Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Bone biomaterials have become essential medical materials in the standard clinical treatment of bone defects. The paradigm has shift progressed from bioinert, guidingosteoblasts‐guided, stem cells‐regulated, and osteoimmunomodulation. However, osteogenic efficacy requires further enhancement, primarily due to inherent challenges precise An important but overlooked event is blood clot formation, as initial phase tissue repair, inevitable interaction between biomaterials. It results assembling a biomaterial–blood complex (BBCC). This acts crucial starting point for subsequent We firstly reviewed shifts concept “osteo‐coagulo‐immunomodulation” was proposed which elucidates spatiotemporal continuum events comprising biomaterial coagulation immune responses, emphasizing role key components clots osteoimmunomodulation (such fibrin network, red cells, platelets, complement). Building on framework, strategies were inroduced optimize BBCC design by harnessing unique properties modulating functions components. innovative aims establish new subdiscipline field research stimulate exploration into osteo‐coagulo‐immunomodulation.

Language: Английский