Targeting the Arginine Vasopressin V1b Receptor System and Stress Response in Depression and Other Neuropsychiatric Disorders DOI Creative Commons

Stephen Kanes,

Lara Dennie,

Philip Perera

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 811 - 828

Published: April 1, 2023

Abstract: A healthy stress response is critical for good mental and overall health promotes neuronal growth adaptation, but the intricately balanced biological mechanisms that facilitate a can also result in predisposition to disease when equilibrium disrupted. The hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system plays role body's adaptation stress, vasopressinergic regulation of HPA maintaining responsiveness during chronic stress. However, exposure repeated or excessive physical emotional trauma shift "new normal" underpinned by enduring changes function. Exposure early life due adverse childhood experiences lead lasting neurobiological changes, including impairment patients with depression considered among most reliable findings psychiatry, has been shown play major pathogenesis onset other neuropsychiatric disorders. Modulating activity, example via targeted antagonism vasopressin V 1b receptor, promising approach disorders associated impairment. Despite favorable preclinical indications animal models, demonstration clinical efficacy treatment depressive targeting dysfunction challenging, possibly heterogeneity syndromal nature Measures function, such as elevated cortisol levels, may be useful biomarkers identifying who benefit from treatments modulate activity. Utilizing identify subsets impaired function next step fine-tuning activity receptor. Keywords: allostatic overload, cortisol, axis, disorder,

Language: Английский

Caring for Dementia Caregivers: Understanding Caregiver Stress During the COVID-19 Pandemic DOI Creative Commons
Lee Lancashire, Virginia Biggar,

Meryl Comer

et al.

Gerontology and Geriatric Medicine, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 1, 2023

More than 16 million Americans provide unpaid care for someone with Alzheimer's disease and related dementias (ADRD). During the COVID-19 pandemic, caregivers experienced increased chronic severe stress from widespread closures social distancing. We conducted eight surveys March 2020 to 2021 among a cohort of over 10,000 individuals. Cross-sectional analysis was investigate frequency ratios groups reporting across surveys. A longitudinal also performed 1,030 participants who took more one survey. found growing crisis dementia caregivers: By Survey 8, current reported 2.9 times higher levels comparator group. that time, 64% having multiple symptoms typically in people experiencing stress. Both analyses stressors time were associated certain caregiver groups. Our findings underscore urgent need public policy initiatives supportive community infrastructure support ADRD caregivers.

Language: Английский

Citations

7

A longitudinal study of risk and protective factors for symptoms of adjustment disorder during the COVID-19 pandemic DOI Creative Commons
Annett Lotzin, Katharina Stahlmann,

Elena Acquarini

et al.

European journal of psychotraumatology, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 22, 2024

Background: The COVID-19 pandemic caused multiple stressors that may lead to symptoms of adjustment disorder.Objective: We longitudinally examined relationships between risk and protective factors, pandemic-related disorder during the pandemic, as well whether these differed by time assessment.Method: European Society for Traumatic Stress Studies (ESTSS) ADJUST Study included N = 15,169 participants aged 18 years above. Participants from 11 countries were recruited screened three times at 6-month intervals June 2020 January 2022. Associations factors (e.g. gender), fear infection), (AjD, ADNM-8) their interaction with assessment using mixed linear regression.Results: following predictors significantly associated higher AjD symptom levels: female or diverse gender; older age; news consumption >30 min a day; current previous mental health disorder; trauma exposure before pandemic; good, satisfactory poor status (vs. very good); burden related governmental crisis management communication; infection; restricted social contact; work-related problems; activity; difficult housing conditions. lower self-employment retirement; working in healthcare; face-to-face contact ≥ once week loved ones friends. effects on course pandemic: management; income reduction; exposure.Conclusions: identified predicting levels different stages pandemic. For some predictors, change

Language: Английский

Citations

2

Sexual and Mental Health in Healthcare Workers during the COVID-19 Outbreak: Exploring the Role of Meaning-Centered Coping DOI Creative Commons
José Antonio Pérez‐Escobar, David F. Carreno,

Rosalía Pérez-Escobar

et al.

