The Human Cerebello-Hippocampal Circuit Across Adulthood

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Direct communication between the hippocampus and cerebellum has been shown via coactivation synchronized neuronal oscillations in animal models. Further, this novel cerebello-hippocampal circuit may be impacted by sex steroid hormones. The are dense with estradiol progesterone receptors relative to other brain regions. Females experience up a 90% decrease ovarian production after menopausal transition. Postmenopausal women show lower cerebello-cortical intracerebellar FC compared reproductive aged females. Sex hormones established modulators of both memory function synaptic organization non-human studies. However, investigation (CB-HP) limited studies small homogeneous samples young adults as it relates spatial navigation. Here, we investigate CB-HP 138 adult humans (53% female) from 35-86 years age, define its patterns, associations behavior, hormone levels, differences therein. We robust patterns CB HP sample. predicted found negative relationships age FC. As expected, levels exhibited positive CB-HP. higher progesterone. provide first characterization across middle older adulthood demonstrate that connectivity is sensitive levels. This work provides clear mapping human serves foundation for future neurological psychiatric diseases.

Language: Английский

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The confusing role of visual motion detection acuity in postural stability in young and older adults

Gait & Posture, Journal Year: 2025, Volume and Issue: 119, P. 63 - 69

Published: Feb. 27, 2025

Language: Английский

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Modulation of cerebellar homotopic connectivity by modified electroconvulsive therapy at rest: Study of first-episode, drug-naive adolescent major depressive disorder

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Are resting-state network alterations in late-life depression related to synaptic density? Findings of a combined 11C-UCB-J PET and fMRI study

Cerebral Cortex, Journal Year: 2025, Volume and Issue: 35(3)

Published: March 1, 2025

Abstract This study investigates the relationship between resting-state functional magnetic resonance imaging (rs-fMRI) topological properties and synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) density (SD) in late-life depression (LLD). 18 LLD patients 33 healthy controls underwent rs-fMRI, 3D T1-weighted MRI, 11C-UCB-J PET scans to assess SD. The rs-fMRI data were utilized construct weighted networks for calculating four global metrics, including clustering coefficient, characteristic path length, efficiency, small-worldness, six nodal degree, strength, local betweenness centrality. provided standardized uptake value ratios as SD measures. exhibited preserved organization, with reduced regions associated LLD, such medial prefrontal cortex (mPFC), increased basal ganglia cerebellar regions. Notably, a negative correlation was observed centrality mPFC depressive symptom severity. No significant alterations or associations found, challenging hypothesis that are molecular basis changes LLD. Our findings suggest other mechanisms may underlie connectivity these patients.

Language: Английский

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Altered cerebellar activation patterns in Alzheimer’s disease: An activation likelihood estimation Meta-Analysis

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103770 - 103770

Published: March 1, 2025

The past decade has seen an increased interest in the cerebellum, particularly non-motor behaviors. Emerging work across model systems and humans also implicated cerebellum Alzheimer's Disease (AD) mild cognitive impairment (MCI). While is not as being central to etiology of disease, it however recognized increasingly important, most certainly immune from disease-related pathology atrophy. In cognitively normal older adults (OA), been conceptualized critical scaffolding for cortical function. This may extend AD MCI. With respect functional imaging, this largely unexplored AD, a nascent literature. there are very few studies focused on at stage, meta-analysis provides powerful tool expanding our knowledge neurodegenerative and, turn, hypothesis generation. We took advantage activation likelihood estimation (ALE) investigate overlap present existing but included exploratory analysis MCI, based papers available search. Our total 29 studies, representing data 236 individuals with 159 382 OA. Across these no significant cerebellar though Analyses group differences suggest that patterns indicative both greater reduced AD/MCI relative all findings, was primarily centered Crus I Lobule VI. These findings function negatively impacted which turn impact behavior symptomatology.

