Neuropsychiatric Disease and Treatment,
Journal Year:
2023,
Volume and Issue:
Volume 19, P. 811 - 828
Published: April 1, 2023
Abstract:
A
healthy
stress
response
is
critical
for
good
mental
and
overall
health
promotes
neuronal
growth
adaptation,
but
the
intricately
balanced
biological
mechanisms
that
facilitate
a
can
also
result
in
predisposition
to
disease
when
equilibrium
disrupted.
The
hypothalamic-pituitary-adrenal
(HPA)
axis
neuroendocrine
system
plays
role
body's
adaptation
stress,
vasopressinergic
regulation
of
HPA
maintaining
responsiveness
during
chronic
stress.
However,
exposure
repeated
or
excessive
physical
emotional
trauma
shift
"new
normal"
underpinned
by
enduring
changes
function.
Exposure
early
life
due
adverse
childhood
experiences
lead
lasting
neurobiological
changes,
including
impairment
patients
with
depression
considered
among
most
reliable
findings
psychiatry,
has
been
shown
play
major
pathogenesis
onset
other
neuropsychiatric
disorders.
Modulating
activity,
example
via
targeted
antagonism
vasopressin
V
1b
receptor,
promising
approach
disorders
associated
impairment.
Despite
favorable
preclinical
indications
animal
models,
demonstration
clinical
efficacy
treatment
depressive
targeting
dysfunction
challenging,
possibly
heterogeneity
syndromal
nature
Measures
function,
such
as
elevated
cortisol
levels,
may
be
useful
biomarkers
identifying
who
benefit
from
treatments
modulate
activity.
Utilizing
identify
subsets
impaired
function
next
step
fine-tuning
activity
receptor.
Keywords:
allostatic
overload,
cortisol,
axis,
disorder,
Gerontology and Geriatric Medicine,
Journal Year:
2023,
Volume and Issue:
9
Published: Jan. 1, 2023
More
than
16
million
Americans
provide
unpaid
care
for
someone
with
Alzheimer's
disease
and
related
dementias
(ADRD).
During
the
COVID-19
pandemic,
caregivers
experienced
increased
chronic
severe
stress
from
widespread
closures
social
distancing.
We
conducted
eight
surveys
March
2020
to
2021
among
a
cohort
of
over
10,000
individuals.
Cross-sectional
analysis
was
investigate
frequency
ratios
groups
reporting
across
surveys.
A
longitudinal
also
performed
1,030
participants
who
took
more
one
survey.
found
growing
crisis
dementia
caregivers:
By
Survey
8,
current
reported
2.9
times
higher
levels
comparator
group.
that
time,
64%
having
multiple
symptoms
typically
in
people
experiencing
stress.
Both
analyses
stressors
time
were
associated
certain
caregiver
groups.
Our
findings
underscore
urgent
need
public
policy
initiatives
supportive
community
infrastructure
support
ADRD
caregivers.
European journal of psychotraumatology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 22, 2024
Background:
The
COVID-19
pandemic
caused
multiple
stressors
that
may
lead
to
symptoms
of
adjustment
disorder.Objective:
We
longitudinally
examined
relationships
between
risk
and
protective
factors,
pandemic-related
disorder
during
the
pandemic,
as
well
whether
these
differed
by
time
assessment.Method:
European
Society
for
Traumatic
Stress
Studies
(ESTSS)
ADJUST
Study
included
N
=
15,169
participants
aged
18
years
above.
Participants
from
11
countries
were
recruited
screened
three
times
at
6-month
intervals
June
2020
January
2022.
Associations
factors
(e.g.
gender),
fear
infection),
(AjD,
ADNM-8)
their
interaction
with
assessment
using
mixed
linear
regression.Results:
following
predictors
significantly
associated
higher
AjD
symptom
levels:
female
or
diverse
gender;
older
age;
news
consumption
>30
min
a
day;
current
previous
mental
health
disorder;
trauma
exposure
before
pandemic;
good,
satisfactory
poor
status
(vs.
very
good);
burden
related
governmental
crisis
management
communication;
infection;
restricted
social
contact;
work-related
problems;
activity;
difficult
housing
conditions.
lower
self-employment
retirement;
working
in
healthcare;
face-to-face
contact
≥
once
week
loved
ones
friends.
effects
on
course
pandemic:
management;
income
reduction;
exposure.Conclusions:
identified
predicting
levels
different
stages
pandemic.
For
some
predictors,
change
Sexuality Research and Social Policy,
Journal Year:
2024,
Volume and Issue:
21(3), P. 1086 - 1099
Published: May 9, 2024
Abstract
Introduction
The
acute
phase
of
the
COVID-19
pandemic
impacted
sexual
function
and
mental
health
healthcare
workers
worldwide.