Sexuality Research and Social Policy, Journal Year: 2024, Volume and Issue: 21(3), P. 1086 - 1099

Published: May 9, 2024

Abstract Introduction The acute phase of the COVID-19 pandemic impacted sexual function and mental health healthcare workers worldwide. However, extent to which health, including its relational dimension, was affected among different services protective coping strategies employed at that time is currently unclear. present study aimed investigate these two issues, exploring for first role meaning-centered on health. Method sample consisted 109 divided into groups: a high-exposure group (Intensive Care Unit service, 63 participants) low-exposure (gynecology, obstetrics, pediatrics services, 46 participants). One year after onset pandemic, participants completed an online survey comprised sociodemographic exposure variables, Depression Anxiety Stress Scale, New Sexual Satisfaction Scale-Short Form, Meaning-Centered Coping Scale. Results (1) High-exposure reported more anxiety depressive symptoms, (2) anxiety, depression stress were associated with decreased (3) higher decrease in their (4) levels coping, (5) predicted both groups. Policy Implications Various pose distinct risks regarding detrimental effects collective crises therefore they should be differently treated. promotion sensible policy improve preparedness contexts, especially vulnerable subpopulations.

Language: Английский

Citations

2

Are Healthcare Organizations Healthy Work Ecosystems? Health and Well-Being of Health Professionals DOI Open Access
Tânia Gaspar, Bárbara Sousa, Elisabete Alves

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(22), P. 2277 - 2277

Published: Nov. 14, 2024

Background: Health professionals are at high risk of poor mental health and well-being. Faced with this challenge, healthcare organizations must be healthy safe work environments. Objectives: This study aims to take an in-depth, systemic look whether workplaces. Methods: The involved 2190 participants aged between 19 71 (M = 44.73, SD 10.29) data were collected in 12 public hospitals November 2021 December 2023. used the Ecosystems Healthy Workplaces instrument, which consists a total 62 items organized into nine dimensions based on model proposed by World Organization. Results: Most revealed moderate terms they environments, while dimension that was related psychosocial risks relation well-being health. A 87% reported least one symptom burnout 61.4% having all three symptoms burnout. Additionally, 25.4% been victims harassment work. When comparing groups, we identified higher groups namely women, generation Z X professionals, doctors (compared different professional under analysis such as nurses, operational assistants, psychologists, administrators, senior technicians, managers), chronic illnesses, those who Conclusions: We conclude environment understood ecologically, analyzing systems their relationships. makes it possible identify priority factors for intervention.

Language: Английский

Citations

2

Targeting the Arginine Vasopressin V1b Receptor System and Stress Response in Depression and Other Neuropsychiatric Disorders DOI Creative Commons

Stephen Kanes,

Lara Dennie,

Philip Perera

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 811 - 828

Published: April 1, 2023

Abstract: A healthy stress response is critical for good mental and overall health promotes neuronal growth adaptation, but the intricately balanced biological mechanisms that facilitate a can also result in predisposition to disease when equilibrium disrupted. The hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system plays role body's adaptation stress, vasopressinergic regulation of HPA maintaining responsiveness during chronic stress. However, exposure repeated or excessive physical emotional trauma shift "new normal" underpinned by enduring changes function. Exposure early life due adverse childhood experiences lead lasting neurobiological changes, including impairment patients with depression considered among most reliable findings psychiatry, has been shown play major pathogenesis onset other neuropsychiatric disorders. Modulating activity, example via targeted antagonism vasopressin V 1b receptor, promising approach disorders associated impairment. Despite favorable preclinical indications animal models, demonstration clinical efficacy treatment depressive targeting dysfunction challenging, possibly heterogeneity syndromal nature Measures function, such as elevated cortisol levels, may be useful biomarkers identifying who benefit from treatments modulate activity. Utilizing identify subsets impaired function next step fine-tuning activity receptor. Keywords: allostatic overload, cortisol, axis, disorder,

Language: Английский

Citations

6