendra Shahi

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130800 - 130800

Published: April 1, 2025

Language: Английский

Citations

0
Impact of oral flora in tongue coating and saliva on oral cancer risk and the regulatory role of Interleukin-8 DOI
Xuemin Wang,

Xiaona Song,

Jiping Gao

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 185, P. 156821 - 156821

Published: Dec. 3, 2024

Language: Английский

Citations

1
Therapeutic Significance of NLRP3 Inflammasome in Cancer: Friend or Foe? DOI Open Access
Aliea M. Jalali, Keith Mitchell, Christian Pompoco

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13689 - 13689

Published: Dec. 21, 2024

Besides various infectious and inflammatory complications, recent studies also indicated the significance of NLRP3 inflammasome in cancer progression therapy. NLRP3-mediated immune response pyroptosis could be helpful or harmful cancer, depend on nature tumor microenvironment. The activation increase surveillance efficacy immunotherapy. It can lead to removal cells by recruitment phagocytic macrophages, T-lymphocytes, other site. On hand, harmful, as chronic inflammation driven supports creating an environment that facilitates cell proliferation, migration, invasion, metastasis. release pro-inflammatory cytokines such IL-1β IL-18 promote growth angiogenesis, while sustained may suppression, hindering effective anti-tumor responses. In this review article, we discuss role inflammasome-mediated pathophysiology types; understanding is essential for development innovative therapeutic strategies spread.

Language: Английский

Citations

0