However,
extent
to
which
health,
including
its
relational
dimension,
was
affected
among
different
services
protective
coping
strategies
employed
at
that
time
is
currently
unclear.
present
study
aimed
investigate
these
two
issues,
exploring
for
first
role
meaning-centered
on
health.
Method
sample
consisted
109
divided
into
groups:
a
high-exposure
group
(Intensive
Care
Unit
service,
63
participants)
low-exposure
(gynecology,
obstetrics,
pediatrics
services,
46
participants).
One
year
after
onset
pandemic,
participants
completed
an
online
survey
comprised
sociodemographic
exposure
variables,
Depression
Anxiety
Stress
Scale,
New
Sexual
Satisfaction
Scale-Short
Form,
Meaning-Centered
Coping
Scale.
Results
(1)
High-exposure
reported
more
anxiety
depressive
symptoms,
(2)
anxiety,
depression
stress
were
associated
with
decreased
(3)
higher
decrease
in
their
(4)
levels
coping,
(5)
predicted
both
groups.
Policy
Implications
Various
pose
distinct
risks
regarding
detrimental
effects
collective
crises
therefore
they
should
be
differently
treated.
promotion
sensible
policy
improve
preparedness
contexts,
especially
vulnerable
subpopulations.
Healthcare,
Journal Year:
2024,
Volume and Issue:
12(22), P. 2277 - 2277
Published: Nov. 14, 2024
Background:
Health
professionals
are
at
high
risk
of
poor
mental
health
and
well-being.
Faced
with
this
challenge,
healthcare
organizations
must
be
healthy
safe
work
environments.
Objectives:
This
study
aims
to
take
an
in-depth,
systemic
look
whether
workplaces.
Methods:
The
involved
2190
participants
aged
between
19
71
(M
=
44.73,
SD
10.29)
data
were
collected
in
12
public
hospitals
November
2021
December
2023.
used
the
Ecosystems
Healthy
Workplaces
instrument,
which
consists
a
total
62
items
organized
into
nine
dimensions
based
on
model
proposed
by
World
Organization.
Results:
Most
revealed
moderate
terms
they
environments,
while
dimension
that
was
related
psychosocial
risks
relation
well-being
health.
A
87%
reported
least
one
symptom
burnout
61.4%
having
all
three
symptoms
burnout.
Additionally,
25.4%
been
victims
harassment
work.
When
comparing
groups,
we
identified
higher
groups
namely
women,
generation
Z
X
professionals,
doctors
(compared
different
professional
under
analysis
such
as
nurses,
operational
assistants,
psychologists,
administrators,
senior
technicians,
managers),
chronic
illnesses,
those
who
Conclusions:
We
conclude
environment
understood
ecologically,
analyzing
systems
their
relationships.
makes
it
possible
identify
priority
factors
for
intervention.
Neuropsychiatric Disease and Treatment,
Journal Year:
2023,
Volume and Issue:
Volume 19, P. 811 - 828
Published: April 1, 2023
Abstract:
A
healthy
stress
response
is
critical
for
good
mental
and
overall
health
promotes
neuronal
growth
adaptation,
but
the
intricately
balanced
biological
mechanisms
that
facilitate
a
can
also
result
in
predisposition
to
disease
when
equilibrium
disrupted.
The
hypothalamic-pituitary-adrenal
(HPA)
axis
neuroendocrine
system
plays
role
body's
adaptation
stress,
vasopressinergic
regulation
of
HPA
maintaining
responsiveness
during
chronic
stress.
However,
exposure
repeated
or
excessive
physical
emotional
trauma
shift
"new
normal"
underpinned
by
enduring
changes
function.
Exposure
early
life
due
adverse
childhood
experiences
lead
lasting
neurobiological
changes,
including
impairment
patients
with
depression
considered
among
most
reliable
findings
psychiatry,
has
been
shown
play
major
pathogenesis
onset
other
neuropsychiatric
disorders.
Modulating
activity,
example
via
targeted
antagonism
vasopressin
V
1b
receptor,
promising
approach
disorders
associated
impairment.
Despite
favorable
preclinical
indications
animal
models,
demonstration
clinical
efficacy
treatment
depressive
targeting
dysfunction
challenging,
possibly
heterogeneity
syndromal
nature
Measures
function,
such
as
elevated
cortisol
levels,
may
be
useful
biomarkers
identifying
who
benefit
from
treatments
modulate
activity.
Utilizing
identify
subsets
impaired
function
next
step
fine-tuning
activity
receptor.
Keywords:
allostatic
overload,
cortisol,
axis,
disorder,