Continuous and straightforward sorting of particles in microcavities with side outlets using inertial microfluidics
Physics of Fluids,
Journal Year:
2025,
Volume and Issue:
37(3)
Published: March 1, 2025
Inertial
microfluidic
technology
has
emerged
as
a
highly
promising
approach
for
the
separation
of
particles/cells,
characterized
by
high
throughput
and
label-free
features.
This
study
presents
novel
inertial
chip
design
that
enables
continuous
target
particles
at
low
Reynolds
numbers
(Re
≤
36).
To
enhance
its
sorting
performance,
influences
=
3.7–60),
particle
sizes
(d
10
20
μm),
outlet
flow
rates
on
efficiency
purity
are
further
examined,
phase
diagram
optimal
working
conditions
is
obtained.
The
evolution
field
structure
within
comprehensively
analyzed,
which
can
be
divided
into
three
distinct
regions,
namely,
main
flow,
sheath
vortex.
mechanism
migration
behavior
across
curved
streamlines
explored.
device
achieve
maximum
94%
large
with
fivefold
increase
in
enrichment
concentration,
31.3-fold
purity,
removal
small
reaching
97.1%.
results
demonstrate
this
facilitate
direct
larger
based
their
size,
presenting
numerous
advantages,
such
short
microchannel
length,
number,
minimal
cell
damage,
ease
operation.
Hence,
method
represents
an
easy-to-use
straightforward
techniques
anticipated
to
have
practical
application
rare
circulating
tumor
cells
from
complex
solutions.
Language: Английский
Method for separating micron-sized particles using submillimetre-scale structures
Takahiro Kobayashi,
No information about this author
Shuichi Murakami,
No information about this author
Mitsuhiro Horade
No information about this author
et al.
Physica Scripta,
Journal Year:
2025,
Volume and Issue:
100(4), P. 045004 - 045004
Published: March 5, 2025
Abstract
This
study
presents
a
method
for
separating
and
recovering
micron-sized
objects
using
microfluidic
devices,
belonging
to
the
passive
group
that
utilises
flow.
The
proposed
in
this
submillimetre-scale
structures
within
device,
thereby
eliminating
need
high-precision
microfabrication.
Furthermore,
use
of
slow
flow
conditions
distinguishes
approach
from
many
previous
studies.
objective
research
was
successfully
separate
particles
with
diameters
ranging
1
20
μm.
By
optimising
rate
conditions,
100%
separation
achieved
6.00
10.0
μm,
96.9%
diameter
20.0
These
results
compare
favourably
with,
or
exceed,
those
reported
studies
where
methods
were
used
cell
separation.
Moreover,
technique
effectively
avoids
issues
viscosity
clogging
are
inherent
based
on
conventional
pillar
filter
structures.
selecting
optimal
rate,
we
also
able
isolate
1.00
Thus,
could
serve
as
technically
viable
alternative
centrifugation,
which
is
commonly
pre-processing
step
blood
tests.
well-suited
applications
such
aforementioned
test,
larger
than
specified
size
trapped
suspension
containing
multiple
particle
sizes
smaller
recovered
outlet
well.
Language: Английский
3D Finite Element Simulation of Continuous System for Cells and Bacteria Separation Using a Combination of I-Shaped Deterministic Lateral Displacement Arrays and Acoustophoresis Based on Tilted-Angle Standing Surface Acoustic Wave
Journal of Chromatography A,
Journal Year:
2025,
Volume and Issue:
unknown, P. 466090 - 466090
Published: June 1, 2025
Language: Английский