Language: Английский

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Effects of age on postoperative oral function in older adults with oral squamous cell carcinoma and its cutoff values: a cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 21, 2025

Abstract This study aimed to investigate the influence of age on postoperative oral function in older adults with squamous cell carcinoma and its cutoffs. 102 patients (74 males; 28 females) were treated according National Comprehensive Cancer Network guidelines at Department Oral Maxillofacial Surgery, Shimane University Hospital, between September 2019 March 2023 included. Their mean was 69.6 years. Background data obtained from medical records, measurements performed day before discharge. Final analysis using receiver operating characteristic (ROC) curve propensity score. The primary tumor site tongue 45 (44.1%), gingiva 41 (40.2%), other sites 16 (15.7%) patients. ROC showed a cutoff 75 years for occlusal force. score method that odds ratio 4.32 (confidence interval: 1.48 − 12.55 [ P = 0.01]) Treatment is independently associated function, incidence dysfunction approximately four times higher aged > development measures recovery may be particularly necessary adult

Language: Английский

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A polymorphism in the BIN1 gene influences its expression and is associated with the risk of Alzheimer's disease: An integrated analysis

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Background The correlation between rs7561528 and the risk of Alzheimer's disease (AD) has been reported with varying results, potential mechanism in influencing AD remains unexplored. Objective This study aims to examine impact on investigate its mechanism. Methods initially synthesized previously published data risk. Subsequently, an expression quantitative trait loci analysis was conducted determine whether modulates BIN1 human brain tissue. Results Our findings revealed that rs7561528A allele notably escalates Caucasian population (OR = 1.17, 95% CI 1.07–1.28, I² 33.5%). Similarly, rs7561528AG genotype also significantly heightens same 1.18, 1.05–1.31, 21.7%). Further demonstrated combined rs7561528AA + AG substantially amplifies 1.21, 1.08–1.36, 30.0%). Ultimately, we discovered Conclusions could potentially affect by regulating levels discovery enhances our understanding novel mechanisms through which may contribute

Language: Английский

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Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(6)

Published: April 15, 2025

Cerebellar volumetric changes are intricately linked to aging, with distinct patterns across its transverse zones, the functional subdivisions characterized by unique cytoarchitectural and connectivity profiles. Despite research efforts, cerebellar aging process in health neurological disorders remains poorly understood. In this study, we investigated effects of age sex on total cerebellum, zone, lobule volumes using MRI data from over 45,000 participants compiled six neuroimaging datasets. We also propose a framework for estimating cerebellum as an indicator health. Significant age-dependent volume reductions were observed central zone (CZ; lobules VI VII) exhibiting steepest decline both disorders. This finding highlights CZ's vulnerability critical role cognitive emotional processing. found prominent differences changes. Males exhibited smaller intracranial (TIV)-adjusted faster reduction than females mild impairment (MCI), Alzheimer disease (AD), Parkinson (PD). contrast, schizophrenia (SZ) cocaine use disorder (CUD) revealed males. Patients MCI, AD, PD experienced more pronounced atrophy posterior (PZ) nodular (NZ) zones compared age-matched healthy controls, while SZ patients CZ. CUD, non-significant was all controls. Moreover, our notable difference between individuals patients. Finally, charted individuals, focusing capturing subdivisions. These findings underscore potential analysis biomarker early detection monitoring neurodegenerative neuropsychiatric Our novel approach complements enhances MRI-based analyses, providing essential insights into pathogenesis neurodegeneration, chronic conditions.

Language: Английский

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Alzheimer’s disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity

Neurobiology of Aging, Journal Year: 2025, Volume and Issue: 151, P. 107 - 116

Published: April 18, 2025

Language: Английский

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Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice

Published: May 21, 2025

Abstract Age-related neurodegenerative diseases involve reduced cell numbers and impaired behavioral capacity. Neurodegeneration deficits also occur during aging, notably in the absence of disease. The cerebellum, which modulates movement cognition, is susceptible to loss both aging Here, we demonstrate that cerebellar Purkinje aged mice not spatially random but rather occurs a pattern parasagittal stripes. We find exhibit motor coordination more severe tremor compared younger mice. However, relationship between patterned dysfunction straightforward. Examination postmortem samples human cerebella from neurologically typical individuals supports presence selective cells aging. These data reveal spatiotemporal cellular substrate for cerebellum may inform about how neuronal vulnerability leads neurodegeneration ensuing deterioration behavior.

Language: Английский

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