Management of Respiratory Viral Infection in Children DOI Creative Commons
Maria‐Corina Serban,

Silvia Aura Costin,

Gabriela Isabela Verga

et al.

Technium BioChemMed, Journal Year: 2024, Volume and Issue: 11, P. 91 - 101

Published: Dec. 21, 2024

Respiratory viral infections are a major cause of morbidity and mortality in children, posing significant burden on healthcare systems. A proper understanding the epidemiology, diagnostic methods, management strategies is essential to improve paediatric care avoid unjustified use antibiotics, thereby contributing fight against antimicrobial resistance. Aim: This study aims provide comprehensive synthesis literature respiratory focusing role antibiotics importance preventive measures. Methodology: For this review, an initial 87,000 articles were identified from seven databases, following PRISMA protocol. After removing duplicates applying exclusion criteria, 200 reviewed, which 43 selected for final synthesis. Results: The highlights diversity agents involved, including RSV, influenza viruses, rhinoviruses. It emphasizes that effective only cases bacterial superinfections. Vaccination hygiene measures crucial prevention, while health education plays central reducing infection incidence. Conclusions: Optimal children requires multidisciplinary approach centred prevention accurate diagnosis. underscores need evidence-based protocols, as well communities. These findings solid foundation developing tailored policies contribute improving clinical practices paediatrics.

Language: Английский

Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection DOI
An Li,

Qianwen Zhai,

Keyu Tao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155761 - 155761

Published: May 21, 2024

Language: Английский

Citations

9

The Impact of COVID‐19 Pandemic on Respiratory Syncytial Virus Infection in Children DOI Creative Commons

Jose Boris Trigueros Montes,

Diego Montes,

Andrew S. Miele

et al.

Pulmonary Medicine, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Background/Objective: Respiratory syncytial virus (RSV) is a major cause of bronchiolitis in infants and young children. Bronchiolitis, an acute inflammation the lower respiratory tract, can lead to pneumonia, failure, death. We aimed compare incidence severity RSV infection children aged 0–60 months before during coronavirus disease 2019 (COVID‐19) pandemic. Methods: A retrospective chart review was conducted on patients who tested positive for between May 1, 2018, 31, 2022, community hospital Queens County, New York City, United States. Comparisons were made seasons 2018–2019 2019–2020 as before, 2020–2021 2021–2022 COVID‐19 Severity assessed using Bronchiolitis Score (BSS). Data analyzed R software, p value < 0.05 considered statistically significant. Results: The peaked from mid‐October February, whereas first season pandemic (2020–2021) truncated with very low infection, September January, highest (37%) frequency at any given point. Patients older ( H [2, 196.6] = 12.5, 0.001, 95% C I [5.4, 25.6]) had milder illness 187.5] 7.5, 0.01, [2.1, 19.2]). Conclusions: observed rate hospitalization second began earlier, lasted longer, frequency. Older illnesses affected most this season. epidemiology burden impacted by could have significant ramifications its prevention control strategies.

Language: Английский

Citations

3

Severe Acute Lower Respiratory Tract Infection Following Human Bocavirus Mono-Infection in the Young in Southeast China DOI

Luo-Na Lin,

Xin Cong, Yujia Li

et al.

Published: Jan. 1, 2025

Background: Human bocavirus (HBoV) has emerged as a pathogenic cause of acute lower respiratory tract infections (LRTI) in children. However, how viral load and genetic variation HBoV may influence the severity LRTI with remains unknown.

Language: Английский

Citations

0

Structure switching aptamer enhance sensitivity and specificity of photonic crystal-based sensors for RSV-G protein detection DOI

Iqra Kalsoom,

Kiran Shehzadi,

Muhammad Irfan

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 273, P. 117091 - 117091

Published: Jan. 9, 2025

Language: Английский

Citations

0

Epidemiological Characteristics of Pathogens in Bronchoalveolar Lavage Fluid in Children With Lower Respiratory Tract Infections: A Retrospective Analysis DOI Open Access
Lei Zhang, Yiheng Wang, Yu Zheng

et al.

