Intermuscular coherence as an early biomarker for amyotrophic lateral sclerosis: The protocol for a prospective, multicenter study DOI Creative Commons
Naoum P. Issa, Serdar Aydin, Eric C. Polley

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0303053 - e0303053

Published: May 22, 2024

Objective To describe the protocol of a prospective study to test validity intermuscular coherence (IMC) as diagnostic tool and biomarker upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Methods This is multicenter, study. IMC muscle pairs lower limbs gathered ∼650 subjects across three groups using surface electrodes conventional electromyography (EMG) machines. The following will be tested: 1) neurotypical controls; 2) patients with symptomatology suggestive for early ALS but not meeting probable or definite by Awaji Criteria; 3) known mimic. recruitment period between 3/31/2021 12/31/2025. Written consent sought from subject subject’s legally authorized representative during enrollment. Results endpoints this include: whether adding criteria improve its sensitivity can allow diagnosis earlier; constructing database different ages, genders, ethnicities. Significance may validate new inexpensive, painless, widely available ALS.

Language: Английский

Added load increases the peak frequency of intermuscular coherence DOI
Nicholas W. Baumgartner,

Jacquelyn P. Hill,

Shail Bhatnagar

et al.

Journal of Electromyography and Kinesiology, Journal Year: 2024, Volume and Issue: 76, P. 102881 - 102881

Published: March 31, 2024

Language: Английский

Citations

1
Intermuscular coherence as an early biomarker for amyotrophic lateral sclerosis: The protocol for a prospective, multicenter study DOI Creative Commons
Naoum P. Issa, Serdar Aydin, Eric C. Polley

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0303053 - e0303053

Published: May 22, 2024

Objective To describe the protocol of a prospective study to test validity intermuscular coherence (IMC) as diagnostic tool and biomarker upper motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Methods This is multicenter, study. IMC muscle pairs lower limbs gathered ∼650 subjects across three groups using surface electrodes conventional electromyography (EMG) machines. The following will be tested: 1) neurotypical controls; 2) patients with symptomatology suggestive for early ALS but not meeting probable or definite by Awaji Criteria; 3) known mimic. recruitment period between 3/31/2021 12/31/2025. Written consent sought from subject subject’s legally authorized representative during enrollment. Results endpoints this include: whether adding criteria improve its sensitivity can allow diagnosis earlier; constructing database different ages, genders, ethnicities. Significance may validate new inexpensive, painless, widely available ALS.

Language: Английский

Citations

0