Pneumocystis jirovecii Pneumonia after Heart Transplantation: Two Case Reports and a Review of the Literature DOI Creative Commons

Carlo Burzio,

Eleonora Balzani, Silvia Corcione

et al.

Pathogens, Journal Year: 2023, Volume and Issue: 12(10), P. 1265 - 1265

Published: Oct. 21, 2023

Post-transplant Pneumocystis jirovecii pneumonia (PcP) is an uncommon but increasingly reported disease among solid organ transplantation (SOT) recipients, associated with significant morbidity and mortality. Although the introduction of PcP prophylaxis has reduced its overall incidence, prevalence continues to be high, especially during second year after transplant, period following discontinuation. We recently described two cases occurring more than one heart (HT) in patients who were no longer receiving according local protocol. In both cases, was diagnosed diagnosis a viral illness, resulting significantly increased risk for PcP. While current guidelines recommend up 6–12 months transplantation, that they only suggest extended regimen high-risk patients. Recent studies have identified several new factors may linked infection, including medication regimens patient characteristics. Similarly, indication non-HIV been expanded relation medications therapeutic immune-mediated diseases. our experience, first successfully treated non-invasive ventilation, while required tracheal intubation, invasive extracorporeal CO2 removal due severe respiratory failure. The aim this double case report review timing HT, specific potential determinants prompt approach critically ill will also present possible proposal future investigations on indications long-term prophylaxis.

Language: Английский

Fungal-Induced Hemophagocytic Lymphohistiocytosis: A Literature Review in Non-HIV Populations DOI Creative Commons
Chia‐Yu Chiu, Rachel Hicklen, Dimitrios P. Kontoyiannis

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(2), P. 158 - 158

Published: Feb. 18, 2025

We performed a thorough search of the literature published through December 2024 with no date exclusions on invasive fungal infection (IFI)-induced hemophagocytic lymphohistiocytosis (HLH) in non-human immunodeficiency virus (HIV) patients. The frequency IFI-induced HLH reported across 16 articles was 9%. Of 116 identified cases available clinical information, 53% occurred immunocompromised IFIs were usually disseminated (76%), Histoplasma capsulatum being most common pathogen (51%). IFI and diagnosed simultaneously (78%). 30-day survival rate 64%. Reported had significant heterogeneity patient characteristics, management strategies, outcomes.

Language: Английский

Citations

1
A rare case of Candida albicans-associated meningitis; A case report study DOI Creative Commons

Sareh Askari,

Mahila Monajati,

Sedigheh Erfani

et al.

Clinical Infection in Practice, Journal Year: 2025, Volume and Issue: unknown, P. 100490 - 100490

Published: April 1, 2025

Language: Английский

Citations

1
Invasive Aspergillosis after Renal Transplantation DOI Creative Commons
Liyanage Shamithra Madhumali Sigera, David W. Denning

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(2), P. 255 - 255

Published: Feb. 15, 2023

Over 95,000 renal transplantation procedures were completed in 2021. Invasive aspergillosis (IA) affects about 1 250 to 43 transplant recipients. About 50% of cases occur the first 6 months after transplantation; median time onset is nearly 3 years. Major risk factors for IA include old age, diabetes mellitus (especially if prior diabetic nephropathy), delayed graft function, acute rejection, chronic obstructive pulmonary disease, cytomegalovirus and neutropenia. Hospital construction, demolition activities, residential refurbishments also increase risk. Parenchymal infection most common (~75%), bronchial, sinus, cerebral, disseminated disease are less common. Typical features fever, dyspnea, cough, hemoptysis seen patients, but 20% have non-specific general illness. Non-specific infiltrates nodules commonest radiological features, with bilateral carrying a worse prognosis. Bronchoscopy direct microscopy, fungal culture, Aspergillus antigen fastest means establishing diagnosis; positive serum presages outcome. Standard therapy includes voriconazole, isavuconazole, or posaconazole, great attention necessary assess likely drug–drug interactions. Liposomal amphotericin B echinocandins effective. A reduction stopping immunosuppression needs careful consideration, given overall mortality renal-transplanted patients; continuing corticosteroid diagnosis increases by 2.5 times. Surgical resection addition gamma interferon should be considered.