Pediatric Pulmonology, Journal Year: 2025, Volume and Issue: 60(1)

Published: Jan. 1, 2025

ABSTRACT Background The COVID‐19 pandemic has significantly altered the etiological spectrum and epidemiological characteristics of pediatric respiratory diseases, a profound understanding these changes is crucial for guiding clinical treatment. purpose this study to analyze patterns features pathogens in bronchoalveolar lavage fluid (BALF) from children with lower tract infections (LRTIs) after pandemic, aim providing effective therapeutic evidence practice. Methods This enrolled patients diagnosed LRTIs who were treated underwent BALF pathogen detection at our hospital June 1, 2023, 2024. Demographic outcomes patients, along results detection, meticulously collected subsequently analyzed. Results A total 682 examinations included study. In LRTIs, winter was peak season disease onset. Regarding diagnostic categories, lobar pneumonia bronchopneumonia most common representing 62.5% 27.1% cases, respectively. vast majority showed complete recovery symptoms or imaging findings within 2 weeks receiving examination revealed that five frequently identified Mycoplasma pneumoniae (83.1%), followed by Streptococcus (21.3%), Haemophilus influenzae (16.6%), Staphylococcus aureus (11.7%), Human Respiratory Syncytial Virus (11.3%). Conclusion complex, necessitating targeted treatments tailored predominant pathogens.

Language: Английский

Citations

0

Impact of the COVID-19 pandemic on the respiratory syncytial virus infections in children admitted with community acquired pneumonia: a retrospective study at a tertiary hospital of Northeast China DOI
Xiaoyi Xu, Lingling Wu, Yi Liu

et al.

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0

Algal Bioactives: Unlocking Future Frontiers in Respiratory Therapeutics DOI Creative Commons

Prisca Deviani Pakan,

Alexander Chi Wang Siu,

Hannah Lee

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106778 - 106778

Published: May 1, 2025

Language: Английский

Citations

0

Epidemiological and clinical characteristics of bacterial co-detection in respiratory syncytial virus-positive children in Wenzhou, China, 2021 to 2023 DOI Creative Commons
Xing Qu,

Xuanlin Ye,

Jian Yu

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 14, 2025

Language: Английский

Citations

0

Landscape of respiratory syncytial virus DOI Creative Commons
Yuping Duan,

Zimeng Liu,

Na Zang

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: 137(24), P. 2953 - 2978

Published: Nov. 6, 2024

Respiratory syncytial virus (RSV) is an enveloped, negative-sense, single-stranded RNA of the Orthopneumovirus genus Pneumoviridae family in order Mononegavirales. RSV can cause acute upper and lower respiratory tract infections, sometimes with extrapulmonary complications. The disease burden infection enormous, mainly affecting infants older adults aged 75 years or above. Currently, treatment options for are largely supportive. Prevention strategies remain a critical focus, efforts centered on vaccine development use prophylactic monoclonal antibodies. To date, three vaccines have been approved active immunization among individuals 60 For children who not eligible these vaccines, passive recommended. A newly antibody, Nirsevimab, which offers enhanced neutralizing activity extended half-life, provides exceptional protection high-risk young children. This review comprehensive detailed exploration RSV's virology, immunology, pathogenesis, epidemiology, clinical manifestations, options, prevention strategies.

Language: Английский

Citations

2

Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection DOI Creative Commons

Bochun Cao,

Menglu Li, Xiaoping Li

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 23, 2024

Respiratory syncytial virus (RSV) is a prominent etiological agent of lower respiratory tract infections in children, responsible for approximately 80% cases pediatric bronchiolitis and 50% infant pneumonia. Despite notable progress the diagnosis management RSV infection, current biomarkers early-stage detection remain insufficient to meet clinical needs. Therefore, development more effective infection (EPR) imperative.

Language: Английский

Citations

1