Pakistan Armed Forces Medical Journal,
Journal Year:
2023,
Volume and Issue:
73(2), P. 427 - 30
Published: April 18, 2023
Objective:
To
look
for
the
factors
associated
with
outcomes
in
patients
managed
invasive
fungal
infections
at
Infectious
Diseases
Department
of
a
Tertiary
Care
Hospital
Study
Design:
Comparative
cross-sectional
study
Place
and
Duration
Study:
Diseases,
Pak
Emirates
Military
Hospital,
Rawalpindi
Pakistan,from
Apr
2021
to
Sep
2022.
Methodology:
A
total
90
different
types
diagnosed
by
consultant
infectious
diseases
were
recruited.
First,
they
given
standard
treatment
infection;
as
per
guidelines.Then,
followed
up
one
month
an
outcome.
Results:
Out
included
study,
62(68.8%)
had
good
outcome,
while
28(31.2%)
poor
The
mean
age
recruited
our
study
was
39.54±6.27
years.
Of
all
participants,
65(72.2%)
male,
25(27.8%)
female.
Statistical
analysis
revealed
that
poorly
controlled
diabetes,
COVID-19
infection
HIV
positive
statistically
significantly
participants
(p-value<0.05).
Conclusion:
Considerable
number
outcome
study.
presence
being
participants.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(11), P. 788 - 788
Published: Nov. 13, 2024
Invasive
aspergillosis
is
a
rare
but
severe
fungal
infection
primarily
affecting
immunocompromised
individuals.
The
Coronavirus
Disease-2019
(COVID-19)
pandemic
has
introduced
new
complexities
in
managing
due
to
the
widespread
use
of
corticosteroids
for
treating
COVID-19-related
respiratory
distress,
which
can
increase
susceptibility
infections.
Here,
we
present
challenging
case
progressive
cerebral
complicated
by
cavernous
sinus
thrombosis
(CST)
67-year-old
male
with
history
COVID-19.
patient,
initially
misdiagnosed
temporal
arteritis,
received
pulse
corticosteroid
therapy
twice
before
presenting
persistent
left-sided
headaches
and
vision
loss.
Cranial
imaging
revealed
findings
consistent
sinusitis,
Tolosa–Hunt
syndrome,
orbital
pseudotumor,
progressed
despite
initial
antifungal
therapy.
Subsequent
magnetic
resonance
indicated
an
invasive
mass
extending
into
left
other
intracranial
structures,
raising
suspicion
aspergillosis.
A
transsphenoidal
biopsy
confirmed
Aspergillus
infection,
leading
voriconazole
Despite
aggressive
treatment,
follow-up
significant
progression,
extension
right
frontal
region
sinus.
patient
then
developed
visual
impairment
eye
was
diagnosed
CST
secondary
sinusitis.
Management
included
combination
systemic
antifungals
antibiotics;
however,
declined
surgical
intervention.
This
underscores
diagnostic
challenges
rapid
progression
associated
post-COVID-19
patients
treated
corticosteroids.
report
highlights
need
heightened
clinical
prompt,
targeted
interventions
similar
cases
improve
outcomes.
Further
research
required
understand
optimal
management
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Coronavirus
disease
2019
(COVID-19)
was
caused
by
a
novel
severe
acute
respiratory
syndrome
related
coronavirus
(SARS-CoV-2)
that
occurred
in
late
and
soon
emerged
as
global
pandemic.
Even
after
recovering
from
the
initial
infection,
approximately
45%
of
patients
experience
persistent
symptoms,
known
post-COVID
syndromes
or
long
COVID,
which
can
endure
for
weeks
to
months.
Among
prominent
lingering
symptoms
are
fatigue,
cognitive
impairment
(commonly
referred
brain
fog),
musculoskeletal
disorders.
Brain
fog
manifests
confusion,
difficulty
focusing,
memory
loss.
Although
exact
cause
deficits
induced
SARS-CoV-2
remains
unclear,
it
is
speculated
chronic
inflammation
resulting
residual
virus
remnants
body’s
reservoirs
stress-released
peptides
may
play
significant
role.
This
chapter
aims
delve
into
etiology
recent
advancements
treating
associated
with
COVID-19,
shedding
light
on
our
understanding
this
complex
phenomenon
potential
therapeutic
strategies.
Boletín Venezolano de Infectología,
Journal Year:
2023,
Volume and Issue:
33(2)
Published: Feb. 22, 2023
Las
especies
de
Scedosporium
son
consideradas
patógenos
oportunistas
emergentes,
que
afectan
a
pacientes
inmunocomprometidos
o
con
respuesta
inmunológica
normal.
La
enfermedad
invasiva
grave
supera
tasas
mortalidad
del
80
%.
Se
describe
caso
afectación
pulmonar
causada
por
el
complejo
en
un
paciente
masculino
75
años
edad,
procedente
Caracas,
Venezuela,
diabetes
mellitus
tipo
2,
infección
respiratoria
baja,
dos
infecciones
previas
coronavirus
2019
(COVID-19)
e
imagen
radiológica
lesión
ocupación
espacio
basal
izquierdo.
envió
al
laboratorio
microbiología
porción
aproximadamente
1
cm2
tejido
pulmonar,
solicitando
estudios
micológicos
y
para
micobacterias.
Al
examen
directo
KOH
20
%
se
observó
fragmento
hifa
hialina
tabicada.
A
los
12
días
incubación
hubo
crecimiento
agar
Sabouraud
dextrosa
más
gentamicina
colonias
vellosas
pigmentado
difusible
color
amarillo
pálido
mostaza.
realizó
las
azul
algodón,
observándose
estructuras
compatibles
Scedosporium.
spp.,
es
segundo
hongo
filamentoso,
después
Aspergillus
causante
respiratorias
bajas.
El
fue
tratado
voriconazol
diagnóstico
micológico
una
evolución
satisfactoria.
órganos
internos
como
pulmones,
similar
descrito.
COVID-19
factor
predisponente
adquirir
fúngicas
poco
frecuentes.
cumple
rol
importante
micosis
causadas
hongos
inusuales.
RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(7), P. 1351 - 1361
Published: Jan. 1, 2023
Novel
substituted
monohydrazides
synthesized
for
this
study
displayed
broad-spectrum
activity
against
various
fungal
strains,
including
a
panel
of
clinically
relevant
Candida
auris
strains.
Pakistan Armed Forces Medical Journal,
Journal Year:
2023,
Volume and Issue:
73(2), P. 427 - 30
Published: April 18, 2023
Objective:
To
look
for
the
factors
associated
with
outcomes
in
patients
managed
invasive
fungal
infections
at
Infectious
Diseases
Department
of
a
Tertiary
Care
Hospital
Study
Design:
Comparative
cross-sectional
study
Place
and
Duration
Study:
Diseases,
Pak
Emirates
Military
Hospital,
Rawalpindi
Pakistan,from
Apr
2021
to
Sep
2022.
Methodology:
A
total
90
different
types
diagnosed
by
consultant
infectious
diseases
were
recruited.
First,
they
given
standard
treatment
infection;
as
per
guidelines.Then,
followed
up
one
month
an
outcome.
Results:
Out
included
study,
62(68.8%)
had
good
outcome,
while
28(31.2%)
poor
The
mean
age
recruited
our
study
was
39.54±6.27
years.
Of
all
participants,
65(72.2%)
male,
25(27.8%)
female.
Statistical
analysis
revealed
that
poorly
controlled
diabetes,
COVID-19
infection
HIV
positive
statistically
significantly
participants
(p-value<0.05).
Conclusion:
Considerable
number
outcome
study.
presence
being
participants.
