Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 466090 - 466090
Published: June 1, 2025
Language: Английский
Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 466090 - 466090
Published: June 1, 2025
Language: Английский
Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(3)
Published: March 1, 2025
Inertial microfluidic technology has emerged as a highly promising approach for the separation of particles/cells, characterized by high throughput and label-free features. This study presents novel inertial chip design that enables continuous target particles at low Reynolds numbers (Re ≤ 36). To enhance its sorting performance, influences = 3.7–60), particle sizes (d 10 20 μm), outlet flow rates on efficiency purity are further examined, phase diagram optimal working conditions is obtained. The evolution field structure within comprehensively analyzed, which can be divided into three distinct regions, namely, main flow, sheath vortex. mechanism migration behavior across curved streamlines explored. device achieve maximum 94% large with fivefold increase in enrichment concentration, 31.3-fold purity, removal small reaching 97.1%. results demonstrate this facilitate direct larger based their size, presenting numerous advantages, such short microchannel length, number, minimal cell damage, ease operation. Hence, method represents an easy-to-use straightforward techniques anticipated to have practical application rare circulating tumor cells from complex solutions.
Language: Английский
Citations
0Physica Scripta, Journal Year: 2025, Volume and Issue: 100(4), P. 045004 - 045004
Published: March 5, 2025
Abstract This study presents a method for separating and recovering micron-sized objects using microfluidic devices, belonging to the passive group that utilises flow. The proposed in this submillimetre-scale structures within device, thereby eliminating need high-precision microfabrication. Furthermore, use of slow flow conditions distinguishes approach from many previous studies. objective research was successfully separate particles with diameters ranging 1 20 μm. By optimising rate conditions, 100% separation achieved 6.00 10.0 μm, 96.9% diameter 20.0 These results compare favourably with, or exceed, those reported studies where methods were used cell separation. Moreover, technique effectively avoids issues viscosity clogging are inherent based on conventional pillar filter structures. selecting optimal rate, we also able isolate 1.00 Thus, could serve as technically viable alternative centrifugation, which is commonly pre-processing step blood tests. well-suited applications such aforementioned test, larger than specified size trapped suspension containing multiple particle sizes smaller recovered outlet well.
Language: Английский
Citations
0Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 466090 - 466090
Published: June 1, 2025
Language: Английский
Citations
0