Predicting intracranial involvement: Unveiling perineural spread in COVID-19-associated mucormycosis, a novel phenomenon

Medical Mycology, Journal Year: 2023, Volume and Issue: 62(1)

Published: Dec. 21, 2023

Abstract This study aimed to investigate the risk factors associated with intracranial involvement in COVID-19-associated mucormycosis (CAM) and develop a nomogram model for predicting of involvement, specific focus on perineural spread. An ambispective analysis was conducted 275 CAM patients who received comprehensive treatment. Univariable multivariable logistic regression analyses were performed identify independent factors, created based results analysis. The performance evaluated using receiver operating characteristic (ROC) curve, discriminatory capacity assessed area under curve (AUC). model's calibration through Hosmer Lemeshow test. In results, revealed that age (OR: 1.23, 95% CI 1.06–3.79), HbA1c 7.168, 1.724–25.788), spread 6.3, 1.281–19.874), disease stage CAM. developed demonstrated good discriminative an AUC 0.821 (95% 0.713–0.909) as indicated by ROC curve. showed well-calibrated, test yielded P-value 0.992, indicating fit model. conclusion, this found particularly exhibits spread, which is predictive factor involvement. A incorporating age, HbA1c, stage, successfully both in-patient out-patient settings.

Language: Английский

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Rapid Cytological Diagnosis With Evaluation of Pre- and Post-Therapeutic Fungal Morphological Characteristics in Mucormycosis

Journal of Clinical Medicine Research, Journal Year: 2023, Volume and Issue: 15(1), P. 31 - 37

Published: Jan. 1, 2023

Background: Mucormycosis necessitates rapid diagnosis and treatment. Microscopy culture have been considered the gold standard for but both take time of 3 - 5 days. KOH mount is another method fungal identification that takes 1 2 h, it has its own limitations. This study evaluated crush smear as a means cytological diagnosis. Methods: Biopsy tissue (pre-treatment) from clinically suspicious mucormycosis patients (n = 52) was received in normal saline crush/imprint smears were prepared; remaining processed routine biopsy specimen. After initial identification, managed according to clinical protocol. Random post-therapeutic samples some these 19) also obtained again cytologically. Results: Crush showed sensitivity/specificity 77.7%/75.0% with histopathology 72.2%/62.5% culture, respectively, while had values 71.4%/70.5% 79.3%/69.5% respectively. Degenerative morphological characteristics cellular inflammatory infiltrate (predominantly neutrophilic) vicinity hyphae compared pre- post-treatment groups, we found statistically significant difference (P < 0.05) between them. Conclusion: Our preliminary results suggest cytology simple, rapid, cost-effective easily available diagnosing mucormycosis. Moreover, demonstrated alteration hyphal structure accompanying immune cell infiltration which may provide valuable insights into mechanism therapy/host response against pathogen. J Clin Med Res. 2023;15(1):31-37 doi: https://doi.org/10.14740/jocmr4835

Language: Английский

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Analog and Digital Protocols for Functional Prosthetic Rehabilitation of Post-COVID-19 Rhino-Orbito Cerebral Mucormycosis Maxillofacial Defects: A Case Series

Journal of Pharmacy And Bioallied Sciences, Journal Year: 2023, Volume and Issue: 15(Suppl 2), P. S1347 - S1350

Published: July 1, 2023

A BSTRACT The current study aims to present our clinical observations and experience gathered during the diagnosis, presentation, medical/surgical treatment, functional prosthetic rehabilitation of cases rhino-orbital/cerebral Mucormycosis patients. is an aggressive, life-threatening invasive fungal infection that occurs in people who are immune-compromised. rise ROCM second wave COVID-19 pandemic India suggests a more effective association between SARS-CoV-2 delta variant. treatment strategy for early diagnosis which critical successful outcome. initial step reduce or remove underlying risk factors followed by surgical excision debridement afflicted tissues supplemented with antifungal medication. first-line Liposomal Amphotericin B. Postsurgical resection defects rehabilitated either removable partial prosthesis (obturators) fixed zygomatic implant/patient-specific implant supported prosthesis. Management requires multidisciplinary approach. This case series highlights detailed medical, surgical, management modalities adopted team managing such dreaded disease may be used as tool formulation standardized prevention management/treatment/rehabilitation protocols future so morbidity mortality reduced endemic outbreak could averted.

Language: Английский

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Sobre infecciones bacterianas y fúngicas asociadas a COVID-19 en la población española

Published: Jan. 1, 2024

RBD: Dominios de unión

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Mucormycosis in an Immunocompetent Patient Recovering From Dengue Fever

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Mucormycosis is a rare yet aggressive fungal infection. Despite its rarity, India has experienced surge in cases during the post-COVID-19 era. The high mortality rate associated with this infection necessitates early diagnosis, intervention, and treatment. Typically, it observed immunocompromised patients, where disease progresses rapidly leads to unfavorable outcomes. However, occurrences previously healthy individuals are not uncommon. Dengue been occasionally mucormycosis post-recovery phase. This case report highlights importance of heightened clinical suspicion intervention patients recent dengue infections chronic sinus conditions. It explores potential risk factors, such as dengue-related immune alterations, environmental exposures, anatomical alterations that may contribute development otherwise individuals.

Language: Английский

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