Language: Английский

Citations

17
Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis DOI Creative Commons
Sayed E. El-Sayed, Neveen A. Abdelaziz, Ghadir S. El-Housseiny

et al.

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Jan. 12, 2024

Abstract Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed promising antimycotic activity. This aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) control skin fungal ailments since nanosponges augment retention tested agents skin. Box-Behnken design used produce optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), particle size (PS) were assigned as dependent parameters, while independent process parameters polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, speed. The carbopol 940 then created by incorporating nanosponges. fit Higuchi’s kinetic release model best, according vitro drug release. Stability photodegradation studies revealed that NS-HG remained stable under conditions. formulation also higher antifungal activity against Candida albicans compared fluconazole. In vivo ODHP-NS-HG increased survival rates, wound contraction, healing gap inhibited inflammation other groups. histopathological examinations Masson’s trichrome staining improved records collagen deposition. Moreover, permeability through rats’ 1.5-folds isoconazole 1%. Therefore, based on these results, is potential carrier for enhanced topical delivery ODHP. Our pioneering research development produced naturally bacteria. Key points • successfully formulated statistically . new formula exhibited good stability, release, C. fluconazole Ex permeability, analysis high evidenced measurement various biochemical examination

Language: Английский

Citations

8
A Systematic Review of the Therapeutic Outcome of Mucormycosis DOI Creative Commons
Liyanage Shamithra Madhumali Sigera, David W. Denning

Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 11(1)

Published: Dec. 30, 2023

Mucormycosis is a potentially lethal mycosis. We reviewed peer-reviewed publications on mucormycosis to assess therapeutic outcomes.

Language: Английский

Citations

16
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections DOI
Qian Xie, Qinhui Li, Hong Fang

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(3), P. 316 - 327

Published: July 5, 2024

Language: Английский

Citations

5
Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis DOI Creative Commons

Anshuman Sengupta,

Animesh Ray, Ashish Datt Upadhyay

et al.

The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

5
Photoinduced Chemiluminescence Determination of Prednisolone Using Lucigenin‐Cobalt 5,10,15,20‐Tetra(4‐Pyridyl)‐21H,23H‐Porphine System DOI
Sayed Yahya Kazemi

Luminescence, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 1, 2025

ABSTRACT Sensitive and precise assay of prednisolone, a steroid hormone, has received great attention due to its significant role in the treatment series diseases. In this study, we have developed simple, quick, accurate technique part measure prednisolone. Cobalt 5,10,15,20‐tetra(4‐pyridyl)‐21H,23H‐porphine (CoTPyP) as mimic peroxidase catalyzes chemiluminescence (CL) reaction lucigenin for first time. CoTPyP impact on CL signal. Furthermore, system been successfully used prednisolone flow‐injection test. The findings showed that UV irradiation led an unimolecular photochemical could enhance yield high‐energy intermediate cause higher emission. Under ideal experimental circumstances, intensity was shown be proportionate concentration range 0.1–170 μg mL −1 ( r = 0.9925, n 4). A detection limit 0.072 observed. Compared with HPLC approach, our proposed method provides sensitive, fast, efficient analysis pharmaceutical formulations biological fluids.

Language: Английский

Citations

0
Unveiling ferroptosis genes and inhibitors in diabetic retinopathy through single-cell analysis and docking simulations DOI Creative Commons
Md Maqsood Ahamad Khan, Ananya Ganguly, Shubhrajit Barman

et al.

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 41, P. 101932 - 101932

Published: Jan. 31, 2025

Language: Английский

Citations

0
Fungal microbiota in COPD patients during exacerbations DOI
Weronika Gawor, Katarzyna Góralska,

Sandra Galant

et al.

Journal de Mycologie Médicale, Journal Year: 2025, Volume and Issue: 35(2), P. 101543 - 101543

Published: March 10, 2025

Language: Английский

Citations

0