The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-İnduced Testicular Tissue Damage DOI Creative Commons
Tuba Yalçın, Sercan Kaya, Akın Yiğin

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(8), P. 2433 - 2446

Published: April 24, 2024

Abstract One of the adverse effects antineoplastic drug cisplatin (CS) is damage to testicular tissue. This study aimed examine potential therapeutic effect thymoquinone (TQ), a strong antioxidant, against caused by CS. In experiment, 28 rats were used, and randomly divided into four groups: control ( n = 7), CS + TQ 7). The experiment was called off after all treatments finished on day 15. Blood serum tissues utilized for biochemical, histological, immunohistochemical, mRNA expression, gene protein investigations. testosterone level decreased oxidative stress, histopathological damage, dysregulation in mitochondrial dynamics, inflammation apoptotic cells increased tissue due administration. supplementation showed anti-inflammatory, anti-apoptotic response CS-induced damage. addition, contributed reduction toxic regulating TNF-α/OTULIN/NF-κB pathway. may be strategy axis, inhibiting inflammation, apoptosis.

Language: Английский

Linalool may have a therapeutic effect on cadmium-induced nephrotoxicity by regulating NF-κB/TNF and GRP78/CHOP signaling pathways DOI
Sercan Kaya, Tuba Yalçın

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127510 - 127510

Published: Aug. 26, 2024

Language: Английский

Citations

6
Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model DOI
Tuba Yalçın, Sercan Kaya, Tuncay Kuloğlu

et al.

Toxicology Mechanisms and Methods, Journal Year: 2023, Volume and Issue: 34(1), P. 98 - 108

Published: Oct. 9, 2023

AbstractOne of the most important side effects Doxorubicin (DOX), a chemotherapeutic agent, is nephrotoxicity. The purpose this study to determine whether different doses natural polyphenol Resveratrol (RSV) show antioxidative, anti-inflammatory or antiapoptotic in kidney tissue DOX-induced nephrotoxicity and detect how nephrin OTULIN levels are affected process. A total six equal groups made up 42 Sprague-Dawley rats utilized (n = 7) were randomly assigned. Except for control group (no treatment), all treatments given intraperitoneally DOX (15 mg/kg), + RSV I mg/kg DOX+ 1 mg/kg/day RSV), II 5 groups. Kidney tissues taken from sacrificed on fifteenth day analyzed biochemically, histologically immunohistochemically. Accordingly, it was determined that decreased Furthermore, caused oxidative stress, inflammation, apoptosis, as well histopathological changes tissue. However, observed regulated by application. demonstrated have antioxidant, anti-apoptotic properties dose-dependent may exert nephroprotective modulating altered levels.Keywords: OTULINnephrindoxorubicinresveratrolnephrotoxicity ContributionsIdea/Concept: TY, SK, TK; Design: SK; Data Collection/Processing: Analysis/Interpretation: TK, TY; Literature Review: Drafting/Writing: Critical TK.Disclosure statementNo potential conflict interest reported author(s).Data availability statementThe data will be available request.Additional informationFundingThe author(s) there no funding associated with work featured article.

Language: Английский

Citations

10
Therapeutic potential of the linalool against cadmium-induced testicular tissue damage DOI
Tuba Yalçın, Sercan Kaya

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 84, P. 127455 - 127455

Published: April 15, 2024

Language: Английский

Citations

1
OTULIN Can Improve Spinal Cord Injury by the NF-κB and Wnt/β-Catenin Signaling Pathways DOI
Qianhui Wang,

Lvxia Wang,

Benson O. A. Botchway

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Language: Английский

Citations

1
Potential therapeutic effect of Thymoquinone on Cisplatin-induced hepatotoxicity in rats DOI Open Access
Sercan Kaya, Tuba Yalçın

Eurasian journal of veterinary sciences, Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Aim: Cisplatin (CIS), an antineoplastic agent, shows serious side effects such as hepatotoxicity. Thymoquinone (ThQ) is a powerful anti-oxidant with many beneficial anti-inflammatory, anti-tumoral. The aim of this study was to investigate whether ThQ treatment has hepatoprotective effect in CIS-induced hepatotoxicity model rats and also determine how CIS and/or treatments affect OTULIN levels, one the deubiquitinases, liver tissue. Materials Methods: 28 used control (application not done), (7 mg/kg CIS, first day experiment, intraperitoneal), CIS+ThQ intraperitoneal + 10 mg/kg/day ThQ, oral gavage) (10 were divided into four equal groups (n=7). experiment terminated upon completion all applications (day 15). and\or apps on tissues examined biochemically, histopathologically immunohistochemically. Results: application increased enzyme histopathological changes, inflammation, oxidative stress apoptosis tissue caused decrease level. However, administration showed positive regulatory changes Conclusion: supplementation against damage.

Language: Английский

Citations

0
The Effect of Thymoquinone on the TNF-α/OTULIN/NF-κB Axis Against Cisplatin-İnduced Testicular Tissue Damage DOI Creative Commons
Tuba Yalçın, Sercan Kaya, Akın Yiğin

et al.

Reproductive Sciences, Journal Year: 2024, Volume and Issue: 31(8), P. 2433 - 2446

Published: April 24, 2024

Abstract One of the adverse effects antineoplastic drug cisplatin (CS) is damage to testicular tissue. This study aimed examine potential therapeutic effect thymoquinone (TQ), a strong antioxidant, against caused by CS. In experiment, 28 rats were used, and randomly divided into four groups: control ( n = 7), CS + TQ 7). The experiment was called off after all treatments finished on day 15. Blood serum tissues utilized for biochemical, histological, immunohistochemical, mRNA expression, gene protein investigations. testosterone level decreased oxidative stress, histopathological damage, dysregulation in mitochondrial dynamics, inflammation apoptotic cells increased tissue due administration. supplementation showed anti-inflammatory, anti-apoptotic response CS-induced damage. addition, contributed reduction toxic regulating TNF-α/OTULIN/NF-κB pathway. may be strategy axis, inhibiting inflammation, apoptosis.

Language: Английский

Citations

0