Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review DOI Open Access

Qiongxia Lv,

Wenjing Xu, Fan Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11003 - 11003

Published: Oct. 13, 2024

Zearalenone (ZEA) is a mycotoxin produced by Fusarium spp. fungi and widely found in moldy corn, wheat, barley, other grains. ZEA distributed to the whole body via blood circulation after metabolic transformation animals. Through oxidative stress, immunosuppression, apoptosis, autophagy, mitochondrial dysfunction, leads hepatitis, neurodegenerative diseases, cancer, abortion, stillbirth female animals, decreased sperm motility male In recent years, due influence of climate, storage facilities, factors, problem pollution global food crops has become particularly prominent, resulting serious problems for animal husbandry feed industries, threatening human health. Resveratrol (RSV) natural product with therapeutic activities such as anti-inflammatory, antioxidant, anticancer properties. RSV can alleviate ZEA-induced toxic effects targeting signaling pathways NF-κB, Nrf2/Keap1, PI3K/AKT/mTOR attenuating damage, inflammatory response, regulating cellular autophagy. Therefore, this paper provides review protective effect against toxicity its molecular mechanism, discusses safety potential clinical applications search detoxification agents.

Language: Английский

A Comprehensive Review of Mycotoxins, Their Toxicity, and Innovative Detoxification Methods DOI Creative Commons
Ravikant Shekhar, Vinay B. Raghavendra,

P. Rachitha

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101952 - 101952

Published: Feb. 7, 2025

A comprehensive overview of food mycotoxins, their toxicity, and contemporary detoxification techniques is given in this article. Mycotoxins, which are harmful secondary metabolites generated by a variety fungi, including Fusarium, Aspergillus, Penicillium, provide serious health concerns to humans animals. These include hepatotoxicity, neurotoxicity, carcinogenicity. Mycotoxins commonly found basic products, as evidenced recent studies, raising worries about public safety. The article discusses detection such enzyme-linked immunosorbent assays (ELISA), quick strip tests. Moreover, the use various control systems associated with mycotoxinis highlighted. In addition, novel strategies nanotechnology, plant extracts, omics studies were also discussed. When taken whole, analysis helps clarify pressing need for efficient management monitoring prevent mycotoxin contamination chain.

Language: Английский

Citations

2
Postharvest management of mycotoxins in supply chains of agricultural produces DOI
Sofia Agriopoulou, Slim Smaoui, Theodoros Varzakas

et al.

CABI Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Mycotoxins are secondary metabolites produced by filamentous fungi responsible for the contamination of food and feedstuffs. The presence mycotoxins causes relevant economic losses negative effects on both human animal health. Strategies related to good agricultural processing practices offer satisfactory results in reduction mycotoxins. Practices such as agriculture practices, manufacturing practice, storage application hazard analysis monitoring critical points must be implemented. need effective detoxification availability products safe from is becoming more imperative, all links supply chain course final consumers these products. In addition traditional techniques that have been used attempt detoxify mycotoxins, innovative nanotechnological biotechnological approaches emerged with increasingly promising results. main goal this review highlight impacts suggest postharvest management production marketing mycotoxin-free Traditional physical, chemical microbiological methods discussed preventing degradation feed

Language: Английский

Citations

0
Molecular docking technology drives multidimensional applications of microbial natural products DOI

Chan Zhang,

Qingjie Sun,

Arzugul Ablimit

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142044 - 142044

Published: March 1, 2025

Language: Английский

Citations

0
Isolation and Characterization of Bacillus velezensis YM1 and its Mechanism for Zearalenone Degradation DOI Creative Commons

Jiangtao Feng,

DU Xiao-yan,

Yuying Zhang

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117810 - 117810

Published: April 1, 2025

Language: Английский

Citations

0
Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review DOI Open Access

Qiongxia Lv,

Wenjing Xu, Fan Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11003 - 11003

Published: Oct. 13, 2024

Zearalenone (ZEA) is a mycotoxin produced by Fusarium spp. fungi and widely found in moldy corn, wheat, barley, other grains. ZEA distributed to the whole body via blood circulation after metabolic transformation animals. Through oxidative stress, immunosuppression, apoptosis, autophagy, mitochondrial dysfunction, leads hepatitis, neurodegenerative diseases, cancer, abortion, stillbirth female animals, decreased sperm motility male In recent years, due influence of climate, storage facilities, factors, problem pollution global food crops has become particularly prominent, resulting serious problems for animal husbandry feed industries, threatening human health. Resveratrol (RSV) natural product with therapeutic activities such as anti-inflammatory, antioxidant, anticancer properties. RSV can alleviate ZEA-induced toxic effects targeting signaling pathways NF-κB, Nrf2/Keap1, PI3K/AKT/mTOR attenuating damage, inflammatory response, regulating cellular autophagy. Therefore, this paper provides review protective effect against toxicity its molecular mechanism, discusses safety potential clinical applications search detoxification agents.

Language: Английский

Citations

2