Reproductive Toxicity of Zearalenone and Its Molecular Mechanisms: A Review

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 505 - 505

Published: Jan. 23, 2025

Zearalenone (ZEA) is one of the common mycotoxins in feeds. ZEA and its metabolites have estrogen-like activity can competitively bind to estrogen receptors, causing reproductive dysfunction damage organs. The toxicity mechanism mainly inhibits antioxidant pathway enzyme activity, induces cell cycle arrest DNA damage, blocks process cellular autophagy produce toxic effects. In animal husbandry practice, when animals ingest ZEA-contaminated feed, it likely lead abortion females, abnormal sperm viability males with inflammatory reactions various organs, cancerous changes organs humans they contaminated products. this paper, we reviewed detail how oxidative by inducing generation reactive oxygen species (ROS) regulating expression genes related pathways, germ apoptosis through mitochondrial death receptor activates order induce autophagy. addition, molecular detoxification also explored aiming provide a new direction theoretical basis for development methods better reduce global pollution harm caused ZEA.

Language: Английский

Debaryomyces hansenii alone and in combination with plant extracts reduce ochratoxin A in dry-cured “chorizo”

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116512 - 116512

Published: April 1, 2025

Language: Английский