3D Finite Element Simulation of Continuous System for Cells and Bacteria Separation Using a Combination of I-Shaped Deterministic Lateral Displacement Arrays and Acoustophoresis Based on Tilted-Angle Standing Surface Acoustic Wave DOI
Mehran Ebrahimi, Mohsen Rabbani

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 466090 - 466090

Published: June 1, 2025

Language: Английский

Continuous and straightforward sorting of particles in microcavities with side outlets using inertial microfluidics DOI
Feng Shen, Jie Zhang, Chenchen Zhang

et al.

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(3)

Published: March 1, 2025

Inertial microfluidic technology has emerged as a highly promising approach for the separation of particles/cells, characterized by high throughput and label-free features. This study presents novel inertial chip design that enables continuous target particles at low Reynolds numbers (Re ≤ 36). To enhance its sorting performance, influences = 3.7–60), particle sizes (d 10 20 μm), outlet flow rates on efficiency purity are further examined, phase diagram optimal working conditions is obtained. The evolution field structure within comprehensively analyzed, which can be divided into three distinct regions, namely, main flow, sheath vortex. mechanism migration behavior across curved streamlines explored. device achieve maximum 94% large with fivefold increase in enrichment concentration, 31.3-fold purity, removal small reaching 97.1%. results demonstrate this facilitate direct larger based their size, presenting numerous advantages, such short microchannel length, number, minimal cell damage, ease operation. Hence, method represents an easy-to-use straightforward techniques anticipated to have practical application rare circulating tumor cells from complex solutions.

Language: Английский

Citations

0

Method for separating micron-sized particles using submillimetre-scale structures DOI

Takahiro Kobayashi,

Shuichi Murakami,

Mitsuhiro Horade

et al.

Physica Scripta, Journal Year: 2025, Volume and Issue: 100(4), P. 045004 - 045004

Published: March 5, 2025

Abstract This study presents a method for separating and recovering micron-sized objects using microfluidic devices, belonging to the passive group that utilises flow. The proposed in this submillimetre-scale structures within device, thereby eliminating need high-precision microfabrication. Furthermore, use of slow flow conditions distinguishes approach from many previous studies. objective research was successfully separate particles with diameters ranging 1 20 μm. By optimising rate conditions, 100% separation achieved 6.00 10.0 μm, 96.9% diameter 20.0 These results compare favourably with, or exceed, those reported studies where methods were used cell separation. Moreover, technique effectively avoids issues viscosity clogging are inherent based on conventional pillar filter structures. selecting optimal rate, we also able isolate 1.00 Thus, could serve as technically viable alternative centrifugation, which is commonly pre-processing step blood tests. well-suited applications such aforementioned test, larger than specified size trapped suspension containing multiple particle sizes smaller recovered outlet well.

Language: Английский

Citations

0

3D Finite Element Simulation of Continuous System for Cells and Bacteria Separation Using a Combination of I-Shaped Deterministic Lateral Displacement Arrays and Acoustophoresis Based on Tilted-Angle Standing Surface Acoustic Wave DOI
Mehran Ebrahimi, Mohsen Rabbani

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: unknown, P. 466090 - 466090

Published: June 1, 2025

Language: Английский

Citations

0