Chitosan Nanoparticle Encapsulation of Thymus Capitatus Essential Oil: In Vitro Release, Antioxidant, Antibacterial Activity and Cytotoxicity in MDA-MB-231 Cells DOI
Huseyin Beyaz, Doğa Kavaz, Nahit Rizaner

et al.

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: March 31, 2025

Thymus capitatus (Th. Ca) is known to treat mouth ulcers and respiratory infections in Cyprus. However, antioxidant, antibacterial cytotoxic potential of Th. Ca. EO on MDA-MB-231 cells its' encapsulation into nanoparticles has not been well studied. Therefore, we aimed analyse the antibacterial, potential, loading efficiency vitro release profile both Chitosan Nanoparticle (Ch. Np) - EO. GC-MS analysis revealed 53.97% carvacrol, 14.53% borneol 12.09% sabinene presence The Ch. Np. was calculated as 35.27% reached a maximum 68% pH 7 for two weeks. Minimum Inhibitory Concentration (MIC) assay showed that E. coli had an MIC50 0.3215 mg/ml while B. subtilis 0.5304 mg/ml. antioxidant activity assessed by performing DPPH with IC50 = 440 μg/ml. Trypan Blue Assay 60 µg/ml significantly reduced cell viability 10.7% at 48h 20.06% 72h. Overall, shown promising formulation pharmaceutical industry.

Language: Английский

Chitosan Nanoparticle Encapsulation of Thymus Capitatus Essential Oil: In Vitro Release, Antioxidant, Antibacterial Activity and Cytotoxicity in MDA-MB-231 Cells DOI
Huseyin Beyaz, Doğa Kavaz, Nahit Rizaner

et al.

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: March 31, 2025

Thymus capitatus (Th. Ca) is known to treat mouth ulcers and respiratory infections in Cyprus. However, antioxidant, antibacterial cytotoxic potential of Th. Ca. EO on MDA-MB-231 cells its' encapsulation into nanoparticles has not been well studied. Therefore, we aimed analyse the antibacterial, potential, loading efficiency vitro release profile both Chitosan Nanoparticle (Ch. Np) - EO. GC-MS analysis revealed 53.97% carvacrol, 14.53% borneol 12.09% sabinene presence The Ch. Np. was calculated as 35.27% reached a maximum 68% pH 7 for two weeks. Minimum Inhibitory Concentration (MIC) assay showed that E. coli had an MIC50 0.3215 mg/ml while B. subtilis 0.5304 mg/ml. antioxidant activity assessed by performing DPPH with IC50 = 440 μg/ml. Trypan Blue Assay 60 µg/ml significantly reduced cell viability 10.7% at 48h 20.06% 72h. Overall, shown promising formulation pharmaceutical industry.

Language: Английский

Citations

0