Technium BioChemMed,
Journal Year:
2024,
Volume and Issue:
11, P. 91 - 101
Published: Dec. 21, 2024
Respiratory
viral
infections
are
a
major
cause
of
morbidity
and
mortality
in
children,
posing
significant
burden
on
healthcare
systems.
A
proper
understanding
the
epidemiology,
diagnostic
methods,
management
strategies
is
essential
to
improve
paediatric
care
avoid
unjustified
use
antibiotics,
thereby
contributing
fight
against
antimicrobial
resistance.
Aim:
This
study
aims
provide
comprehensive
synthesis
literature
respiratory
focusing
role
antibiotics
importance
preventive
measures.
Methodology:
For
this
review,
an
initial
87,000
articles
were
identified
from
seven
databases,
following
PRISMA
protocol.
After
removing
duplicates
applying
exclusion
criteria,
200
reviewed,
which
43
selected
for
final
synthesis.
Results:
The
highlights
diversity
agents
involved,
including
RSV,
influenza
viruses,
rhinoviruses.
It
emphasizes
that
effective
only
cases
bacterial
superinfections.
Vaccination
hygiene
measures
crucial
prevention,
while
health
education
plays
central
reducing
infection
incidence.
Conclusions:
Optimal
children
requires
multidisciplinary
approach
centred
prevention
accurate
diagnosis.
underscores
need
evidence-based
protocols,
as
well
communities.
These
findings
solid
foundation
developing
tailored
policies
contribute
improving
clinical
practices
paediatrics.
Pulmonary Medicine,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Background/Objective:
Respiratory
syncytial
virus
(RSV)
is
a
major
cause
of
bronchiolitis
in
infants
and
young
children.
Bronchiolitis,
an
acute
inflammation
the
lower
respiratory
tract,
can
lead
to
pneumonia,
failure,
death.
We
aimed
compare
incidence
severity
RSV
infection
children
aged
0–60
months
before
during
coronavirus
disease
2019
(COVID‐19)
pandemic.
Methods:
A
retrospective
chart
review
was
conducted
on
patients
who
tested
positive
for
between
May
1,
2018,
31,
2022,
community
hospital
Queens
County,
New
York
City,
United
States.
Comparisons
were
made
seasons
2018–2019
2019–2020
as
before,
2020–2021
2021–2022
COVID‐19
Severity
assessed
using
Bronchiolitis
Score
(BSS).
Data
analyzed
R
software,
p
value
<
0.05
considered
statistically
significant.
Results:
The
peaked
from
mid‐October
February,
whereas
first
season
pandemic
(2020–2021)
truncated
with
very
low
infection,
September
January,
highest
(37%)
frequency
at
any
given
point.
Patients
older
(
H
[2,
196.6]
=
12.5,
0.001,
95%
C
I
[5.4,
25.6])
had
milder
illness
187.5]
7.5,
0.01,
[2.1,
19.2]).
Conclusions:
observed
rate
hospitalization
second
began
earlier,
lasted
longer,
frequency.
Older
illnesses
affected
most
this
season.
epidemiology
burden
impacted
by
could
have
significant
ramifications
its
prevention
control
strategies.
Background:
Human
bocavirus
(HBoV)
has
emerged
as
a
pathogenic
cause
of
acute
lower
respiratory
tract
infections
(LRTI)
in
children.
However,
how
viral
load
and
genetic
variation
HBoV
may
influence
the
severity
LRTI
with
remains
unknown.
Pediatric Pulmonology,
Journal Year:
2025,
Volume and Issue:
60(1)
Published: Jan. 1, 2025
ABSTRACT
Background
The
COVID‐19
pandemic
has
significantly
altered
the
etiological
spectrum
and
epidemiological
characteristics
of
pediatric
respiratory
diseases,
a
profound
understanding
these
changes
is
crucial
for
guiding
clinical
treatment.
purpose
this
study
to
analyze
patterns
features
pathogens
in
bronchoalveolar
lavage
fluid
(BALF)
from
children
with
lower
tract
infections
(LRTIs)
after
pandemic,
aim
providing
effective
therapeutic
evidence
practice.
Methods
This
enrolled
patients
diagnosed
LRTIs
who
were
treated
underwent
BALF
pathogen
detection
at
our
hospital
June
1,
2023,
2024.
Demographic
outcomes
patients,
along
results
detection,
meticulously
collected
subsequently
analyzed.
Results
A
total
682
examinations
included
study.
In
LRTIs,
winter
was
peak
season
disease
onset.
Regarding
diagnostic
categories,
lobar
pneumonia
bronchopneumonia
most
common
representing
62.5%
27.1%
cases,
respectively.
vast
majority
showed
complete
recovery
symptoms
or
imaging
findings
within
2
weeks
receiving
examination
revealed
that
five
frequently
identified
Mycoplasma
pneumoniae
(83.1%),
followed
by
Streptococcus
(21.3%),
Haemophilus
influenzae
(16.6%),
Staphylococcus
aureus
(11.7%),
Human
Respiratory
Syncytial
Virus
(11.3%).
Conclusion
complex,
necessitating
targeted
treatments
tailored
predominant
pathogens.
Chinese Medical Journal,
Journal Year:
2024,
Volume and Issue:
137(24), P. 2953 - 2978
Published: Nov. 6, 2024
Respiratory
syncytial
virus
(RSV)
is
an
enveloped,
negative-sense,
single-stranded
RNA
of
the
Orthopneumovirus
genus
Pneumoviridae
family
in
order
Mononegavirales.
RSV
can
cause
acute
upper
and
lower
respiratory
tract
infections,
sometimes
with
extrapulmonary
complications.
The
disease
burden
infection
enormous,
mainly
affecting
infants
older
adults
aged
75
years
or
above.
Currently,
treatment
options
for
are
largely
supportive.
Prevention
strategies
remain
a
critical
focus,
efforts
centered
on
vaccine
development
use
prophylactic
monoclonal
antibodies.
To
date,
three
vaccines
have
been
approved
active
immunization
among
individuals
60
For
children
who
not
eligible
these
vaccines,
passive
recommended.
A
newly
antibody,
Nirsevimab,
which
offers
enhanced
neutralizing
activity
extended
half-life,
provides
exceptional
protection
high-risk
young
children.
This
review
comprehensive
detailed
exploration
RSV's
virology,
immunology,
pathogenesis,
epidemiology,
clinical
manifestations,
options,
prevention
strategies.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Sept. 23, 2024
Respiratory
syncytial
virus
(RSV)
is
a
prominent
etiological
agent
of
lower
respiratory
tract
infections
in
children,
responsible
for
approximately
80%
cases
pediatric
bronchiolitis
and
50%
infant
pneumonia.
Despite
notable
progress
the
diagnosis
management
RSV
infection,
current
biomarkers
early-stage
detection
remain
insufficient
to
meet
clinical
needs.
Therefore,
development
more
effective
infection
(EPR)
imperative.
