NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(9)

Published: Feb. 25, 2025

During cortical development, radial glial cells (neural stem cells) initially are neurogenic, generating intermediate progenitor that exclusively produce glutamatergic pyramidal neurons. Next, generate tripotential (Tri-IPCs) give rise to astrocytes and oligodendrocytes, olfactory bulb interneurons. The molecular mechanisms underlying the transition from neurogenesis gliogenesis, subsequent fate determination of astrocytes, interneurons, remain unclear. Here, we report extracellular signal-regulated kinase (ERK) signaling plays a fundamental role in promoting gliogenesis generation Tri-IPCs. Additionally, sonic hedgehog-smoothened-glioma-associated oncogene homolog (SHH-SMO-GLI) activator has an auxiliary function ERK during these processes. We further demonstrate that, Tri-IPCs, NOTCH is crucial for while prominent oligodendrocyte specification, SHH required provide evidence suggesting this mechanism conserved both mice humans. Finally, propose unifying principle mammalian gliogenesis.

Language: Английский

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A dyad of human-specific NBPF14 and NOTCH2NLB orchestrates cortical progenitor abundance crucial for human neocortex expansion

Science Advances, Journal Year: 2025, Volume and Issue: 11(13)

Published: March 26, 2025

We determined the roles of two coevolved and coexpressed human-specific genes, NBPF14 NOTCH2NLB , on abundance cortical progenitors that underlie evolutionary expansion neocortex, seat higher cognitive abilities in humans. Using automated microinjection into apical (APs) embryonic mouse neocortex electroporation APs chimpanzee cerebral organoids, we show promotes delamination AP progeny, by promoting oblique cleavage plane orientation during division, leading to increased key basal progenitor type, radial glia. In contrast, proliferation, pool. When expressed together, exert coordinated effects, resulting while maintaining self-renewal APs. Hence, these genes orchestrate behavior APs, lineages their a manner essential for human neocortex.

Language: Английский

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Electrographic seizure Possibly contributes to The epileptogenesis of Acquired epilepsy

Medical Hypotheses, Journal Year: 2024, Volume and Issue: unknown, P. 111548 - 111548

Published: Dec. 1, 2024

Language: Английский

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