Bacteria and fungi of the lung: allies or enemies? DOI Creative Commons

Enrico Garaci,

Marilena Pariano,

Emilia Nunzi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Moving from the earlier periods in which lungs were believed to represent sterile environments, our knowledge on lung microbiota has dramatically increased, first descriptions of microbial communities inhabiting healthy and definition ecological rules that regulate its composition, identification changes occur pathological conditions. Despite limitations as a microbiome reservoir due low biomass abundance, defining composition function upper lower airways may help understanding impact local homeostasis disruption diseases. In particular, metabolic immune significance microbes, their presence or lack thereof, health disease states could be valuable development novel druggable targets treatments. Next-generation sequencing identified intricate inter-microbe association networks comprise true mutualistic antagonistic direct indirect relationships respiratory tract. this review, tripartite interaction bacteria, fungi mammalian host is addressed provide an integrated view microbial-host cross-talk diseases perspective.

Language: Английский

The impact of environmental factors on respiratory tract microbiome and respiratory system diseases DOI Creative Commons
Ying Ge, Guo Tang,

Yawen Fu

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 4, 2025

Abstract The respiratory tract microbiome, a complex ecosystem of microorganisms colonizing the mucous layers and epithelial surfaces along with their associated microenvironment, plays vital role in maintaining function promoting maturation immune system. Current research suggests that environmental changes can disrupt microbiota, potentially leading to disease. This review summarizes existing on impact factors microbiome diseases, aiming offer new insights into prevention treatment

Language: Английский

Citations

0
Bacteria and fungi of the lung: allies or enemies? DOI Creative Commons

Enrico Garaci,

Marilena Pariano,

Emilia Nunzi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Moving from the earlier periods in which lungs were believed to represent sterile environments, our knowledge on lung microbiota has dramatically increased, first descriptions of microbial communities inhabiting healthy and definition ecological rules that regulate its composition, identification changes occur pathological conditions. Despite limitations as a microbiome reservoir due low biomass abundance, defining composition function upper lower airways may help understanding impact local homeostasis disruption diseases. In particular, metabolic immune significance microbes, their presence or lack thereof, health disease states could be valuable development novel druggable targets treatments. Next-generation sequencing identified intricate inter-microbe association networks comprise true mutualistic antagonistic direct indirect relationships respiratory tract. this review, tripartite interaction bacteria, fungi mammalian host is addressed provide an integrated view microbial-host cross-talk diseases perspective.

Language: Английский

Citations

0