Effect of linex treatment on IFN-γ and IL-4 in mice infected with Trichinella DOI Creative Commons
Shimaa Atta,

Zeinab Fahmy,

Eman A. H. Selim

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 28, 2024

Abstract Trichinellosis is a zoonotic, foodborne parasitic infection causing muscle damage. This study investigated the potential therapeutic effects of commercially available probiotic treatment Linex, both alone and in combination with Albendazole (ALB), on intestinal muscular stages Trichinella spiralis mice, assessing outcomes through parasitological, immunological, histopathological measures. first to demonstrate synergistic effect combining Linex for trichinellosis treatment. By enhancing parasitological immunological outcomes, this combined therapy not only significantly reduces parasite burden but also modulates immune response, shifting it toward protective Th1 profile. In terms, highest adult larval count reduction was observed (100%, 97.7%) respectively. Lesser percentage were recorded (43.2%, 88.4%) Histopathologically there amelioration inflammatory cellular infiltration all treated groups best results Immunologically, serum IFN-γ levels increased treatment, while IL-4 IL-13 level decreased To conclude; mice infected T. spirals could ameliorate improve response.

Language: Английский

Evaluation of the probiotic, anti-bacterial, anti-biofilm, and safety properties of Lacticaseibacillus paracasei B31-2 DOI Creative Commons
Behrooz Alizadeh Behbahani, Hossein Jooyandeh, Morteza Taki

et al.

LWT, Journal Year: 2024, Volume and Issue: 207, P. 116676 - 116676

Published: Aug. 26, 2024

Language: Английский

Citations

14
Changes in Hormonal Profile and Body Mass Index in Women with Polycystic Ovary Syndrome After Probiotic Intake: A 12-Week Placebo-Controlled and Randomized Clinical Study DOI Open Access
Iwona Szydłowska, Jolanta Nawrocka-Rutkowska, Amalia Gorzko

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 405 - 405

Published: Jan. 23, 2025

Introduction: The beneficial effect of probiotics on the improvement carbohydrate and lipid metabolism, as well body mass index (BMI), has been demonstrated in various patient groups. We aimed to investigate a multi-strain probiotic hormonal balance women with PCOS. Ethical approval was obtained from Bioethical Committee. Methods: study designed 12-week, randomized, double-blind, placebo-controlled clinical study. SanProbi® Barrier capsules, which contain unique composition nine bacteria strains (Lactobacillus Biffidobacterium), were used mean age participants 28.42 ± 5.62 years. A total 50 PCOS, diagnosed based Rotterdam ESHRE criteria, included Among them, 25 randomized placebo group, group. Results: comparison changes individual hormone levels between groups confirmed statistically significant differences for TSH, androstenedione, SHBG, BMI. In case LH, statistical significance difference delta change group use one-tailed test. Conclusions: Probiotic supplementation may serve an alternative supporting treatment, especially phenotype high FAI index. therapy is also effective reducing BMI overweight PCOS

Language: Английский

Citations

1
Bibliometric Mapping on the Probiotic Trends in Managing Aquaculture Pathogens. DOI
Muhamad Firdaus Syahmi Sam-on, Shuhaimi Mustafa, Amalia Mohd Hashim

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106372 - 106372

Published: March 1, 2025

Language: Английский

Citations

1
Antimicrobial activity of Lactobacillus casei on Staphylococcus pseudintermedius isolates DOI Open Access
Danielle Cavalcanti de Carvalho Diniz, Márcio Garcia Ribeiro, Gabriele Silva Dias

et al.

