Brain Derived Neurotrophic Factor in Pregnancy: Stress Responses and Fetal Neurodevelopment DOI Creative Commons

Aafia Afridi,

Matti Adam,

Soobia Pathan

et al.

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

BDNF was a protein that has crucial role in development of brain fetuses however its levels were affected by maternal stress response cause complications. Objective: To study the effects Brain Derived Neurotrophic Factor (BDNF) during pregnancy on developing fetus order to bring clinicopathological correlations. Methods: As PRISMA guidelines suggested, an extensive database search made from PubMed, Science Direct, and Google Scholar for articles released between 2016 2024. Included studies analyzed differences as function responses expressed increased activity changes brain. This review also included fetal neurodevelopmental issues which related biomarkers. used 60% with various locations. Results: The revealed strong relations high mothers’ reactions tangible cortisol some parts amygdaloid complex. effect observed be regulated through alteration plasticity BDNF. Additionally, concentration been associated such modifications weight biomarkers cord blood serum samples. Conclusions: Maternal hence critical driver outcomes newborns If implemented, this information may help understand how regulates types stresses mother experiences along development.

Language: Английский

Physically active pregnancies: Insights from the placenta DOI Creative Commons
Kristi B. Adamo, Alexandra D. Goudreau, Abbey E. Corson

et al.

Physiological Reports, Journal Year: 2024, Volume and Issue: 12(11)

Published: June 1, 2024

Abstract Physical activity (PA) positively influences pregnancy, a critical period for health promotion, and affects placental structure function in ways previously overlooked. Here, we summarize the current body of literature examining association between PA, placenta biology, physiology while also highlighting areas where gaps knowledge exist. PA during pregnancy induces metabolic changes, influencing nutrient availability transporter expression placenta. Hormones cytokines secreted contribute to benefits, with intricate interactions pro‐ anti‐inflammatory markers. Extracellular vesicles “‐omics” data suggest that gestational can shape affecting gene expression, DNA methylation, metabolite profiles, protein regulation. However, whether respond alter proteomic profiles remains be elucidated. The limited research on mitochondria physically active parents (gesP), has shown improvements mitochondrial antioxidant capacity, but relationship dynamics, lipid metabolism unexplored. Additionally, placenta‐immune microenvironment, angiogenesis, may confer positive effects neurodevelopment mental through vascularization, modulation brain‐derived neurotrophic factor. Ongoing exploration is crucial unraveling multifaceted impact environment.

Language: Английский

Citations

4
Changes in molecular biomarkers of neurotoxicity in newborns following prenatal exposure to organophosphate compounds DOI
Antonio F. Hernández, D. Romero, Beatriz González-Alzaga

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 374, P. 144204 - 144204

Published: Feb. 11, 2025

Language: Английский

Citations

0
Puberty-Associated Changes in Kiss1r, MC3R, and MC4R in the Ewe DOI Creative Commons

Ashleigh Caitlyn Thomson

Published: Jan. 1, 2024

The neural mechanisms that control the onset of puberty are not completely understood. In livestock, relies on an increase in gonadotropin releasing hormone (GnRH) and luteinizing (LH). Kisspeptin, neurokinin B, dynorphin neurons (KNDy) their receptors, Kiss1r, NK3R, KOR, respectively, important regulators puberty. Previous data from our laboratory has shown KNDy may be responding to other inputs, including melanocortin system, will affect timing Given this, we examined kisspeptin receptor (Kiss1r) mRNA expression GnRH as well examining 3 4 (MC3R/MC4R) throughout pubertal development. Ewes were ovariectomized a silastic estrogen implant was inserted two weeks before serial blood collection sacrifice at 5 months (prepubertal), 8 (peripubertal), 10 (postpubertal) age. Hypothalamic tissue perfused, obtained, analyzed by RNAscope. We hypothesized Kiss1r neurons, MC3R/MC4R arcuate nucleus (ARC) would association with puberty-related changes LH secretion. found percentage expressing increased ARC MC3R, but MC4R, development, area percent integrated density did change. There no significant This work supports idea sensitivity input aMSH responsiveness comprise part neurocircuitry involved

Language: Английский

Citations

0
Brain Derived Neurotrophic Factor in Pregnancy: Stress Responses and Fetal Neurodevelopment DOI Creative Commons

Aafia Afridi,

Matti Adam,

Soobia Pathan

et al.

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

BDNF was a protein that has crucial role in development of brain fetuses however its levels were affected by maternal stress response cause complications. Objective: To study the effects Brain Derived Neurotrophic Factor (BDNF) during pregnancy on developing fetus order to bring clinicopathological correlations. Methods: As PRISMA guidelines suggested, an extensive database search made from PubMed, Science Direct, and Google Scholar for articles released between 2016 2024. Included studies analyzed differences as function responses expressed increased activity changes brain. This review also included fetal neurodevelopmental issues which related biomarkers. used 60% with various locations. Results: The revealed strong relations high mothers’ reactions tangible cortisol some parts amygdaloid complex. effect observed be regulated through alteration plasticity BDNF. Additionally, concentration been associated such modifications weight biomarkers cord blood serum samples. Conclusions: Maternal hence critical driver outcomes newborns If implemented, this information may help understand how regulates types stresses mother experiences along development.

Language: Английский

Citations

0