Veterinary Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Background Antimicrobial resistance is increasing each year. For example, in 2019 it was directly responsible for an estimated >1 million deaths. Additionally, the development of new drugs much slower, generating enormous concerns about responses to infection future health scenario. Therefore, probiotics have emerged as alternative antibiotics. Objectives This study aimed isolate and identify a Lactobacillus casei from healthy canine skin investigate its antimicrobial effect on isolates Staphylococcus pseudintermedius originating dogs with pyoderma. Materials Methods L. isolated samples collected sterile cotton swab inner pinnae dogs. It then cultured, identified using matrix‐assisted laser desorption ionisation time‐of‐flight mass spectrometry, tested against 30 different clinical one American Type Culture Collection strain S. spot‐on‐the‐lawn technique. Its safety assessed through modified Kirby–Bauer disc diffusion susceptibility test. Results inhibited growth all . The mean value inhibition halo 11.3 mm. A significant positive correlation (Pearson's linear = 0.444; p 0.014) noted between inhibitory halos formed by produced discs same isolates. demonstrated sensitivity antimicrobials. Conclusions Clinical Relevance indicates that commensal bacteria skin, specifically , control bacterial infections caused can be promising complementary or therapy antibiotics relevant animal human health.

Language: Английский

Citations

0
Effect of Bacillus velezensis MT9 on Nile Tilapia (Oreochromis Niloticus) Intestinal Microbiota DOI Creative Commons
Matteo Calcagnile,

Elisa Quarta,

Alessandro Sicuro

et al.

Microbial Ecology, Journal Year: 2025, Volume and Issue: 88(1)

Published: May 1, 2025

Language: Английский

Citations

0
Inhibition of Candida albicans virulence factor by cyclic dipeptides derived from Aeromonas veronii V03 DOI Creative Commons
Jinendiran Sekar,

Gokul Parasuraman,

Dhanasekaran Dharumadurai

et al.

Published: Oct. 25, 2024

Abstract Candida albicans is the most common human fungal pathogen with high mortality rates and limited antifungal treatments. Inhibition of C. pathogenesis by targeting virulence factors provides a promising strategy for development novel drugs overcoming drug resistance. In this study, four structurally different cyclic dipeptides (or diketopiperazine(DKP) were isolated identified as cyclo(L-Pro-L-Leu), cyclo(L-Pro-L-Val), cyclo(D-Pro-L-Phe), cyclo(L-Pro-D-Tyr) from Aeromonas veronii V03 their antimicrobial potentials evaluated. Results revealed that DKPs exhibited antibacterial activity against bacterial pathogens, such Staphylococcus aureus, Proteus mirabilis , Pseudomonas aeruginosa, hydrophila . Importantly, cyclo(D-Pro-L-Phe) lacking hydroxyl groups showed potent inhibitory effects non-albicans species low concentrations. Moreover, inhibited traits albicans, including yeast-to-hyphae transition, secreted hydrolases (aspartic proteases phospholipase) biofilm formation in dose-dependent manner. Collectively, our findings suggest derived A. could potentially be developed antivirulence agents infection.

Language: Английский

Citations

0
Adhesion Properties and Pathogen Inhibition of Vaginal-Derived Lactobacilli DOI
Alessandra Pino, Kaisa Hiippala, Aki Ronkainen

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

Citations

0
Effect of linex treatment on IFN-γ and IL-4 in mice infected with Trichinella DOI Creative Commons
Shimaa Atta,

Zeinab Fahmy,

Eman A. H. Selim

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 28, 2024

Abstract Trichinellosis is a zoonotic, foodborne parasitic infection causing muscle damage. This study investigated the potential therapeutic effects of commercially available probiotic treatment Linex, both alone and in combination with Albendazole (ALB), on intestinal muscular stages Trichinella spiralis mice, assessing outcomes through parasitological, immunological, histopathological measures. first to demonstrate synergistic effect combining Linex for trichinellosis treatment. By enhancing parasitological immunological outcomes, this combined therapy not only significantly reduces parasite burden but also modulates immune response, shifting it toward protective Th1 profile. In terms, highest adult larval count reduction was observed (100%, 97.7%) respectively. Lesser percentage were recorded (43.2%, 88.4%) Histopathologically there amelioration inflammatory cellular infiltration all treated groups best results Immunologically, serum IFN-γ levels increased treatment, while IL-4 IL-13 level decreased To conclude; mice infected T. spirals could ameliorate improve response.

Language: Английский

Citations

0